JBL XIV – Oct. 2011

14th Annual JBL Symposium

“Stress Responses in Radiobiology, DNA Repair and Aging”

October 28-29, 2011

Kresge Auditorium G1

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Friday, October 28, 2011

1:00pm-1:15 pm WELCOME Gökhan S. Hotamisligil, M.D., Ph.D.Chair and J.S. Simmons Professor of Genetics and MetabolismDepartment of Genetics and Complex Diseases, Harvard School of Public Health
INTRODUCTION John B. Little, M.D.James Stevens Simmons Professor of Radiobiology, EmeritusDepartment of Genetics and Complex Diseases, Harvard School of Public Health
1:15pm–2:00pm Award Lecture: Alain Sarasin, Ph.D.Research Director, Laboratory of Genetic Stability and OncogenesisInstitut de cancérologie Gustave Roussy, University Paris-Sud, Villejuif, FranceHow rare DNA repair-deficient genetic diseases can help us understanding mutagenesis, carcinogenesis and aging
2:00pm–5:30pm SESSION IDiscussion Leader: James R. Mitchell, Ph.D.Assistant Professor, Department of Genetics and Complex DiseasesHarvard School of Public Health
2:00pm–2:45pm Anne Willis, Ph.D.Medical Research Council Toxicology UnitLeicester, United KingdomPost-transcriptional control of gene-expression following DNA damage
2:45pm–3:30pm Paul Anderson, M.D., Ph.D.Frank Austen Professor of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolHow tRNAs inhibit protein synthesis during stress
3:30pm–4:00pm BREAK
4:00pm–4:45pm Myriam Gorospe, Ph.D.Senior Investigator, RNA Regulation SectionLaboratory of Molecular Biology and ImmunologyNational Institute on Aging, National Institutes of HealthBiomedical Research Center

Regulation of cancer-associated RNA-binding protein HuR by multiple DDR kinases

4:45pm–5:30pm Galit Lahav, Ph.D.Associate Professor of Systems BiologyHarvard Medical SchoolEncoding Information through Protein Dynamics
5:30pm–7:00pm RECEPTION in the Harvard School of Public Health Kresge Cafe

Saturday, October 29, 2011

8:00am–9:00am BREAKFAST in the Harvard School of Public Health Cafeteria 
9:00am–12:30pm SESSION IIDiscussion Leader: Dipanjan Chowdhury, Ph.D.Assistant Professor, Radiation Oncology Department, Dana-FarberCancer Institute; Assistant Professor, Department of Radiation OncologyHarvard Medical School
9:00am–9:45am Andrei V. Gudkov, Ph.D., D.Sci. Senior Vice President, Basic ScienceGarman Family Chair, Cell Stress Biology Roswell Park Cancer InstituteTLR5 agonist CBLB502 on the paths to radiation defense, supportive care and anticancer drug
9:45am–10:30am Norman E. Sharpless, M.D.Professor of Medicine and GeneticsAssociate Cancer Center Director for Translational ResearchThe Lineberger Comprehensive Cancer Center
The University of North Carolina School of MedicineMitigation of the Toxicity of DNA Damaging Agents Through Pharmacological Quiescence
10:30am–11:00am BREAK
11:00am–11:45am Vera Gorbunova, Ph.D. Associate Professor, University of Rochester Department of BiologySIRT6 promotes DNA repair under stress by activating PARP1
11:45am–12:30pm Barry P. Sleckman, M.D., Ph.D.Conan Professor of Pathology and ImmunologyChief, Division of Laboratory and Genomic MedicineWashington University School of MedicineDNA Damage Responses in Developing Lymphocytes
12:30pm–2:00pm LUNCH in the Harvard School of Public Health Kresge Cafe 
2:00pm–4:30pm SESSION IIIDiscussion Leader: Alec C. Kimmelman, M.D., Ph.D.Assistant Professor of Radiation OncologyDana-Farber Cancer Institute, Harvard Medical School
2:00pm–2:45pm Edward J. Calabrese, Ph.D.Professor of ToxicologyProfessor, Environmental Health ScienceUniversity of Massachusetts, School of Public Health and Health Sciences, AmherstHORMESIS: Why it is Important to Biomedical Scientists and Physicians
2:45pm–3:30pm Zhi-Min Yuan, M.D., Ph.D.Professor, Department of Radiation OncologyUniversity of Texas Health Science CenterNovel insight into the radio-adaptive response
3:30pm–4:15pm James Mitchell, Ph.D.Assistant Professor, Department of Genetics & Complex DiseasesHarvard School of Public HealthDietary Preconditioning Against Surgical Stress: Role of nutrient sensing
4:15pm–4:30pm GENERAL DISCUSSION AND CLOSING REMARKS