Adjunct Professor of Environmental Health
Respiratory infections are an enormous public health burden. To combat infections, neutrophils travel from the pulmonary capillaries into the alveolar air spaces, where they phagocytize and kill bacteria. Proper regulation is essential; too many neutrophils or excessive neutrophil activation promotes inflammatory lung disease, whereas too few neutrophils or inadequate activation of neutrophils promotes infectious lung disease. The processes of neutrophil emigration and activation are regulated by the expression of multiple genes, including cytokines, chemokines, and adhesion molecules. Major focuses of our current work are the roles played by NF-kappaB and STAT3 transcription factors in dictating the expression of innate immunity genes in the lungs, in directing neutrophil emigration and activation, and in balancing the protective and destructive effects of pulmonary inflammatory responses.
Sc.D., 1994, Harvard Universit