Caroline Heintz

caroline_150x200

Postdoc

caheintz [at] hsph.harvard.edu

Publications: 

Heintz C, Mair W. You are what you host: Microbiome Modulation of the Aging Process. Cell. 2014 Jan; 156 (3): 408-11.

Heintz C, Cotton RGH, Blau N. The evolution of tetrahydrobiopterin test for phenylketonuria, its mode of action, and predictive value of genotypes for pharmacological chaperone therapy: A model for other diseases. Human Mutation. 2013 Jul; 34(7): 927-36.

Heintz C, Dobrowolski SF, Andersen HS, Demirkol, M, Blau N, Andresen BS. Phenylalanine hydroxylase (PAH) exon 11 is vulnerable: Molecular pathology of mutations in PAH exon 11. Molecular Genetics and Metabolism. 2012 Aug; 106(4): 403-11.

Heintz, C, Troxler, H, Martinez A, Thöny B, Blau N. Quantification of Phenylalanine Hydroxylase Activity by Isotope-Dilution Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry. Molecular Genetics and Metabolism. 2012 Apr; 105(4): 559-65.

Dobrowolski SF1, Heintz C1, Miller T, Ellingson C, Ellingson C, Özer I, Gökçay G, Baykal T, Thöny B, Demirkol M, Blau N. Molecular Genetics and Impact of In Vitro Residual Phenylalanine Hydroxylase Activity on Tetrahydrobiopterin Responsiveness in Turkish PKU Population. Molecular Genetics and Metabolism. 2011 Feb; 102(2): 116-21. 1 Authors contributed equally.

Karačić I, Meili D, Sarnavka V, Heintz C, Thöny B, Ramadža DP, Fumić K, Mardešić D, Barić I,Blau N. Genotype-predicted Tetrahydrobiopterin (BH4)-Responsiveness and Molecular Genetics in Croatian Patients with Phenylalanine Hydroxylase (PAH) Deficiency. Molecular Genetics and Metabolism. 2009 Jul; 97(3): 165-71.

Buck I, Morceau F, Christofanon S, Heintz C, Chateauvieux S, Reuter S, Dicato M, Diederich M. Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation. Biochemical Pharmacology. 2008 Nov; 76 (10): 1229–39.

Neuenschwander M, Butz M, Heintz C, Kast P, Hilvert D. A simple selection strategy for evolving highly efficient enzymes. Nature Biotechnology.2007 Oct; 25 (10): 1145-47