Professor in the Department of Environmental Health
Professor of Pathology, HMS
Dr. Godleski’s research focuses upon the pulmonary and systemic responses to inhaled ambient air particles. His studies use cardiac and pulmonary mechanical measurements as well as cell and molecular biological approaches with inhalation exposure of experimental animal models to concentrated ambient air particles or ambient source particles. The overall hypothesis being tested in his laboratory is: Ambient urban air particles are complex mixtures with intrinsic toxicity; particulate exposure results in stimulation of lung receptors, release of reactive oxygen species, and induction of pro-inflammatory mediators that lead to local and systemic effects especially on the cardiovascular system, which ultimately account for epidemiologic associations between adverse health effects and particulate air pollution. Other work in Dr. Godleski’s laboratory uses analytical electron microscopy to quantify and identify environmental, therapeutic, diagnostic, and personal use product materials in human tissues.
M.D., 1969, University of Pittsburgh