Publications

Peer reviewed publications (# advisee, * corresponding author

2014

Zhang Y, Yi P, Chen W, Ming J, Zhu B, Li Z, Shen N, Shi W, Ke J, Zhao Q, Lu X, Xun X, Liu L, Song R, Guo H, Zhong R, Liang L, Huang T, Miao X. (2014) Association between polymorphisms within the susceptibility region 8q24 and breast cancer in a Chinese population. Tumour Biol. 2014 Jan 11.

Ma B#, Wilker EH, Willis-Owen SA, Byun HM, Wong KC, Motta V, Baccarelli AA, Schwartz J, Cookson WO, Khabbaz K, Mittleman MA, Moffatt MF, Liang L*. (2014) Predicting DNA methylation level across human tissues. Nucleic Acids Research. 2014 Jan 20. PMID: 24445802

2013

van der Valk RJ, Duijts L, Timpson NJ, Salam MT, Standl M, Curtin JA, Genuneit J, Kerhof M, Kreiner-Møller E, Cáceres A, Gref A, Liang L, Taal HR, Bouzigon E, Demenais F, Nadif R, Ober C, Thompson EE, Estrada K, Hofman A, Uitterlinden AG, van Duijn C, Rivadeneira F, Li X, Eckel SP, Berhane K, Gauderman WJ, Granell R, Evans DM, St Pourcain B, McArdle W, Kemp JP, Smith GD, Tiesler CM, Flexeder C, Simpson A, Murray CS, Fuchs O, Postma DS, Bønnelykke K, Torrent M, Andersson M, Sleiman P, Hakonarson H, Cookson WO, Moffatt MF, Paternoster L, Melén E, Sunyer J, Bisgaard H, Koppelman GH, Ege M, Custovic A, Heinrich J, Gilliland FD, Henderson AJ, Jaddoe VW, de Jongste JC; for the EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium. (2013) Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2013 Dec 5. pii: S0091-6749(13)01556-X. doi: 10.1016/j.jaci.2013.08.053.

Walter S, Glymour MM, Koenen K, Liang L, Tchetgen Tchetgen EJ, Cornelis M, Chang SC, Rimm E, Kawachi I, Kubzansky LD. (2013) Performance of polygenic scores for predicting phobic anxiety. PLoS One. 2013 Nov 20;8(11):e80326. doi: 10.1371/journal.pone.0080326.

Chang SC, Glymour MM, Rewak M, Cornelis MC, Walter S, Koenen KC, Kawachi I, Liang L, Tchetgen Tchetgen EJ, Kubzansky LD. (2013) Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts. Psychoneuroendocrinology. 2014 Jan;39:257-68. doi: 10.1016/j.psyneuen.2013.09.024.

Evans DM, Brion MJ, Paternoster L, Kemp JP, McMahon G, Munafò M, Whitfield JB, Medland SE, Montgomery GW; GIANT Consortium; CRP Consortium; TAG Consortium, Timpson NJ, St Pourcain B, Lawlor DA, Martin NG, Dehghan A, Hirschhorn J, Davey Smith G. (2013) Mining the human phenome using allelic scores that index biological intermediates. PLoS Genet. 2013 Oct;9(10):e1003919. doi: 10.1371/journal.pgen.1003919.

Workalemahu T, Enquobahrie DA, Moore A, Sanchez SE, Ananth CV, Pacora PN, Liang L, Salazar M, Williams MA. (2013) Genome-wide and candidate gene association studies of placental abruption. Int J Mol Epidemiol Genet. 2013 Sep 12;4(3):128-39.

Qi Q, Xu M, Wu H, Liang L, Champagne CM, Bray GA, Sacks FM, Qi L. (2013) IRS1 genotype modulates metabolic syndrome reversion in response to 2-year weight-loss diet intervention: the POUNDS LOST trial. Diabetes Care. 2013 Nov;36(11):3442-7. doi: 10.2337/dc13-0018.

Hu YJ, Berndt SI, Gustafsson S, Ganna A; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Hirschhorn J, North KE, Ingelsson E, Lin DY (2013) Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. Am J Hum Genet. doi:pii: S0002-9297(13)00280-2.10.1016/j.ajhg.2013.06.011.

