Ulcerative Colitis in Mice
Podcast: What Causes Ulcerative Colitis in Mice and What Does This Discovery Mean for Humans? Laurie Glimcher, Irene Heinz Given Professor of Immunology, and Wendy Garrett, Research Fellow, on likely cause of ulcerative colitis in mice. Please use the buttons to the right to play this podcast in your browser: Alternatively, you may click here to download the podcast in mp3 format. Duration: 4:07 |
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| Video: What Causes Ulcerative Colitis in Mice and What Does This Discovery Mean for Humans? In a series of mouse experiments, researchers at the Harvard School of Public Health (HSPH) have pinpointed a specific immune deficiency as the likely fundamental cause of ulcerative colitis, a chronic, sometimes severe inflammatory disease of the colon or large intestine that afflicts half a million Americans. Watch a slide demonstration of how harmful bacteria penetrate the bowel's protective lining and trigger damaging inflammation. Then listen to HSPH Professor Laurie Glimcher and Research Fellow Wendy Garrett describe the implications of this research. |
Accompanying paper to be published in Cell 131, 1-13, October 5, 2007. Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System. Wendy S. Garrett, Graham M. Lord, Shivesh Punit, Geanncarlo Lugo-Villarino, Sarkis K. Mazmanian, Susumu Ito, Jonathan N. Glickman, and Laurie H. Glimcher.
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