14th Annual JBL Symposium
“Stress Responses in Radiobiology, DNA Repair and Aging”
October 28-29, 2011
Kresge Auditorium G1
Friday, October 28, 2011
| 1:00pm-1:15 pm | WELCOME Gökhan S. Hotamisligil, M.D., Ph.D.Chair and J.S. Simmons Professor of Genetics and MetabolismDepartment of Molecular Metabolism, Harvard School of Public Health | |
| INTRODUCTION John B. Little, M.D.James Stevens Simmons Professor of Radiobiology, EmeritusDepartment of Molecular Metabolism, Harvard School of Public Health | ||
| 1:15pm–2:00pm | Award Lecture: Alain Sarasin, Ph.D.Research Director, Laboratory of Genetic Stability and OncogenesisInstitut de cancérologie Gustave Roussy, University Paris-Sud, Villejuif, FranceHow rare DNA repair-deficient genetic diseases can help us understanding mutagenesis, carcinogenesis and aging | |
| 2:00pm–5:30pm | SESSION IDiscussion Leader: James R. Mitchell, Ph.D.Assistant Professor, Department of Molecular MetabolismHarvard School of Public Health | |
| 2:00pm–2:45pm | Anne Willis, Ph.D.Medical Research Council Toxicology UnitLeicester, United KingdomPost-transcriptional control of gene-expression following DNA damage | |
| 2:45pm–3:30pm | Paul Anderson, M.D., Ph.D.Frank Austen Professor of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolHow tRNAs inhibit protein synthesis during stress | |
| 3:30pm–4:00pm | BREAK | |
| 4:00pm–4:45pm | Myriam Gorospe, Ph.D.Senior Investigator, RNA Regulation SectionLaboratory of Molecular Biology and ImmunologyNational Institute on Aging, National Institutes of HealthBiomedical Research Center
Regulation of cancer-associated RNA-binding protein HuR by multiple DDR kinases |
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| 4:45pm–5:30pm | Galit Lahav, Ph.D.Associate Professor of Systems BiologyHarvard Medical SchoolEncoding Information through Protein Dynamics | |
| 5:30pm–7:00pm | RECEPTION in the Harvard School of Public Health Kresge Cafe |
Saturday, October 29, 2011
| 8:00am–9:00am | BREAKFAST in the Harvard School of Public Health Cafeteria | |
| 9:00am–12:30pm | SESSION IIDiscussion Leader: Dipanjan Chowdhury, Ph.D.Assistant Professor, Radiation Oncology Department, Dana-FarberCancer Institute; Assistant Professor, Department of Radiation OncologyHarvard Medical School | |
| 9:00am–9:45am | Andrei V. Gudkov, Ph.D., D.Sci. Senior Vice President, Basic ScienceGarman Family Chair, Cell Stress Biology Roswell Park Cancer InstituteTLR5 agonist CBLB502 on the paths to radiation defense, supportive care and anticancer drug | |
| 9:45am–10:30am | Norman E. Sharpless, M.D.Professor of Medicine and GeneticsAssociate Cancer Center Director for Translational ResearchThe Lineberger Comprehensive Cancer Center The University of North Carolina School of MedicineMitigation of the Toxicity of DNA Damaging Agents Through Pharmacological Quiescence |
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| 10:30am–11:00am | BREAK | |
| 11:00am–11:45am | Vera Gorbunova, Ph.D. Associate Professor, University of Rochester Department of BiologySIRT6 promotes DNA repair under stress by activating PARP1 | |
| 11:45am–12:30pm | Barry P. Sleckman, M.D., Ph.D.Conan Professor of Pathology and ImmunologyChief, Division of Laboratory and Genomic MedicineWashington University School of MedicineDNA Damage Responses in Developing Lymphocytes | |
| 12:30pm–2:00pm | LUNCH in the Harvard School of Public Health Kresge Cafe | |
| 2:00pm–4:30pm | SESSION IIIDiscussion Leader: Alec C. Kimmelman, M.D., Ph.D.Assistant Professor of Radiation OncologyDana-Farber Cancer Institute, Harvard Medical School | |
| 2:00pm–2:45pm | Edward J. Calabrese, Ph.D.Professor of ToxicologyProfessor, Environmental Health ScienceUniversity of Massachusetts, School of Public Health and Health Sciences, AmherstHORMESIS: Why it is Important to Biomedical Scientists and Physicians | |
| 2:45pm–3:30pm | Zhi-Min Yuan, M.D., Ph.D.Professor, Department of Radiation OncologyUniversity of Texas Health Science CenterNovel insight into the radio-adaptive response | |
| 3:30pm–4:15pm | James Mitchell, Ph.D.Assistant Professor, Department of Genetics & Complex DiseasesHarvard School of Public HealthDietary Preconditioning Against Surgical Stress: Role of nutrient sensing | |
| 4:15pm–4:30pm | GENERAL DISCUSSION AND CLOSING REMARKS |