5th Annual John B. Little Symposium
“Cell Signaling in Radiobiology and Carcinogenesis”
November 1-2, 2002
John B. Little, MD, Chair, Department of Cancer Cell Biology and James Stevens Simmons Professor, Emeritus with Philip C. Hanawalt, Dr. Morris Herzstein Professor in Biology and Professor of Dermatology
Friday, November 1, 2002
| WELCOME AND INTRODUCTIONSDr. John B. Little Harvard School of Public Health Dr. Bruce Demple Harvard School of Public Health |
| John B. Little Award Lecture given by Dr. Philip HanawaltStanford University“Mechanisms and Consequences of Transcription Coupled DNA Repair” |
| SESSION I: CELL SURVIVAL AND TRANSFORMATION |
| DISCUSSION LEADER: Dr. Bruce DempleHarvard School of Public Health |
| Dr. Robert WeinbergWhitehead Institute for Biomedical Research“Transformation of Normal Human Cells into Cancer Cells” |
| Dr. Jean WangUniversity of California, San Diego“DNA Damage and Cell Fate Determination“ |
| Dr. Tyler JacksMIT Center for Cancer Research“Modeling Cancer in the Mouse“ |
| Dr. Michael GreenbergChildren’s Hospital of Boston“Signal Transduction Pathways that Regulate Cell Survival and Oncogenesis” |
Saturday, November 2, 2002
| SESSION II: DNA REPAIR AND RADIATION SIGNALING |
| DISCUSSION LEADER: Jay S. LoefflerMassachusetts General Hospital |
| Dr. David LivingstonDana-Farber Cancer Institute“Functional Analysis of the BRCA1 Gene Product“ |
| Dr. Martin LavinQueensland Institute of Medical Research“Ataxia Telangiectasia: A Paradigm for Radiosensitivity and Cancer Susceptibility” |
| Dr. Eric WrightUniversity of Dundee“Radiation-induced Signaling and Cellular Interactions In Vivo” |
| Dr. Zhi-Min YuanHarvard School of Public Health“Contribution of MDMX to DNA Damage-induced p53 Activation” |
| SESSION III: REMODELING, FROM GENES TO CELLS TO ANIMALS |
| DISCUSSION LEADER: Dr. Karl T. KelseyHarvard School of Public Health |
| Dr. Joan BruggeHarvard Medical School“Morphogenesis and Oncogenesis in Mammary Epithelial Cells” |
| Dr. Peter JonesUniversity of Southern California, Keck School of Medicine“Remodeling of Chromatin and DNA Methylation during Human Carcinogenesis” |
| Dr. Richard KolesnickMemorial Sloan-Kettering Cancer Center“Role of Membrane Rafts in the Radiation Response” |
| Dr. Mary Ann StevensonBeth Israel Deaconess Medical Center“The Role of the pkr Gene in the Stabilization of Stress-inducible mRNA” |