An emerging central upstream regulator of the response to dietary restriction is the pro-longevity AMP-activated protein kinase (AMPK), a cellular energy sensor that is activated during energy stress. AMPK is a central node for many critical nutrient responsive pathways that have been linked to longevity (see figure). One focus of our lab is identifying the longevity-specific processes regulated by AMPK, using a combination of genetic and molecular approaches in both the nematode worm C. elegans and mammalian cell culture.

Figure 2