siteheader

Marianne Wessling-Resnick

Professor of Nutritional Biochemistry

Department of Genetics and Complex Diseases
Department of Nutrition

655 Huntington Avenue
Building II Room 123
Boston, Massachusetts 02115
Phone: 617.432.3267

 

Research

Dr. Wessling-Resnick’s current research effort focuses on genetic disorders of iron metabolism at the molecular level and their implications in complex disease. She has an on-going program to establish new pharmacological tools through small molecule screening in order to identify molecular elements of iron transport. These efforts led to discovery of ferristatin, an inhibitor of transferrin-mediated iron uptake that acts by degrading the transferrin receptor. Her studies also focus on the role of iron status (deficiency and overload) in the absorption of inhaled metals. These efforts have established the pharmacokinetics of pulmonary manganese and iron uptake from the lungs to the blood and defined the influence of high iron diet as well as the effects of iron deficiency due to diet and phlebotomy. A major finding has been that anemia promotes manganese absorption across the olfactory tract into the brain, and using genetic models, her work has defined the mechanistic role of Divalent Metal Transporter-1. Her on-going investigations are support by two R01 grants from NIDDK and NIEHS.

Education

1980 – BS (Chemistry) Worcester Polytechnic Institute
1987 – PhD (Biomedical Sciences) University of Massachusetts Medical School