United States:
HAI pursues innovative research concerning the pathogenesis of the AIDS virus, the treatment of HIV/AIDS, and the dynamics of the epidemic. More importantly, HAI has translated this research into health care solutions for resource-poor populations in the United States, and especially in Africa and Asia. In fact, with expanded domestic efforts now covering much of the public health landscape for the epidemic in the United States, the focus of HAI is on its specific international partnerships that create strong, on-the-ground efforts with specific countries affected by the epidemic.

Tanzania:
Tanzania has been a major African site for Harvard-sponsored nutritional intervention studies, and through clinical trails the widest range of HIV subtypes discovered in any African country has been identified in Tanzania. Currently, more than 1,500 mother-infant pairs have completed intervention trials in the country. Studies are now expanding to northern Tanzania to address HIV/AIDS in rural communities and small hospitals.

Thailand:
Over the last five years, more than 2,400 mother-infant pairs have completed HIV/AIDS intervention trials sponsored by HAI in Thailand.

The Institute has provided training for a significant percentage of Thailand's academic HIV/AIDS specialists, and has established an HIV/AIDS research, training, and support network among 14 hospitals in the country. In 2000, the Thai government adopted a chemoprophylaxis regimen as the national standard that was identified by a Harvard trial.

In northern Thailand, a large, multidisciplinary AIDS Care Team of Thai experts has been created through the multi-country Enhancing Care Initiative, a five-year HAI project.

Harvard has received awards from Thailand's Mahidol University, the City of Bangkok, and the Prime Minister of Thailand for contributions related to HIV and AIDS.

South Africa, KwaZulu-Natal (KZN) Province:
Collaboration with South African university-based researchers, NGOs, and policy-makers was established via HAI's Enhancing Care Initiative, a multi-country 5-year HIV research and intervention project.

AIDS care training programs developed by KZN researchers with HAI will train 30% of all health care workers in the province in specialized HIV/AIDS care.

Enhancing Care Initiative Team members in KZN have recently developed a successful funding proposal to the Global Fund to Fight AIDS, Tuberculosis, and Malaria. The cumulative Global Fund award was US$11.4 million to the KZN Team.

Botswana:
The largest HIV/AIDS Reference Laboratory in Africa has recently been built through the sponsorship of the Botswana–HAI Partnership for Research and Education.

The first large-scale antiretroviral drug treatment program in Africa has been initiated through this partnership, with 120,000 HIV/AIDS patients to be treated within the next 3 years. 650 adults and their families are currently enrolled in a trial-based antiretroviral treatment program.

A large mother-infant breastfeeding chemoprophylaxis trail is also underway, treating 1,500 mother-infant pairs.

Botswana is planned as a major future site of HIV vaccine trials.

For more information visit bhp.org.bw.
China (China Project):
HAI’s China Project is a multi-faceted collaboration dedicated to curbing the epidemic and mitigating its impact in China.

The China Project began with joint laboratory research and vaccine development being conducted in concert with HAI of Virology, Chinese Academy of Preventive Medicine, Beijing and the Nankai University Vaccine Laboratory, Tianjin, where HAI researcher Yichen Lu serves as Director.

At program offices in Boston and Tianjin, China Project staff work to identify and move forward promising initiatives, partnering with a variety of organizations already working in China.

For more information, please contact Ellen Stiefvater at estiefva@hsph.harvard.edu.
Senegal:
The partnership between HAI and Senegal is the longest standing HIV/AIDS collaboration in Africa. The partnership led to the discovery of HIV-2, the second AIDS virus, and numerous other landmark discoveries.

HAI also has been involved with the training of many health leaders in the region, including the Senegalese Minister of Health, and the Directors of the National AIDS Program and National Reference Laboratory, as well as providing training for hundreds of other health care professionals.

The first comprehensive HIV/AIDS prevention and antiretroviral treatment program in Senegal was created through this partnership, and over 2,000 women and their children are currently enrolled in similar long-term cohort studies in the country.

UNAIDS has described this collaboration as the best example of "AIDS prevention success in sub-Saharan Africa."

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