Bios

Alberto Ascherio, M.D., Dr.P.H.

Dr. Ascherio’s current research is focused on the epidemiology of neurological diseases, including multiple sclerosis (MS), Parkinson’s disease (PD), and stroke. Data used in his research originate from several large ongoing prospective cohorts, including the 121,700-member Nurses’ Health Study, the Health Professionals Follow-up Study, a cohort of 52,000 men; the Nurses’ Health Study II, a cohort of younger women numbering 116,000, and the Cancer Prevention Study II Nutrition cohort, comprising over 160,000 men and women. An ongoing investigation on the role of infection in the etiology of MS takes advantage of a serum repository maintained by the Department of Defense with archived samples from over 3 million people. Examples of recent research findings include a positive relationship between Epstein-Barr virus infection and risk of MS, an increased risk of MS among smokers, and inverse associations between use of non-steroidal anti-inflammatory drugs and caffeine consumption and Parkinson’s disease. Ongoing research includes a longitudinal study of ALS, and the investigation of dietary determinants of coronary heart disease and peripheral arterial disease. Dr. Ascherio has also conducted epidemiological research in developing countries including a study on child mortality in Iraq , a survey on victims of land mines in Mozambique, studies on chronic diseases in India, and an investigation on child nutrition and mortality in Brazil.

For more information, please visit Dr. Ascherio’s faculty web site.

Marc Weisskopf, Ph.D., Sc.D.

Marc’s research interests mostly come from his background in neurobiology. He is interested in how environmental factors affect the nervous system, as well as the epidemiology of neurologic disorders. Currently, one focus of his research is cognitive function. In particular, how non-occupational exposure to environmental lead affects cognitive function in a general elderly population, and how this may be modified by particular genetic polymorphisms; as well as how lifestyle factors and particular genetic polymorphisms affect cognitive decline in persons with Parkinson’s disease. He is co-investigator on a grant to look at the association between risk of Parkinson’s Disease and organochlorines in serum collected prospectively, as well as on another grant to look at risk factors for amyotrophic lateral sclerosis (ALS) mortality using the American Cancer Society’s Cancer Prevention Study II cohort. This is the largest prospective cohort study of risk factors for ALS as the population is over 1 million.

For more information, please visit Marc’s webpage.

Xing Yang, M.D. Ph.D.

Curriculum Vitae

 
NAME Xing Yang  POSITION TITLE       Research Associate 
Contact: Email: xyang@hsph.harvard.edu
EDUCATION/TRAINING
INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY
Osaka University Graduate School of Medicine Ph D      2000 Medical Sciences
Shanghai Medical University MD      1993 Preventive Medicine
         

   A. RESEARCH AND PROFESSIONAL EXPERIENCE

09/2005-Present Research Associate, Department of Nutrition, Harvard School of Public Health
 
  • Investigating the association between Epstein Barr Viral infection and Multiple Sclerosis.
04/2001-08/2005 Research Fellow, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
 
  • Identifying the Robo1 binding proteins in human leukocyte by yeast two-hybrid.
  • Discovering the functional importance and clinical application potential of a novel breast cancer marker-SMARCAD1.
  • Defining the role of HTm4 as a new central nervous system development maker-, including examining HTm4 expression profile in embryonic murine brain and building transgenic HTm4 expression animal models.
  • Studying the cell cycle regulator role of HTm4 in hematopoietic/immunologic system by different in vivo or in vitro models including generating HTm4 knockout mice.
   
07/2000-03/2001 Research Associate, Laboratory of Molecular Medicine, Human Genome Center, The University of Tokyo Institute of Medical Science, Tokyo, Japan
 
  • Investigated the gene expression profile of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome by cDNA miroarray.
  • Conducted studies on other immune diseases, such as Wiskott-Aldrich syndrome.
   
07/1993-07/1995 Instructor, Laboratory of Hematology/Oncology, Shanghai Medical University Institute of Radiation Medicine, Shanghai, PR China
 
  • Studied the radiosensitivity prediction of nasopharyngeal carcinoma.

    B. HONORS AND AWARDS

1998-2000 Scholarship, Kashiyama Foundation
1996-1997 Scholarship, Osaka Prefecture and Osaka Foundation of International Exchange, Japan

   

C. PUBLICATIONS

  Original Articles: 

