Publications

RECENT PUBLICATIONS

  1. Merrick CJ, Dzikowski R, Deitsch K, Duraisingh MT. The effect of Plasmodium falciparum Sir2a on clonal and longitudinal variation of var gene expression. International Journal for Parasitology 40:35-43, 2010.
  2. Bei AK, DeSimone TM, Badiane AS, Ahouidi AD, Dieye T, Ndiaye D, Sarr O, Ndir O, Mboup S, Duraisingh MT. A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. American Journal of Hematology, 85:234-7, 2010.
  3. Bushkin GG, Ratner D, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O’Keefe B, Robbins PW, Samuelson J Suggestive evidence for Darwinian selection against asparagine-linked glycans of Plasmodium and Toxoplasma. Eukaryotic Cell, 9, 228-41, 2010.
  4. Ahouidi, AD, Bei AK, Neafsey DE, Sarr O, Volkman SK, Milner D, Cox-Singh J, Ferreira MU, Ndir O, Premji Z, Mboup S and Duraisingh MT. Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens. Infection, Genetics & Evolution 10:200-6, 2010.
  5. Artavanis-Tsakonas, K, Weihofen W, Antos J, Coleman BI, Comeaux C, Duraisingh M, Gaudet R, Ploegh H. Functional Diversification Between Two Members of a Plasmodium falciparum Merozoite Invasion Ligand Family is Determined by the Cytoplasmic Domain. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. Journal of Biological Chemistry, 285:6857-66, 2010.
  6. Dvorin J, Bei AK, Coleman B and Duraisingh MT. Functional Diversification Between Two Members of a Plasmodium falciparum Merozoite Invasion Ligand Family is Determined by the Cytoplasmic Domain, Molecular Microbiology, 75:990-1006, 2010.
  7. Dvorin, JD, Martyn, DC, Patel, SD, Collins, CR, Hopp, C, Grimley, JS, Bright, T, Westenberger, S, Winzeler, E, Blackman, MJ, Baker, DA, Wandless TJ, Duraisingh, MT. Knockdown of Plasmodium falciparum calcium-dependent protein kinase reveals essential step for egress. Science, 328:910-2, 2010
  8. Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Bir Sidhu A, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Krespo Llado KN, Serrano AE, Angulo-Barturen I, Jimenez-Diaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Novel inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. Journal of Biological Chemistry 285:33054-64, 2010.
  9. Bei, AK, Brugnara, C and Duraisingh MT. In vitro reverse genetic analysis of a human erythrocyte determinant of Plasmodium falciparum invasion. Journal of Infectious Diseases, 202:1722-7, 2010.
  10. Comeaux CA, Coleman BI, Bei AK, Whitehurst N, Duraisingh MT. Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth. Molecular Microbiology, 80:378-90, 2011.
  11. Barker RH Jr, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Santos Martínez M, Wittlin S, Papastogiannidis P, O’Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E. Aminoindoles: a Novel Scaffold with Potent Activity against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 55:2612-22, 2011.
  12. Broadbent K, Park D, Wolf A, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti P, Rinn J. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biology, 12:R56, 2011.
  13. Dong C, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman B, Derbyshire E, Clish CB, Serrano AE, Cromwell M, Barker Jr. RH, Dvorin JD, Duraisingh MT, Wirth D, Clardy J, Mazitschek R. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chemistry and Biology, 18:1602-10, 2011.
  14. Crosnier C, Bustamante LY, Bartholdson JY, Bei AK, Theron M, Uchikawa M, Ndir O, Mboup S, Kwiatkowski D, Duraisingh MT, Rayner JC, Wright GJ. BASIGIN is a PfRh5 receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature, 480:534-7, 2011.
  15. Farrell A, Thirugnanam S, Lorestani A, Dvorin JD, Eidell KP, Anderson-White BR, Duraisingh MT#, Marth GT# and Gubbels MJ#. A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science, 335:218-21, 2012 (# equal corresponding author)
  16. Merrick CJ, Huttenhower C, Buckee CO, Amambua-Ngwa A, Gomez-Escobar N, Walther M, Conway DJ, Duraisingh MT. Epigenetic dysregulation of virulence gene expression in severe malaria. Journal of Infectious Dieases 205:1593-600, 2012.
  17. Cessay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Tropica, 121:166-74, 2012.
  18. Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O,
  19. Okebe J, Ceesay SJ, Ngwa A, Oriero EC, Konaté L, Sy N, Jawara M, Faye O, Kéita M, Cissé M, Sogoba N, Poudiougou B, Diawara S, Sangaré L, Coulibaly T, Seck I, Abubakar I, Gomis J, Mather FJ, Sissako A, Diarra A, Kandeh B, Whalen C, Moyer B, Nnedu O, Thiero O, Bei AK, Daniels R, Miura K, Long CA, Fairhurst RM, Duraisingh M, Muskavitch MA, D’Alessandro U, Conway DJ, Volkman SK, Valim C, Wirth DF, Krogstad DJ. Improving malaria control in West Africa: Interruption of transmission as a paradigm shift. Acta Tropica, 121:175-83, 2012.
  20. Narayanasamy K, Chery L, Basu A, Duraisingh MT, Escalante A, Fowblee J, Guler JL, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, Shastri J, Smith J, Valecha N, White J, Rathod PK. Malaria Evolution in South Asia: Knowledge for Control and Elimination. Acta Tropica, 121:256-66, 2012.
  21. Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PE, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S. Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. Journal of Infection in Developing Countries, 6:727-33, 2012.
  22. Vorobjev VA, Buchholz K, Prabhat P, Ketman K, Egan E, Marti M, Duraisingh MT, Barteneva NS. Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters. Malaria Journal, 11:312, 2012
  23. Coleman, BI, Ribacke U, Manary, M, Bei, AK, Winzeler, EA, Wirth DF, Duraisingh MT. Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host and Microbe, 12:739-50, 2012.
  24. Lim C, Hansen, E, DeSimone T, Moreno Y, Unnoson K, Bei AK, Brugnara C Buckee CO, Duraisingh MT. Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nature Communications, 4:1638, 2013
  25. Engelberg K, Paul AS, Prinz B, Kono M, Ching W, Heincke D, Dobner T, Spielmann T, Duraisingh M, Gilberger TW. Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum. Biochemical Journal, 45:457-66, 2013
  26. BadianeA, Bei AK, Ahouidi AD, Patel SD, Salinas N, Ndiaye D, Sarr S, Ndir O, Tolia N, Mboup S, Duraisingh MT. Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of erythrocyte invasion pathway. Clinical and Vaccine Immunology, 20:1238-45.
  27. Patel SP, Ahouidi A, Bei AK, Mboup S, Harrison S, Duraisingh MT. Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans. Journal of Infectious Diseases, 20:1679-87.
  28. Coleman BI, Skillman KM, Jiang RH, Childs LM, Altenhofen LM, Ganter M, Leung Y, Goldowitz I, Kafsack BF, Marti M, Llinás M, Buckee CO, Duraisingh. MT. A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. Cell Host Microbe. 16:177-86, 2014.