Weidinger S, Willis-Owen SA, Kamatani Y, Baurecht H, Morar N, Liang L, Edser P, Street T, Rodriguez E, O’regan GM, Beattie P, Fölster-Holst R, Franke A, Novak N, Fahy CM, Winge MC, Kabesch M, Illig T, Heath S, Söderhäll C, Melén E, Pershagen G, Kere J, Bradley M, Lieden A, Nordenskjold M, Harper JI, Irwin McLean WH, Brown SJ, Cookson WO, Mark Lathrop G, Irvine AD, Moffatt MF. (2013) A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Hum Mol Genet. 2013 Jul 25.

Li L, Kabesch M, Bouzigon E, Demenais F, Farrall M, Moffatt MF, Lin X, Liang L* (2013) Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma. Frontiers in Statistical Genetics and Methodology 2013 May 31;4:103. doi: 10.3389/fgene.2013.00103.
* Corresponding author

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, Vedantam S, Wood AR, Liang L, other authors, Heid IM. (2013) Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet. 2013 Jun;9(6):e1003500. doi: 10.1371/journal.pgen.1003500.

Binia A, Van Stiphout N, Liang L, Michel S, Bhavsar PK, Fan Chung K, Brightling CE, Barnes PJ, Kabesch M, Bush A, Cookson WO, Moffatt MF. (2013) A Polymorphism Affecting MYB Binding within the Promoter of the PDCD4 Gene is Associated with Severe Asthma in Children. Hum Mutat. 2013 Apr 18. doi: 10.1002/humu.22340.

Esparza-Gordillo J, Schaarschmidt H, Liang L, Cookson W, Bauerfeind A, Lee-Kirsch MA, Nemat K, Henderson J, Paternoster L, Harper JL, Mangold E, Nothen MM, Rüschendorf F, Kerscher T, Marenholz I, Matanovic A, Lau S, Keil T, Bauer CP, Kurek M, Ciechanowicz A, Macek M, Franke A, Kabesch M, Hubner N, Abecasis G, Weidinger S, Moffatt M, Lee YA. (2013) A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis. J Allergy Clin Immunol. 2013 Apr 9. pii: S0091-6749(13)00322-9.

Paul DS, Albers CA, Rendon A, Voss K, Stephens J; HaemGen Consortium, van der Harst P, Chambers JC, Soranzo N, Ouwehand WH, Deloukas P. (2013) Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Res. 2013 Jul;23(7):1130-41.

Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu YJ, Lee SH, Liang L, other authors, Ingelsson E. (2013) Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013 Apr 26;45(5):501-12.

Zhang M, Song F, Liang L, Nan H, Zhang J, Liu H, Wang LE, Wei Q, Lee JE, Amos CI, Kraft P, Qureshi AA, Han J. (2013) Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. Hum Mol Genet. 2013 Apr 24.

Li X, Liang L, Zhang M, Song F, Nan H, Wang LE, Wei Q, Lee JE, Amos CI, Qureshi AA, Han J. (2013) Obesity-related genetic variants, human pigmentation, and risk of melanoma. Hum Genet. 2013 Mar 29.

Zhao SX, Liu W, Zhan M, Song ZY, Yang SY, Xue LQ, Pan CM, Gu ZH, Liu BL, Wang HN, Liang L, Liang J, Zhang XM, Yuan GY, Li CG, Chen MD, Chen JL, Gao GQ, Song HD; China Consortium for the Genetics of Autoimmune Thyroid Disease. (2013) A refined study of FCRL genes from a genome-wide association study for Graves’ disease. PLoS One. 2013;8(3):e57758. doi: 10.1371/journal.pone.0057758.

Zhao SX, Xue LQ, Liu W, Gu ZH, Pan CM, Yang SY, Zhan M, Wang HN, Liang J, Gao GQ, Zhang XM, Yuan GY, Li CG, Du WH, Liu BL, Liu LB, Chen G, Su Q, Peng YD, Zhao JJ, Ning G, Huang W, Liang L*, Qi L, Chen SJ, Chen Z, Chen JJ, Song HD, China Consortium for the Genetics of Autoimmune Thyroid Disease. (2013) Robust evidence for five new Graves’ disease risk loci from a staged genome-wide association analysis. Hum Mol Genet 22(16):3347-62.
* Led statistical analysis

Huang J#, Chen J#, Lathrop M, Liang L*. (2013) A tool for RNA sequencing sample identity check. Bioinformatics 29(11):1463-4
* Corresponding author

Berndt SI, Skibola CF, Joseph V, Camp NJ, other authors, Liang L, other authors, Sanjose, S, Hjalgrim H, Cerhan JR, Chanock SJ, Rothman N, Slager SL. (2013) Genome-wide Association Study Identifies Multiple Loci Associated with Chronic Lymphocytic Leukemia. Nat Genet 45(8):868-76.