  1. Yang, X.*,Chinami, M.*, Yano, Y.*, Salahuddin, S., Turner, H., Shirakawa, T., Barford, D., and Adra, C. N. (2005) J Biol Chem Epub. 280, 17235-17242 Co-1st authors.
  2. Yang, X. *, Kutok, J. L. *, Folkerth, R. D., Imitola, J., Raddassi, K., Yano, Y., Salahuddin, S., Shirakawa, T., Turner, H., Khoury, S., Sayegh, M. H., Scadden, D. T., and Adra, C. N. (2005) J Mol Histology,36:77-87.  Co-1st authors.
  3. Shimada, T., Cheng, L., Enomoto, T., Yang, X., Miyoshi, A., and Shirakawa, T. (2004) J Investig Allergol Clin Immunol 14, 187-192
  4. Nakajima, T., Iikura, M., Okayama, Y., Matsumoto, K., Uchiyama, C., Shirakawa, T., Yang, X., Adra, C. N., Hirai, K., and Saito, H. (2004) J Allergy Clin Immunol 113, 528-535
  5. Narita, M., Kitagawa, K., Nagai, Y., Hougaku, H., Hashimoto, H., Sakaguchi, M., Yang, X., Takeshita, T., Morimoto, K., Matsumoto, M., and Hori, M. (2003) Ultrasound Med Biol 29, 1415-1419
  6. Takeshita, T., Yang, X., and Morimoto, K. (2001) Alcohol Clin Exp Res 25, 1264-1269
  7. Yang, X., Takeshita, T., Hirata, M., Sato, S., and Morimoto, K. (1999) Alcohol Clin Exp Res 23, 751-756
  8. Takeshita, T., Yang, X., Inoue, Y., Sato, S., and Morimoto, K. (2000) Cancer Lett 149, 69-76
  9. Takeshita, T., Yang, X., and Morimoto, K. (2000) Hum Genet 106, 589-593

    Reviews: 1.      Adra CN, Mao XQ, Yang X, Gao PS, Hopkin JM and Shirakawa T:  Chromosome 11q13, FceR1B and Atopic Asthma.  In Hereditary basis of allergic diseases. Edited by ST Holgate and J Holloway. Birkhauser Verlag, Basel, 2002, Pages 85-942.      Gao, P. S., Mao, X. Q., Hopkin, J. M., Adra, C. N., Yang, X., and Shirakawa, T. (2000) Clin Exp Allergy 30, 1672-1675  D. Abstracts: 1.         Yang X, Kutok J, Raddassi K, Salahuddin S, Nakajima T, Saito H, Aster J, Scadden D, Adra C. Gene and tissue microarray analysis of HTm4 expression in peripheral blood cells and normal and malignant tissues. (2004) 95th American Association for Cancer Research Annual Meeting. 2.         Yang, X., Nakajima, T., Iikura, M., Okayama, Y., Matsumoto, K., Uchiyama, C., Shirakawa6, T., Hirai, K., Saito, H., and Adra, C. Identification of Granulocyte Subtype-selective Receptors and Ion Channels by High-Density Oligonucleotide Probe Array. (2004) 2004 Annual Meeting of the American Academy of Allergy, Asthma, and Immunology 3.         Kutok, J., Yang, X., Salahuddin, S., Badovinac, R., Imitola, J., Raddassi, K., Lebedeva, T., Folkerth, R., Donato, J., Lim, K., Abbott, J., Chinami, M., Saito, H., Shirakawa, T., Lawitts, J., Sayegh, M., Khoury, S., Scadden, D., and Adra, C. HTm4 is a marker of hematopoiesis and early central nervous system development in mouse: cloning, genomic organization, protein expression and functional characterization of the murine homologue of human HTm4. (2003) 45th American Society of Hematology Annual Meeting 4.         Adra, C., Carlo, V., Badovinac, R., Hairston, J., Yang, X., Yano, Y., Shirakawa, T., Drews, R., Schnitt, S., and Schnipper, L. SMARCAD1 protein is under expressed in invasive breast cancer. (2003) 94th American Association for Cancer Research Annual Meeting  5.         Adra, C., Carlo, V., Yang, X., Badovinac, R., Salahuddin, S., Drews, R., Schnitt, S., and Schnipper, L. Underexpression of Human Helicase SMARCAD1 is Associated with Breast Carcinoma Progression. (2003) American Association for Cancer Research Annual Meeting Special Meetings:Advances in Breast Cancer Research: Genetics, Biology, and Clinical Implications  E. Professional Membership: International Society for Stem Cell Research 

 

Erin Beck

Erin joined the Neuroepi group in 2008 as a research assistant for the NHS II study on autism.  She completed her undergraduate work at BYU where she double majored in Physiology and English Literature and worked in the human cadaver lab.  She received an MPH from Boston University in 2011, with an emphasis in International Health and Development.

Michael A. Schwarzschild, M.D. Ph.D. (US)

After obtaining his undergraduate degree in biochemistry at Princeton University, Michael Schwarzschild went on to medical and graduate neuroscience training at Harvard Medical School. There he pursued his PhD thesis with Dr. Richard Zigmond on the neurochemistry of tyrosine hydroxylase, the enzyme controlling dopamine biosynthesis. He next undertook neurology residency and then Parkinson’s disease fellowship training at Massachusetts General Hospital in Boston under the guidance of Drs. Anne Young and John Growdon. During a postdoctoral research fellowship with Dr. Steve Hyman in the mid-90′s, he developed expertise in gene regulation and cell death pathways in the basal ganglia (the dopamine-rich brain region most affected in Parkinson’s disease).

