Select Publications

Little, J.B.  1968.  Delayed initiation of DNA synthesis in irradiated human diploid cells. Nature 218:1064-5.  PMID: 5656624

Little, J.B.  1969.  Repair of sub-lethal and potentially lethal radiation damage in plateau phase cultures of human cells.  Nature 224: 804-806.  PMID: 5361657

Williams, J.R., Little, J.B., Shipley, W.U.  1974.  Association of mammalian cell death with a specific endonucleolytic degradation of DNA.  Nature 252:754-55.  PMID: 4474604

Weichselbaum, R.R., Nove, J., Little, J.B.  1978.  Deficient recovery from potentially lethal radiation damage in Ataxia telangiectasia and Xeroderma pigmentosum.  Nature 271;261-2.  PMID: 622166

Kennedy, A.R., Fox, M., Murphy, G., Little, J.B.  1980.  Relationship between x-ray exposure and malignant transformation in C3H10T1/2 cells.  Proc. Natl. Acad. Sci. USA 77:7262-6.  PMID: 6938973

Kennedy, A.R., Cairns, J.,  Little, J.B.  1984.  Timing of the steps in transformation of C3H 10T1/2 cells by x-irradiation.  Nature 307:85-6.  PMID: 6690989

Chang, W.P., Little, J.B.  1992. Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving x-irradiation: association with delayed reproductive death phenotype.  Mutation Res. 270: 191-199.  PMID: 1383736

Nagasawa, H., Little, J.B.  1992.  Induction of sister chromatid exchanges by extremely low doses of alpha particles.  Cancer Res. 52:6394-6. PMID: 1423287

Li, C-Y, Yandell, D.W., Little, J.B. 1994. Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus. Molec. Cell Biol. 14:4373-4379.  PMID: 8205536

Little, J.B., H. Nagasawa, T. Pfenning and H.Vetrovs.  1997. Radiation-induced genomic instability:  Delayed mutagenic and cytogenetic effects of x-rays and alpha particles.  Radiat. Res., 148: 299-307.  PMID:  9339945

Azzam, E.I., de Toledo, S.M., Little, J.B.  2001. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells.  Proc. Natl. Acad. Sci. USA 98: 473-478.  PMID: 11149936

Nagasawa, H., A. Cremesti, R. Kolesnick, Z. Fuks, Little, J.B.  2002.  Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res. 62: 2531-2534.

Azzam, E.I., S.M. de Toledo, D.R. Spitz, Little, J.B.  2002.  Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res. 62:5436-5443.

Little, J.B., H. Nagasawa, G.C. Li, Chen, D.J.  2003.  Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiat. Res. 159:262-267.

Azzam, E.I., S.M. de Toledo, Little, J.B.  2004. Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res. 63:7128-7135.

Nagasawa, H., Y. Peng, Y.-C. Lio, C.J. Chen, J. Bedford, Little, J.B.  2005. Role of homologous recombination in the alpha particle bystander effect for sister chromatid exchanges and chromosomal aberrations. Radiat. Res. 164:141-147.

Chuang, E.Y., Chen, X, Tsai, M-H, Yan, H., Li, C-Y, Mitchell, J.B., Nagasawa, H., Wilson, P.F., Peng, Y., Fitzek, M.M., Bedford, J.S.,  Little, J.B.  2006. Abnormal gene expression profiles in unaffected parents of patients with hereditary type retinoblastoma. Cancer Res. 66:3428-3433. PMID: 16585164

Nagasawa, H., Wilson, P.F., Chen, D.J., Thompson, L.H., Bedford, J.S., Little, J.B.  2008. Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination.  DNA Repair 7: 513-522. PMID: 18182331