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, Arden N, Raitakari O, Viikari J, Lohman KK, Ferrucci L, Melhus H, Ingelsson E, Byberg L, Lind L, Lorentzon M, Salomaa V, Campbell H, Dunlop M, Mitchell BD, Herzig KH, Pouta A, Hartikainen AL; Genetic Investigation of Anthropometric Traits-GIANT Consortium, Streeten EA, Theodoratou E, Jula A, Wareham NJ, Ohlsson C, Frayling TM, Kritchevsky SB, Spector TD, Richards JB, Lehtimäki T, Ouwehand WH, Kraft P, Cooper C, März W, Power C, Loos RJ, Wang TJ, Järvelin MR, Whittaker JC, Hingorani AD, Hyppönen E. (2013) Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10(2):e1001383. doi: 10.1371/journal.pmed.1001383.

Pandey RC, Michel S, Schieck M, Binia A, Liang L, Klopp N, Franke A, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Illig T, Kabesch M. (2013) Polymorphisms in extracellular signal-regulated kinase family influence genetic susceptibility to asthma. J Allergy Clin Immunol. 2013 Apr; 131(4):1245-7.

Liang L, Morar N, Dixon AL, Lathrop GM, Abecasis GR, Moffatt MF, Cookson WO (2013) A cross-platform catalogue of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines. Genome Research 23(4):716-26

Pandey RC, Michel S, Tesse R, Binia A, Schedel M, Liang L, Klopp N, Franke A, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Illig T, Kabesch M. (2013) Genetic variation in the Toll-like receptor signaling pathway is associated with childhood asthma. J Allergy Clin Immunol. 2013 Feb;131(2):602-5. doi: 10.1016/j.jaci.2012.10.061.

Machiela MJ, Chen C, Liang L, Diver WR, Stevens VL, Tsilidis KK, Haiman CA, Chanock SJ, Hunter DJ, Kraft P; on behalf of the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. (2013) One thousand genomes imputation in the national cancer institute breast and prostate cancer cohort consortium aggressive prostate cancer genome-wide association study. Prostate. 2013 May;73(7):677-89.

2012

Wu C, Kraft P, Zhai K, Chang J, Wang Z, Li Y, Hu Z, He Z, Jia W, Abnet CC, Liang L, Hu N, Miao X, Zhou Y, Liu Z, Zhan Q, Liu Y, Qiao Y, Zhou Y, Jin G, Guo C, Lu C, Yang H, Fu J, Yu D, Freedman ND, Ding T, Tan W, Goldstein AM, Wu T, Shen H, Ke Y, ZengY, Chanock SJ, Taylor PR, Lin D. (2012) Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet Sep 9. doi: 10.1038/ng.2411.

van der Harst P, Zhang W, Leach IM, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, other authors, Liang L, other authors, Hicks AA, Penninger JM, Gieger C, Kooner JS, Ouwehand WH, Soranzo N, Chambers JC. (2012) Seventy-five genetic loci influencing the human red blood cell. Nature 2012 Dec 20;492(7429):369-75. doi: 10.1038/nature11677.

Qi Q, Menzaghi C, Smith S, Liang L, de Rekeneire N, Garcia ME, Lohman KK, Miljkovic I, Strotmeyer ES, Cummings SR, Kanaya AM, Tylavsky FA, Satterfield S, Ding J, Rimm EB, Trischitta V, Hu FB, Liu Y, Qi L. (2012) Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. Hum Mol Genet. 2012 Nov 1;21(21):4774-80. doi: 10.1093/hmg/dds300.

Meng S, Zhang M, Liang L, Han J. (2012) Current opportunities and challenges: genome-wide association studies on pigmentation and skin cancer. Pigment Cell Melanoma Res. 2012 Sep;25(5):612-7. doi: 10.1111/j.1755-148X.2012.01023.x.

