JBL XIV – Oct. 2011

14th Annual JBL Symposium

“Stress Responses in Radiobiology, DNA Repair and Aging”

October 28-29, 2011

Kresge Auditorium G1

 

Friday, October 28, 2011

1:00pm-1:15 pm  

WELCOME

Gökhan S. Hotamisligil, M.D., Ph.D.

Chair and J.S. Simmons Professor of Genetics and Metabolism

Department of Genetics and Complex Diseases, Harvard School of Public Health

   

INTRODUCTION

John B. Little, M.D.

James Stevens Simmons Professor of Radiobiology, Emeritus

Department of Genetics and Complex Diseases, Harvard School of Public Health

1:15pm–2:00pm  

Award Lecture: Alain Sarasin, Ph.D.

Research Director, Laboratory of Genetic Stability and Oncogenesis

Institut de cancérologie Gustave Roussy, University Paris-Sud, Villejuif, France

How rare DNA repair-deficient genetic diseases can help us understanding mutagenesis, carcinogenesis and aging

2:00pm–5:30pm  

SESSION I

Discussion Leader: James R. Mitchell, Ph.D.

Assistant Professor, Department of Genetics and Complex Diseases

Harvard School of Public Health

2:00pm–2:45pm  

Anne Willis, Ph.D.

Medical Research Council Toxicology Unit

Leicester, United Kingdom

Post-transcriptional control of gene-expression following DNA damage

2:45pm–3:30pm  

Paul Anderson, M.D., Ph.D.

Frank Austen Professor of Medicine

Brigham and Women’s Hospital and Harvard Medical School

How tRNAs inhibit protein synthesis during stress

3:30pm–4:00pm   BREAK
4:00pm–4:45pm  

Myriam Gorospe, Ph.D.

Senior Investigator, RNA Regulation Section

Laboratory of Molecular Biology and Immunology

National Institute on Aging, National Institutes of Health

Biomedical Research Center

Regulation of cancer-associated RNA-binding protein HuR by multiple DDR kinases

4:45pm–5:30pm  

Galit Lahav, Ph.D.

Associate Professor of Systems Biology

Harvard Medical School

Encoding Information through Protein Dynamics

5:30pm–7:00pm   RECEPTION in the Harvard School of Public Health Kresge Cafe

Saturday, October 29, 2011

8:00am–9:00am   BREAKFAST in the Harvard School of Public Health Cafeteria 

9:00am–12:30pm

 

SESSION II

Discussion Leader: Dipanjan Chowdhury, Ph.D.

Assistant Professor, Radiation Oncology Department, Dana-Farber

Cancer Institute; Assistant Professor, Department of Radiation Oncology

Harvard Medical School

9:00am–9:45am  

Andrei V. Gudkov, Ph.D., D.Sci.

Senior Vice President, Basic Science

Garman Family Chair, Cell Stress Biology

Roswell Park Cancer Institute

TLR5 agonist CBLB502 on the paths to radiation defense, supportive care and anticancer drug

9:45am–10:30am   Norman E. Sharpless, M.D.

Professor of Medicine and Genetics

Associate Cancer Center Director for Translational Research

The Lineberger Comprehensive Cancer Center
The University of North Carolina School of Medicine

Mitigation of the Toxicity of DNA Damaging Agents Through Pharmacological Quiescence

10:30am–11:00am  

BREAK

11:00am–11:45am   Vera Gorbunova, Ph.D. 

Associate Professor, University of Rochester Department of Biology

SIRT6 promotes DNA repair under stress by activating PARP1

11:45am–12:30pm  

Barry P. Sleckman, M.D., Ph.D.

Conan Professor of Pathology and Immunology

Chief, Division of Laboratory and Genomic Medicine

Washington University School of Medicine

DNA Damage Responses in Developing Lymphocytes 

12:30pm–2:00pm  

LUNCH in the Harvard School of Public Health Kresge Cafe 

2:00pm–4:30pm  

SESSION III

Discussion Leader: Alec C. Kimmelman, M.D., Ph.D.

Assistant Professor of Radiation Oncology

Dana-Farber Cancer Institute, Harvard Medical School

2:00pm–2:45pm  

Edward J. Calabrese, Ph.D.

Professor of Toxicology

Professor, Environmental Health Science

University of Massachusetts, School of Public Health and Health Sciences, Amherst

HORMESIS: Why it is Important to Biomedical Scientists and Physicians

2:45pm–3:30pm  

Zhi-Min Yuan, M.D., Ph.D.

Professor, Department of Radiation Oncology

University of Texas Health Science Center

Novel insight into the radio-adaptive response

3:30pm–4:15pm  

James Mitchell, Ph.D.

Assistant Professor, Department of Genetics & Complex Diseases

Harvard School of Public Health

Dietary Preconditioning Against Surgical Stress: Role of nutrient sensing

4:15pm–4:30pm  

GENERAL DISCUSSION AND CLOSING REMARKS