Postdoc
hweir[at]hsph.harvard.edu
Area of Interest/Research Focus:
Aging and age-related diseases are associated with a progressive loss of mitochondrial function, including altered mitochondrial dynamics. My research focuses on the interplay between mitochondrial dynamics, systemic energy homeostasis and aging, with a goal of identifying specific mechanisms that are causal to aging.
Publications:
Snapshot: Neuronal regulation of aging
Weir, HJ. and Mair WB
Cell. 2016 Jul 28;166(3):784-784.e1. doi: 10.1016/j.cell.2016.07.02
Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.
Burkewitz K, Morantte I, Weir HJ, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB.
Cell. 2015 Feb 26;160(5):842-55. doi: 10.1016/j.cell.2015.02.004.
SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and Disease.
Weir HJ, Lane JD, Balthasar N.
Genes Cancer. 2013 Mar;4(3-4):118-24. doi: 10.1177/1947601913476949.
CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer’s disease.
Weir HJ, Murray TK, Kehoe PG, Love S, Verdin EM, O’Neill MJ, Lane JD, Balthasar N.
PLoS One. 2012;7(11):e48225. doi: 10.1371/journal.pone.0048225. Epub 2012 Nov 6.
Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis.
Cheng JP, Betin VM, Weir H, Shelmani GM, Moss DK, Lane JD.
Cell Death Dis. 2010 Oct 7;1:e82. doi: 10.1038/cddis.2010.59.
