JBL VII: Nov. 2004

7th Annual JBL Symposium

“Genetic Stability through Quality Control in Cellular Process”

November 5-6, 2004

 

Friday, November 5, 2004

WELCOME AND INTRODUCTIONS

Dr. Bruce Demple

Harvard School of Public Health

SESSION I: SIGNALING

DISCUSSION LEADER: Dr. William A. Toscano

University of Minnesota School of Public Health

Dr. James A. DeCaprio

Dana-Farber Cancer Institute, Harvard Medical School

“The ATR Kinase and the DNA Damage Response”

Dr. Michael Yaffe

Massachusetts Institute of Technology

“Phospho-Serine/Threonine-Binding Domains are Molecular Integrators of Cell Cycle Kinases and DNA Damage Responses”

Dr. Mary Ellen Perry

National Institutes of Health, National Cancer Institute

“Regulation of p53 by Mdm2”

Dr. Mats Ljungman

University of Michigan Comprehensive Cancer Center

“Role of Transcription in the Activation of DNA Damage Signaling”

Dr. Albert J. Fornace, Jr.

National Institutes of Health, National Cancer Institute

“Global Analysis of Molecular Responses to Stress with “-omic” Approaches: the Search for Agent-Specific Signatures for Radiation and other Genotoxic Agents”

Saturday, November 6, 2004

SESSION II: CANCER

DISCUSSION LEADER: Dr. Amy Kronenberg

Lawrence Berkeley National Laboratory


Dr. Gerard I. Evan

University of California San Francisco

“The Role of Ontogenesis and Tumor Suppressors in Tumor Maintenance”

Dr. Zhi-Min Yuan

Harvard School of Public Health

“Oncogenic Effects of Low-Dose Ionizing Radiation-induced Premature Senescence in Stromal Fibroblasts; a Three Dimension Co-Culture Study”

Dr. Yusaku Nakabeppu

Kyushu University, Japan 

“Defenses against Oxidative Damage in Nucleic Acids and the Suppression of Carcinogenesis and Neurodegeneration”

Dr. Aziz Sancar

University of North Carolina at Chapel Hill School of Medicine

“Circadian Cycle, Cell Cycle Checkpoints and Cancer”

 

SESSION III: REPAIR

DISCUSSION LEADER: Dr. John B. Little

Harvard School of Public Health 

Dr. Patrick Sung

Yale University 

“Mechanism of the Rad51 and Dmc1 Recombinases”

Dr. Roger Woodgate

National Institutes of Health, National Institute of Child Health and Human Development

“Y-family DNA Polymerases and their Role in Maintaining Genomic Integrity”

Dr. Nancy Maizels

University of Washington 

“Mutagenic Pathways of Repair in the Immune Response”

Dr. Bruce Demple

Harvard School of Public Health

“Life and Death: Ape1 Protein and Endogenous DNA Damage”