James R. Mitchell

Associate Professor of Genetics and Complex Diseases

655 Huntington Avenue
Building 2, 1st Floor, Room 121
Boston, Massachusetts 02115
Phone: 617.432.7286

Other Affiliations

Ph.D. Program in Biological Sciences in Public Health

Research Interests

Research in my lab is focused on nutritional, genetic and molecular mechanisms of adaptive stress resistance. Our primary interest is in dietary restriction, best known for its ability to extend lifespan in organisms as diverse as roundworms, fruit flies, and yeast, but also with the proven ability to improve metabolic fitness and stress resistance. We are currently exploring how dietary restriction works, and how it may be translated in practical ways to address a wide range of clinical problems. We also study adaptive responses to genotoxic stress, including effects of DNA damage and repair on energy metabolism, in a mouse model of the premature aging disorder Cockayne syndrome. Finally, we are interested in the effects of host nutrition on immunometabolism and infection in a mouse model of malaria.


Undergraduate studies
B.A., 1993, University of Virginia

Graduate studies
Ph.D., 2000, University of California, Berkeley

Postdoctoral training
Erasmus MC University Medical Center, Rotterdam, the Netherlands

Photo: Kent Dayton/Harvard Chan School