Clarke L, Zheng-Bradley X, Smith R, Kulesha E, Xiao C, Toneva I, Vaughan B, Preuss D, Leinonen R, Shumway M, Sherry S, Flicek P; 1000 Genomes Project Consortium. (2012) The 1000 Genomes Project: data management and community access. Nat Methods. 2012 Apr 27;9(5):459-62.

Salm MP, Horswell SD, Hutchison CE, Speedy HE, Yang X, Liang L, Schadt EE, Cookson WO, Wierzbicki AS, Naoumova RP, Shoulders CC. (2012) The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism. Genome Res. 2012 Mar 28. 

Pasaniuc B, Rohland N, McLaren PJ, Garimella K, Zaitlen N, Li H, Gupta N, Neale B, Daly M, ARRA Autism Sequencing Collaboration, Sklar P, Sullivan PF, Bergen S, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Purcell SM, Haas DW, Liang L, Sunyaev S, Patterson N, de Bakker PIW, Reich D, Price AL (2012) Extremely low-coverage sequencing enables cost effective GWAS. Nature Genetics 20;44(6):631-5.

Qi Q, Liang L, Doria A, Hu FB, Qi L. (2012) Genetic predisposition to dyslipidemia and type 2 diabetes risk in two prospective cohorts. Diabetes. 2012 Mar; 61(3):745-52.

Edgren G, Liang L, Adami H, Chang ET. (2012) Enigmatic sex disparities in cancer incidence. European Journal of Epidemiology. 2012 Mar;27(3):187-96.

Cornelis MC, Glymour MM, Chang SC, Tchetgen EJ, Liang L, Koenen KC, Kang JH, Pasquale LR, Rimm EB, Kawachi I, Kubzansky LD (2012) Oxytocin receptor (OXTR) is not associated with optimism in the Nurses’ Health Study. Mol Psychiatry. doi: 10.1038/mp.2011.178.

Zhang M, Liang L, Morar N, Dixon AL, Lathrop GM, Ding J, Moffatt MF, Cookson WOC, Kraft P, Qureshi AA, Han J. (2012) Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Study of Basal Cell Carcinoma. Human Genetics 2012 Apr;131(4):615-23.

2011

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O’Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O’Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS. (2011) Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 2011 Oct 16;43(11):1131-8. doi: 10.1038/ng.970.

The China Consortium for the Genetics of Autoimmune Thyroid Disease, Chu X, Pan CM, Zhao SX, Liang J, Gao GQ, Zhang XM, Yuan GY, Li CG, Xue LQ, Shen M, Liu W, Xie F, Yang SY, Wang HF, Shi JY, Sun WW, Du WH, Zuo CL, Shi JX, Liu BL, Guo CC, Zhan M, Gu ZH, Zhang XN, Sun F, Wang ZQ, Song ZY, Zou CY, Sun WH, Guo T, Cao HM, Ma JH, Han B, Li P, Jiang H, Huang QH, Liang L, Liu LB, Chen G, Su Q, Peng YD, Zhao JJ, Ning G, Chen Z, Chen JL, Chen SJ, Huang W, Song HD. (2011) A genome-wide association study identifies two new risk loci for Graves’ disease. Nature Genetics. doi: 10.1038/ng.898.

Zhang M, Liang L, Xu M, Qureshi AA, Han J. (2011) Pathway analysis for genome-wide association study of Basal cell carcinoma of the skin. PLoS One. 2011;6(7):e22760.

Cornelis MC, Tchetgen Tchetgen EJ, Liang L, Qi L, Chatterjee N, Hu FB, and Kraft P (2011) Gene-environment interactions in genome-wide association studies: A comparative study of tests applied to empirical studies of type 2 diabetes. American Journal of Epidemiology (doi: 10.1093/aje/kwr368)

Mexico City Childhood Asthma Study (MCAAS), Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, Baurley JW, Eng C, Stern DA, Celedón JC, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, Li X, Myers RA, Romieu I, Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque MU, Dunston GM, Watson HR, Mantese VJ, Ezurum SC, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sienra-Monge JJ, Del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske RF Jr, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ; Children’s Health Study (CHS) and HARBORS study, Gilliland FD; Genetics of Asthma in Latino Americans (GALA) Study, the Study of Genes-Environment and Admixture in Latino Americans (GALA2) and the Study of African Americans, Asthma, Genes & Environments (SAGE), Burchard EG; Childhood Asthma Research and Education (CARE) Network, Martinez FD; Childhood Asthma Management Program (CAMP), Weiss ST; Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Williams LK; Genetic Research on Asthma in the African Diaspora (GRAAD) Study, Barnes KC, Ober C, Nicolae DL. (2011) Meta-analysis of Genome-wide Association Studies of Asthma in Ethnically Diverse North American Populations. Nature Genetics. doi: 10.1038/ng.888.

