JBL XV: Oct 2012

15th Annual JBL Symposium

October 26-27, 2012

Friday, October 26, 2012

WELCOME AND INTRODUCTIONS

Welcome, Gökhan Hotamisligil, M.D., Ph.D.

Introduction, John B. Little. M.D.

Opening Remarks, Dean Julio Frenk

SESSION I: DISCUSSION LEADER: James R. Mitchell, Ph.D.
Michael Yaffe, M.D., Ph.D.

David H. Koch Professor of Biology and Biological Engineering, MIT

Alan D. D’Andrea, M.D. 

Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology, Department of Radiation Oncology, Harvard Medical School; Scientific Director, Molecular Diagnostics Laboratory, Dana-Farber Cancer Institute

“Targeting the Fanconi Anemia/BRCA Pathway in Cancer Therapy”

Martin Brown, Ph.D.

Professor, Radiation Oncology – Radiation and Cancer Biology, Stanford University

“Circulating normal cells affect tumor radiosensitivity”

Hilary A. Coller, Ph.D.

Assistant Professor of Molecular Biology, Princeton University

“Sleeper Cells: The Secret Life of Quiescent Fibroblasts”

Tak W. Mak, Ph.D.

Director, Advanced Medical Discovery Institute; Director, The Campbell Family Institute for Breast Cancer Research; Senior Scientist, Division of Stem Cell and Developmental Biology; Advanced Medical Discovery Institute/Ontario Cancer Institute

“Metabolic Adaptation in Cancer Cells”

Saturday, October 27, 2012

SESSION II: 
DISCUSSION LEADER: Ralph Scully, Ph.D.

Anita Hjelmeland, Ph.D.

Assistant Professor of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University

“Understanding and Targeting Microenvironmental Influences on the Glioma Stem Cell Phenotype”

William Matsui, M.D.

Associate Professor of Oncology, Johns Hopkins University School of Medicine; The Sidney Kimmel Comprehensive Cancer

“Translating the cancer stem cell hypothesis from the lab to the clinic”

Brendan Manning, Ph.D.

Associate Professor of Genetics and Complex Diseases, Department of Genetics and Complex Diseases, Harvard School of Public Health

“Linking oncogenic signaling to anabolic metabolism through mTOR”

M. Celeste Simon, Ph.D.

Professor of Cell and Developmental Biology, University of Pennsylvania, Howard Hughes Medical Institute, The Abramson Family Cancer Research Institute

“Hypoxia, Metabolism, and Tumor Progression”

 SESSION III: 
DISCUSSION LEADER: Zhi-Min Yuan, M.D., Ph.D.
Jiri Lukas, M.D.  

Head of Research, Chromosome Biology Unit, Danish Cancer Society Research Centre; Centre for Genotoxic Stress Research

“Reprogramming the epigenome by DNA damage”

Ruslan Medzhitov, Ph.D.       

David W. Wallace Professor of Immunobiology, Yale School of Medicine; Investigator, Howard Hughes Medical Institute

“Accessory functions of macrophages in tumor development”

Craig Thompson, M.D.     

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center

General Discussion and Closing Remarks