- Interactions of nanoparticles with biological systems
Nanoparticles are employed everyday in commodities and advanced sophisticated applications. Here, we study their interactions with biological systems in-vitro and in-vivo in order to obtain a fundamental understanding of their effect. Based on this understanding we design nanostructured materials that possess all desired properties but do not pose risks to the environment and human health.
- Nanoparticles exhibitting surface plasmon resonance used in biosensing and bioimaging
Certain metals (e.g. Au, Ag) exhibit a surface plasmon resonance upon their interaction with light when they are in the nanometer sizes. These nanoparticles can be used as “tools” for bioapplications. We synthesize such nanoparticles and find ways to optimize their performance.
- Advanced multifunctional nanocomposites
Polymer matrixes play important roles in many areas, however, more often than not, they need nanoparticles as fillers for superior performance, and thus nanocomposites are made. We synthesize such filler nanoparticles for high-tech applications and investigate their dispersion in selected polymers.
- Luminescent nanoparticles
Nanoparticles that emit light light upon excitation (e.g. nanophosphors, quantum dots) find potential applications in high-definitition display panels, lighting, bioimaging, to name a few. Here, we synthesize such nanoparticles and investigate the parameters that influence their luminescence, targeting superior performance in biomedical applications.
If you like one of the above research areas, do not hesitate to contact me. Possible internship projects (e.g. Master thesis) may be available!
- A. Pratsinis, P. Hervella, J-C. Leroux, S.E. Pratsinis, G.A. Sotiriou*, “Toxicity of Silver Nanoparticles in Macrophages”, Small in press, doi: 10.1002/smll.201202120 (2013). link
- S. Gass, J. Cohen, G. Pyrgiotakis, G.A. Sotiriou, S.E. Pratsinis, P. Demokritou, “Safer Formulation Concept for Flame-Generated Engineered Nanomaterials”, ACS Sustainable Chem. Eng. in press, doi: 10.1021/sc300152f (2013). link
- G.A. Sotiriou, C.O. Blattmann, S.E. Pratsinis, “Flexible, Multifunctional, Magnetically Actuated Nanocomposite Films”, Adv. Funct. Mater. 23, 34-41 (2013). link
- G.A. Sotiriou*, D. Franco, D. Poulikakos, A. Ferrari, “Optically Stable Biocompatible Flame-Made SiO2-Coated Y2O3:Tb3+ Nanophosphors for Cell Imaging”, ACS Nano 6, 3888–3897 (2012). link
- Y. Deligiannakis, G.A. Sotiriou, S.E. Pratsinis, “Antioxidant and Antiradical SiO2 Nanoparticles Covalently Functionalized with Gallic Acid”, ACS Appl. Mater. Interfaces 4, 6609-6617 (2012). link
- G.A. Sotiriou, E. Diaz, M. S. Long, J. Godleski, J. Brain, S.E. Pratsinis, P. Demokritou, “A Novel Platform for Pulmonary and Cardiovascular Toxicological Characterization of Inhaled Engineered Nanomaterials”, Nanotoxicology 6, 680-690 (2012). link
- G.A. Sotiriou, A. Hirt, P.-Y. Lozach, A. Teleki, F. Krumeich, S.E. Pratsinis, “Hybrid Silica-coated, Janus-like Plasmonic-Magnetic Nanoparticles”, Chem. Mater. 23, 1985-1992 (2011). link
- G.A. Sotiriou, T. Sannomiya, A. Teleki, F. Krumeich, J. Vörös, S.E. Pratsinis, “Non-toxic, Dry-coated Nanosilver for Plasmonic Biosensors”, Adv. Funct. Mater. 20, 4250-4257 (2010). Frontispiece of issue published 21 Dec 2010 link
- G.A. Sotiriou, S.E. Pratsinis, “Antibacterial Activity of Nanosilver Ions and Particles”, Environ. Sci. Technol. 44, 5649-5654 (2010). link