Senior Research Scientist
Ph.D., Biostatistics, Harvard University, 2003
M.S., Operations Research, Cornell University, 1995
Sc.B., Applied Mathematics, Brown University, 1993
My current research interests are in statistical models and methods for infectious disease studies where infections can be transient or persistent/chronic. When diagnostic tests cannot distinguish between transient and persistent infections, there may be different ways to define the persistent infection endpoint in a natural history study or a clinical trial. Planning of such trials would benefit from assessment of several imperfect definitions of persistent infection that are based on the periodically observed infection statuses. Applications include human papillomavirus and hepatitis C virus (HCV). Another area of interest involves the predictive value of early HCV viral decline in HCV viral eradication studies of HIV co-infected persons. General areas of interest include application of multi-state models in clinical research, analysis of periodically observed data, and statistical issues in vaccine trials.