4th Annual John B. Little Symposium
“Radiation Damage to DNA: Repair and Cellular Response”
October 12-13, 2001
Friday, October 12, 2001
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JBL Award Lecture given by James L. German Weill Medical College of Cornell University “Four Decades of Bloom’s Syndrome” Presentation of John B. Little Award in Radiation Sciences to Dr. German Warren W. Nichols, Merck Research Laboratories |
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SESSION I: CLUSTERED DAMAGE AND COMPLEX INTERACTIONS |
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DISCUSSION LEADER: S. James Adelstein Harvard Medical School |
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John Ward University of California, San Diego “The variety of radiation-induced DNA strand breaks” |
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Paul W. Doetsch Emory University School of Medicine “Transcriptional mutagenesis in prokaryotic and eukaryotic systems” |
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Sankar Mitra University of Texas Medical Branch, Galveston “Effects of oxidative stress on the dynamics of early repair enzymes for oxidative DNA damage in human cells” |
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Carol Prives Columbia University “The expanding roles of p53 and its relatives” |
Saturday, October 13, 2001
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SESSION II: MECHANISMS OF DOUBLE STRAND BREAK REPAIR |
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DISCUSSION LEADER: Kathryn D. Held Massachusetts General Hospital |
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Maria Jasin Memorial Sloan Kettering Cancer Center “Genomic integrity and double-strand break repair in mammalian cells” |
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Alan D. D’Andrea Dana-Farber Cancer Institute “Interactions of the Fanconi anemia proteins and Brca1 in a common pathway” |
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Fred Alt Harvard Medical School “Interplay between non-homologous end joining and cell cycle checkpoint pathways in normal development and tumor suppression” |
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Tom K. Hei Columbia University “Radiation-induced genotoxic damage in mammalian cells: From cytoplasm to nucleus and the bystander phenomenon” |
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SESSION III: CELL RESPONSES TO RADIATION DAMAGE |
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DISCUSSION LEADER: Bruce Demple Harvard School of Public Health |
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James E. Haber Brandeis University “Adaptation and recovery following a single chromosome break” |
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George Iliakis Thomas Jefferson University “Double-strand break repair and cellular responses” |
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John Petrini University of Wisconsin “The Mre11 complex: linking DNA recombination and cell cycle regulation to the suppression of malignancy” |
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Carrolee Barlow Salk Institute “Using ATM-deficient mice to study the role of ATM in damage response pathways” |
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William F. Morgan University of Maryland “Radiation-induced genomic instability and bystander effects: A little goes a long way” |