Molly Kile

Visiting Scientist

Department of Environmental Health

Department of Environmental Health

665 Huntington Avenue
Boston, MA 02115

Research

Dr. Kile is interested in environmental and molecular epidemiology. Specifically, her research has focused on 1) the application of biological markers for studying exposures to both essential and non-essential metals, 2) the interaction between host factors (genetic polymorphisms, nutritional status) and environmental exposures. She has an active interest in international environmental health studies and projects on water and health.

Current research projects include:

1)    Arsenic and Reproductive Health in Bangladesh – a prospective study that will investigate the effects of arsenic exposure on reproductive outcomes including birth weight.

2)    Arsenic, Folate, and Skin Disease – evaluate the interaction between arsenic, folate, and folate genes on non-cancerous skin lesions in a case-control study conducted in Bangladesh.

In addition, she is the instructor for Principles of Environmental Health, a case-based course that introduces graduate students to the field of environmental health.

Publications

Selected peer-reviewed publications-

Kile,M.L., Houseman, E.A., Breton, C.V., Smith, T.J., Quamruzzaman, Q., Rahman, M., Mahiuddin, G., Christiani, D.C. (2007) Association between total ingested arsenic and toe nail arsenic concentrations. J. Environmental Science and Health, Part A, Vol. A42, No. 12. (In press).

Breton,C.V., Zhou, W., Kile, M.L., Houseman, E.A., Quamruzzaman, Q. Rahman, M., Mahiuddin, G., Christiani, D.C. (2007) Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes. Carcinogenesis, (In press).

Kile,M.L., Houseman, E.A., Breton, C.V., Smith, T.J., Quamruzzaman, Q., Rahman, M., Mahiuddin, G., Christiani, D.C. (2007) Dietary Arsenic Exposure in Bangladesh. Environmental Health Perspectives, 115(6):889-893.

Breton, C.V., Houseman, E.A., Kile, M.L., Quamruzzaman, Q., Rahman, M., Mahiuddin, G., Christiani, D.C. (2006) Gender-specific protective effect of hemoglobin on arsenic-induced skin lesions. Cancer Epidemiology Biomarkers & Prevention, 15(5): 902-907.

Ford, T., Jay, J., Patel, A., Kile, M.L., Prommasith, P., Galloway, T., Sanger, R., Smith, K., Depledge, M. (2005) Use of ecotoxicological tools to evaluate the health of New Bedford Harbor sediments: A microbial biomarker approach. Environmental Health Perspectives, 113(2): 186-191.

Kile, M.L., Houseman, E.A., Rodrigues, E., Smith, T.J., Quamruzzaman, Q., Rahman, M., Mahiuddin, G., Su, L., Christiani, D.C. (2005) Toenail arsenic concentrations, GSTT1 gene polymorphisms, and arsenic exposure from drinking water. Cancer Epidemiology Biomarkers & Prevention, 14(10): 2419-2426.

McCarty, K.M., Senn, D.B., Kile, M.L., Quamruzzaman, Q., Rahman, M., Mahiuddin, G., Christiani, D.C. (2004) Antimony: An unlikely confounder in the relationship between well water arsenic and health outcomes in Bangladesh. Environmental Health Perspectives, 112(8): 809-811

Books and Monographs-
Matveev, N. and Kile, M.L. Chapter 95: Pigmentation changes as a result of arsenic exposure. In Dermatotoxicology, Eds. Marzulli and Maibach. Boca Raton, CRC Press, p.871-876. (In press)