Professor of Medicine, HMS

We are studying the pathogenesis and therapy of HIV-1 infections. Our studies range from basic laboratory studies to clinical trials.

Therapeutic studies are evaluating drug combinations in HIV-1 infection, using both drugs directed at single targets, e.g. reverse transcriptase, and drugs directed at multiple targets. All reverse transcriptase inhibitors induce drug resistance mutations and these mutations may interact in various ways. We are exploring these interactions and attempting to develop combination strategies to delay development of multidrug resistance and attenuate virus replication. Other novel agents directed at different HIV-1 replicative sites (e.g., attachment, tat, rev) are also under study. Several clinical trials employing these concepts are being conducted in patients with HIV infection.

M.D., 1964, Johns Hopkins