Gravel S, Henn BM, Gutenkunst RN, Indap AR, Marth GT, Clark AG, Yu F, Gibbs RA; The 1000 Genomes Project, Bustamante CD. (2011) Demographic history and rare allele sharing among human populations. Proc Natl Acad Sci USA. 108(29):11983-11988.

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O’Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS; NASH CRN; GIANT Consortium; MAGIC Investigators, Voight BF, Carr JJ, Feitosa MF, Harris TB, Fox CS, Smith AV, Kao WH, Hirschhorn JN, Borecki IB; GOLD Consortium. (2011) Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 7(3):e1001324.

Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, Hormozdiari F, Iakoucheva LM, Iqbal Z, Kang S, Kidd JM, Konkel MK, Korn J, Khurana E, Kural D, Lam HY, Leng J, Li R, Li Y, Lin CY, Luo R, Mu XJ, Nemesh J, Peckham HE, Rausch T, Scally A, Shi X, Stromberg MP, Stütz AM, Urban AE, Walker JA, Wu J, Zhang Y, Zhang ZD, Batzer MA, Ding L, Marth GT, McVean G, Sebat J, Snyder M, Wang J, Ye K, Eichler EE, Gerstein MB, Hurles ME, Lee C, McCarroll SA, Korbel JO; 1000 Genomes Project. (2011) Mapping copy number variation by population-scale genome sequencing. Nature. 470(7332):59-65.

2010

Sudmant PH, Kitzman JO, Antonacci F, Alkan C, Malig M, Tsalenko A, Sampas N, Bruhn L, Shendure J; 1000 Genomes Project, Eichler EE. (2010) Diversity of human copy number variation and multicopy genes. Science. 330(6004):641-6.

Ding J*, Gudjonsson JE*, Liang L, Stuart PE, Li Y, Chen W, Weichenthal M, Ellinghaus E, Franke A, Cookson W, Nair RP, Elder JT and Abecasis GR. (2010) Gene Expression in Skin and Lymphoblastoid Cells: Refined Statistical Method Reveals Extensive Overlap in cis-eQTL Signals. American Journal of Human Genetics 87(6):779-89
* Joint first author

Michel S, Liang L, Depner M, Klopp N, Ruether A, Kumar A, Schedel M, Vogelberg C, von Mutius E, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Gut IG, Schreiber S, Lathrop M, Illig T, Kabesch M. (2010) Unifying Candidate Gene and GWAS Approaches in Asthma. PLoS ONE 5(11): e13894. doi:10.1371/journal.pone.0013894

The 1000 Genomes Project Consortium. (2010) A map of human genome variation from population scale sequencing. Nature 467: 1061–1073

Lango AH, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang Jian, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Smith AV, Mägi R, Pastinen T, Liang L, et al. (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467: 832–838

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segrè AV, Estrada K, Liang L, et al (2010) Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index. Nature Genetics 42: 937–948

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Kaplan LM, Liang L,  et al. (2010) Meta-analysis identifies 13 novel loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics 42: 949-960

Hsu Y-H, Zillikens MC, Wilson SG, Farber CR, Demissie S, Soranzo N, Bianchi EN, Grundberg E, Liang L, Richards JB, Estrada K, Zhou Y, van Nas A, Moffatt MF, Zhai G, Hofman A, van Meurs JB, Pols HAP, Price RI, Nilsson O, Pastinen T, Cupples LA, Lusis AJ, Schadt EE, Ferrari S, Uitterlinden AG, Rivadeneira F, Spector TD, Karasik D and Kiel DP. (2010) An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits. PLoS Genet 6(6): e1000977. doi:10.1371/journal.pgen.1000977

