3rd Annual John B. Little Symposium
“Genetic and Cellular Factors in Human Cancer Therapy”
October 20-21, 2000
Friday, October 20, 2000
JBL Award Lecture given by Dr. Eric J. Hall Columbia University “Radiation, The Double Edged Sword: A Cure and Cause of Cancer” Presentation of John B. Little Award in Radiation Sciences to Dr. Hall Dr. Warren W. Nichols, Merck Research Laboratories |
INTRODUCTION Dr. Joel S. Bedford Colorado State University |
SESSION I: GENETIC DIFFERENCES BETWEEN TUMOR AND NORMAL CELLS: IMPLICATIONS FOR THERAPY |
DISCUSSION LEADER: Simon N. Powell Massachusetts General Hospital |
Wafik El-Deiry University of Pennsylvania School of Medicine “Overview of Pathways and Strategies to Selectively Kill Cancer Cells: Targeting p53 and Death Receptor Pathways” |
J. Martin Brown Stanford Medical School “Apoptosis, p53 and Tumor Response to Therapy” |
Stanley Korsmeyer Dana-Farber Cancer Institute “Integrating the Cell Death Pathway” |
Peter Glazer Yale School of Medicine “Radiation Response in Mammalian Cells: DNA Repair Meets Signal Transduction” |
David Livingston Dana-Farber Cancer Institute “Functional Analysis of the BRCA1 and 2 Gene Products” |
Saturday, October 21, 2000
SESSION II: CELL TO CELL INTERACTIONS |
DISCUSSION LEADER: S. J. Adelstein Harvard Medical School |
Rakesh Jain Massachusetts General Hospital “Role of Host-Tumor Interactions in Tumor Angiogenesis and Response to Therapy” |
Joseph O’Donoghue Memorial Sloan Kettering Center “Targeted Radionuclide Therapy: Where Physics and Biology Meet” |
Judah Folkman Harvard Medical School “Angiogenesis Research: From Laboratory to Clinic” |
John B. Little Harvard School of Public Health “Intercellular Transmission of Radiation Damage Signals” |
Roger Howell New Jersey Medical School “Bystander Effects Caused by Nonuniform Distribution of Radioactivity”
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SESSION III: LONG-TERM CONSEQUENCES OF RADIATION THERAPY: SECONDARY CANCERS |
DISCUSSION LEADER: Joseph D. Brain Harvard School of Public Health |
Joseph D. Brain Harvard School of Public Health “Introduction: Non-cancer Endpoints” |
John D. Boice International Epidemiologic Institute “Treatment of Adults with Cancer” |
Steven L. Hancock Stanford Medical School “Factors Affecting Risk of Secondary Cancers and Adverse Cardiac Effects” |
Frederick P. Li Harvard School of Public Health “Genetic Susceptibility and Secondary Tumors Among Children with Cancer” |
Carolyn A. Felix University of Pennsylvania School of Medicine “Secondary Leukemias” |