JBL V: Nov. 2002

5th Annual John B. Little Symposium

“Cell Signaling in Radiobiology and Carcinogenesis”

November 1-2, 2002

 

Friday, November 1, 2002

WELCOME AND INTRODUCTIONS

Dr. John B. Little

Harvard School of Public Health

Dr. Bruce Demple

Harvard School of Public Health

John B. Little Award Lecture given by Dr. Philip Hanawalt

Stanford University

Mechanisms and Consequences of Transcription Coupled DNA Repair”

 

SESSION I: CELL SURVIVAL AND TRANSFORMATION

DISCUSSION LEADER: Dr. Bruce Demple

Harvard School of Public Health 

Dr. Robert Weinberg

Whitehead Institute for Biomedical Research

“Transformation of Normal Human Cells into Cancer Cells”

Dr. Jean Wang

University of California, San Diego

DNA Damage and Cell Fate Determination

Dr. Tyler Jacks

MIT Center for Cancer Research

Modeling Cancer in the Mouse

Dr. Michael Greenberg

Children’s Hospital of Boston

“Signal Transduction Pathways that Regulate Cell Survival and Oncogenesis”

Saturday, November 2, 2002

SESSION II: DNA REPAIR AND RADIATION SIGNALING

DISCUSSION LEADER: Jay S. Loeffler

Massachusetts General Hospital 

Dr. David Livingston

Dana-Farber Cancer Institute

“Functional Analysis of the BRCA1 Gene Product

Dr. Martin Lavin

Queensland Institute of Medical Research

“Ataxia Telangiectasia: A Paradigm for Radiosensitivity and Cancer Susceptibility”

Dr. Eric Wright

University of Dundee

“Radiation-induced Signaling and Cellular Interactions In Vivo”

Dr. Zhi-Min Yuan

Harvard School of Public Health

“Contribution of MDMX to DNA Damage-induced p53 Activation”

 

SESSION III: REMODELING, FROM GENES TO CELLS TO ANIMALS

DISCUSSION LEADER: Dr. Karl T. Kelsey

Harvard School of Public Health

Dr. Joan Brugge

Harvard Medical School

“Morphogenesis and Oncogenesis in Mammary Epithelial Cells”

Dr. Peter Jones

University of Southern California, Keck School of Medicine

“Remodeling of Chromatin and DNA Methylation during Human Carcinogenesis”

Dr. Richard Kolesnick

Memorial Sloan-Kettering Cancer Center

“Role of Membrane Rafts in the Radiation Response”

Dr. Mary Ann Stevenson

Beth Israel Deaconess Medical Center

“The Role of the pkr Gene in the Stabilization of Stress-inducible mRNA”