Hot topics
The following are papers recently identified by the Faculty of 1000 as notable, selected by me as of likely interest to those focused on pneumonia biology. I will be updating regularly, so please bookmark this page and check back often.
Administration of a Synthetic TLR4 Agonist Protects Mice from Pneumonic Tularemia.
J Immunol 2008 Jun 1 180(11):7574
Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection.
Nat Med 2008 May 14(5):558
NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells.
J Immunol 2008 May 15 180(10):6808
Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease.
Am J Respir Crit Care Med 2008 Mar 1 177(5):491
Leukotriene B4 Induces Release of Antimicrobial Peptides in Lungs of Virally Infected Mice.
J Immunol 2008 May 1 180(9):6211
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome.
Nature 2008 Apr 10 452(7188):773
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.
J Exp Med 2008 Mar 17 205(3):711
Surfactant protein-D and surfactant inhibit endotoxin-induced pulmonary inflammation.
Chest 2007 Nov 132(5):1447
The O antigen enables Bordetella parapertussis to avoid Bordetella pertussis-induced immunity.
Infect Immun 2007 Oct 75(10):4972
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.
Immunity 2007 Aug 27(2):349
A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity.
Science 2008 Mar 21 319(5870):1672
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science 2008 Mar 7 319(5868):1391
Global trends in emerging infectious diseases.
Nature 2008 Feb 21 451(7181):990
Lessons from the past: familial aggregation analysis of fatal pandemic influenza (Spanish flu) in Iceland in 1918.
Proc Natl Acad Sci U S A 2008 Jan 29 105(4):1303
Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia.
Nat Med 2007 Dec 13(12):1405
Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing.
PLoS Pathog 2007 Aug 24 3(8):e118
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.
Nat Med 2008 (in press)
Vaccine protection against Staphylococcus aureus pneumonia.
J Exp Med 2008 (in press)
Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.
J Exp Med 2008 205:323-9
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation.
Nat Med 2008 14:199-204
Invasive pneumococcal and meningococcal disease: association with influenza virus and respiratory syncytial virus activity?.
Epidemiol Infect 2008 Jan 23 1-7
Evidence for a heritable predisposition to death due to influenza.
J Infect Dis 2008 197:18-24
Mechanism of adenovirus neutralization by Human alpha-defensins.
Cell Host Microbe 2008 3:11
Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages.
Proc Natl Acad Sci USA 2008 105:1009
Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication.
Proc Natl Acad Sci U S A 2006 103:14578
An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment.
J Immunol 2007 179:7791
Intranasal interleukin-12 therapy inhibits Mycoplasma pneumoniae clearance and sustains airway obstruction in murine pneumonia.
Infect Immun 2008 76:732
Respiratory Syncytial Virus Infection and Disease in Infants and Young Children Observed from Birth in Kilifi District, Kenya.
Clinical infectious diseases 2008 46:50
Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia.
Cell Host Microbe 2007 2:240
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
J Virol 2008 82:335
Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia.
J Exp Med 2007 204:2759
The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivo.
J Immunol 2006 177:519
Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumonia.
Am J Respir Crit Care Med 2007 176:913
The impact of emergency department crowding measures on time to antibiotics for patients with community-acquired pneumonia.
Ann Emerg Med 2007 50:510
Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA.
Nat Med 2007 (in press)
Fc{gamma}RIII is Protective Against Pseudomonas aeruginosa Pneumonia.
Am J Respir Cell Mol Biol 2007 (in press)
The association between pneumococcal pneumonia and acute cardiac events.
Clin Infect Dis 45:158-65, 2007
Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004.
J Infect Dis 196:1346-54, 2007
Prospective multinational study of pertussis infection in hospitalized infants and their household contacts.
Pediatr Infect Dis J 26:238-42, 2007
Effects of systemic steroids in patients with severe community-acquired pneumonia.
Eur Respir J (in press) 2007 Aug 9
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.
J Exp Med 2007 Oct 1 204(10):2407-22
Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children.
JAMA 2007 Oct 17 298(15):1772-8
Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial.
Lancet 2007 Aug 18 370(9587):580-9
Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parent-collected specimens.
Pediatrics 2007 Oct 120:929-37
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Immunity 2007 Aug 27(2):240-52
Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination.
J Immunol 2007 Oct 1 179(7):4711-20
Differential contribution of bacterial fMLP and host-derived CXC chemokines on neutrophil infiltration into pulmonary alveoli during murine pneumococcal pneumonia.
Infect Immun 2007 (in press)
Role of environmental surveillance in determining the risk of hospital-acquired legionellosis: a national surveillance study with clinical correlations.
Infect Control Hosp Epidemiol 2007 Jul 28(7):818-24
The value of computed tomography-guided percutaneous lung biopsy for diagnosis of invasive fungal infection in immunocompromised patients.
Clin Infect Dis 2007 Oct 1 45:101-4
Contribution of a pleural antigen assay (Binax NOW) to the diagnosis of pneumococcal pneumonia.
Chest 2007 May 131(5):1442-7
The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection.
J Exp Med 2007 Aug 6 204(8):1901-9
Small self-RNA generated by RNase L amplifies antiviral innate immunity.
Nature 2007 Aug 16 448(7155):816-9
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Nature 2007 Jul 26 448(7152):501-5
A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients.
Proc Natl Acad Sci U S A 2007 Jun 26 104(26):11020-5
Perinatal and crowding-related risk factors for invasive pneumococcal disease in infants and young children: a population-based case-control study.
Clin Infect Dis 2007 Apr 15 44(8):1051-6
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study.
Arch Intern Med 2007 Aug 13-27 167(15):1655-63
Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia.
Am J Respir Crit Care Med 2007 Jul 15 176(2):162-6
Human lung innate immune response to Bacillus anthracis spore infection.
Infect Immun 2007 Aug 75(8):3729-38
Nod1 mediates cytoplasmic sensing of combinations of extracellular bacteria.
Cell Microbiol 2007 May 9(5):1343-51
Wurst is essential for airway clearance and respiratory-tube size control.
Nat Cell Biol 2007 Jul 9(7):847-53
Effect of Dexamethasone and ACC on Bacterial Induced Mucin Expression in Human Airway Mucosa.
Am J Respir Cell Mol Biol 2007 Jun 28
A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans.
Proc Natl Acad Sci U S A 2007 Jul 3 104(27):11424-9
Mass distribution of free, intranasally administered influenza vaccine in a public school system.
Pediatrics 2007 Jul 120(1):e172-8
Development and testing of a rapid diagnostic test for bubonic and pneumonic plague.
Lancet 2003 Jan 18 361(9353):211-6
Targeting Host Cell Furin Proprotein Convertases as a Therapeutic Strategy against Bacterial Toxins and Viral Pathogens.
J Biol Chem 2007 Jul 20 282(29):20847-53
Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass.
Blood 2004 Dec 1 104(12):3758-65
The above image links to a free UNICEF/WHO publication available as a pdf, a call to action to raise awareness and reduce child mortality from pneumonia.