Sanna S*, Pitzalis M*, Zoledziewska M*, Zara I, Sidore C, Murru R, Whalen MB, Busonero F, Maschio A, Costa G, Melis MC, Deidda F, Poddie F, Morelli L, Farina G, Li Y, Dei M, Lai S, Mulas A, Cuccuru G, Porcu E, Liang L, Zavattari P, Moi L, Deriu E, Urru MF, Bajorek M, Satta MA, Cocco E, Ferrigno P, Sotgiu S, Pugliatti M, Traccis S, Angius A, Melis M, Rosati G, Abecasis GR, Uda M, Marrosu MG, Schlessinger D, Cucca F. (2010) Variants within the immunoregulatory CBLB gene are associated with Multiple Sclerosis. Nature Genetics 42: 495-497.
* Joint first author

Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, Tsai YJ, Yang M, Campbell M, Foster C, Gao P, Togias A, Hansel N, Diette G, Adkinson NF, Liu M, Faruque M, Dunston G, Watson H, Bracken MB, Hoh J, Maul P, Maul T, Jedlicka AE, Murray T, Hetmanski J, Ashworth R, Ongaco C, Hetrick K, Doheney K, Pugh E, Ford J. Eng C, Burchard EG, Sleiman PMA, Hakonarson H, Forno E, Raby BA, Weiss ST, Scott AF, Kabesch M, Liang L, Abecasis GR, Moffatt MF, Cookson WOC, Ruczinski I, Beaty TH, Barnes KC. (2010) A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol. 125(2):336-346.e4.Epub 2009 Nov 11.

2009

Cookson WOC, Liang L, Abecasis GR, Moffatt MF, Lathrop M. (2009) Mapping complex disease traits with global gene expression. Nature Reviews Genetics 10, 184-194 

Guan W*, Liang L*, Boehnke M, Abecasis GR. (2009) Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies. Genet Epidemiol 33(6):508-17. DOI: 10.1002/gepi.20403
* Joint first author 

Chen W, Liang L, Abecasis GR (2009) GWAS GUI: Graphical browser for the results of whole-genome association studies with high-dimensional phenotypes. Bioinformatics 25(2), 284-285 

Liang L, Chen WM, Sham PC, Abecasis GR (2009). Variance components linkage analysis with repeated measurements. Human Heredity 67, 237-247 

2008

Weidinger S, Gieger C, Rodriguez E, Mempel M, Klopp N, Gohlke H, Baurecht H, Wagenpfeil S, Ollert M, Ring J, Behrendt H, Heinrich J, Krämer U, von Berg A, Berdel D, Bauer CP, Herbart O, Koletzko S, Fischer G, Prokisch H, Meitinger T, Depner M, von Mutius E, Liang L, Moffat M, Cookson W, Kabesch M, Wichmann HE, Illig T (2008). Genome-wide scan on total serum IgE levels identifies FCER1A as susceptibility locus. PLoS Genetics 4:e1000166, 1-9

2007

Dixon AL*, Liang L*, Moffatt MF*, Chen W, Heath S, Wong KCC, Taylor J, Gut I, Farrall M, Lathrop GM, Abecasis GR, Cookson WOC (2007). A whole-genome association study of global gene expression. Nature Genetics 39, 1202-1207
* Joint first author

Moffatt MF*, Kabesch M*, Liang L*, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SAG, Wong KCC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM, Cookson WOC (2007). Genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma. Nature 448, 470-473
* Joint first author

Liang L, Zöllner S, Abecasis GR (2007). GENOME: a rapid coalescent-based whole genome simulator. Bioinformatics 23, 1565-1567

Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, Franchimont D, Vermeire S, Dewit O, de Vos M, Dixon A, Demarche B, Gut I, Heath S, Foglio M, Liang L, Laukens D, Mni M, Zelenika D, Van Gossum A, Rutgeerts P, Belaiche J, Lathrop M, Georges M (2007). Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4. PLoS Genet 3: e58, 538-543 

2006

Li M, Atmaca-Sonmez P, Othman M, Branham KE, Khanna R, Wade MS, Li Y, Liang L, Zareparsi S, Swaroop A, Abecasis GR (2006).CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nature Genetics 38, 1049-1054

Other publications

Development and/or publication of educational materials 

Liang, L. (2012) Using genomics-based approaches to uncover genes linked to asthma. Frontiers in Research Articles SeriesNature Education/Bedford Freeman Worth (invited article, in press)