Since 1996 Dr. Schwarzschild has directed the Molecular Neurobiology Laboratory at the MassGeneral Institute for Neurodegenerative Disease at MGH, focusing on the role of three purines (adenosine, caffeine and urate) in animal models of PD. Together with Dr. Jiang-Fan Chen he discovered the neuroprotective properties of adenosine A2A receptor blockers (including caffeine) in mouse models of the disease. His research team then provided evidence that these drugs may help prevent dyskinesia, a side effect of standard antiparkinsonian therapy. His leadership of a series of international research conferences in 2002 and 2006 on A2A receptors in Parkinson’s has helped translate our understanding of this drug target into an promising new therapy for Parkinson’s patients.

Most recently, through a fruitful interdisciplinary collaboration with epidemiologist Dr. Alberto Ascherio and his team at the Harvard School of Public Health, Dr. Schwarzschild and his colleagues have discovered an unprecedented clue to why disease progression is mild in some and aggressive in others. In partnership with the Parkinson Study Group (PSG) they showed that the purine antioxidant urate can serve as a predictor of not only the risk of PD, but also the rate at which it progresses. Their work identifies urate as a molecular biomarker of PD progression rate, and as a candidate neuroprotective agent too. The convergent epidemiological and clinical data have led to development of a major national clinical trial for which he serves as PI.

Dr. Schwarzschild has been the recipient of the George C. Cotzias career award from the American Parkinson’s Disease Association and the Paul Beeson Physician Faculty Scholar award from the American Federation for Aging Research. Since 1997 he has been an active clinical investigator in therapeutic trials of the PSG. He is currently an Associate Professor of Neurology at Harvard Medical School and a staff physician on the Neurology Service at Massachusetts General Hospital, where he works with Parkinson’s patients and their families in his weekly movement disorders clinic.

Xiang Gao, M.D., Ph.D., M.S.

Dr. Gao’s current research aims to investigate relationships between environmental/dietary factors and risk of neurological deceases, including Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). Data from several large ongoing prospective cohorts have been used, including Nurses’ Health Study, and Health Professionals Fellow-up Study.

Download CV.

Hao Wang, Ph.D.

Hao received her PhD degree from the University of Heidelberg, Germany in 2005, and then joined the Neuroepidemiology group as a research fellow in 2006. Her primary area of research is the study of the potential protective effects of vitamin E and other dietary antioxidants on amyotrophic lateral sclerosis (ALS), based on data from large-scale longitudinal studies. She is also involved in studies on MS and Parkinson’s disease.

Kristen Lyall

Kristen joined the neuroepi group as a doctoral student in 2005 to help initiate a study of autism spectrum disorders. She investigated maternal risk factors for autism spectrum disorders in her doctoral thesis. Currently, she is a postdoctoral research fellow at the UC Davis MIND Institute, and continues work with the neuroepi lab as a Visiting Scientist examining maternal reproductive, lifestyle, and dietary factors in association with autism and related conditions. 

Xing Yang, M.D. Ph.D.

Dr. Yang joined our team as a Research Associate in September of 2005.  His current research is focused on investigating the association between Epstein Barr Viral infection and multiple sclerosis.

 Download CV

Jennifer Massa

Jennifer started working at the Harvard School of Public Health in the environmental health department where she did field sampling and lab work.  She then moved to Johns Hopkins School of Public Health, where she became the project coordinator for a study investigating the health effects on the clean up crews at the World Trade Center disaster site.  She came back to Harvard to pursue her doctor of science in epidemiology and nutrition and worked on the Nurses’ Health Study II colon polyp project.  She is currently a post doctoral research fellow in pursuing her research interests in risk factors for multiple sclerosis.

Fariba Mirzaei, M.D.

Fariba joined the group in 2004 when she started the doctoral program in nutritional epidemiology. She is a physician from Iran and began working on multiple sclerosis in Iran as a research topic for her MPH degree. She is currently studying the perinatal risk factors for MS.

She has also been working as the project coordinator for the depression project in the Nurses’ Health Study II since 2004.

Evan Thacker

Evan completed his bachelors degree in neuroscience at Brigham Young University and his masters degree in epidemiology here at HSPH.  His masters thesis was a study of possible side effects of Alzheimer’s disease drugs in patients with concomitant lung disease.  Since 2005, most of his research in the HSPH neuroepidemiology group has focused on behavioral factors related to Parkinson’s disease, including smoking and physical activity, in the Cancer Prevention Study II Nutrition Cohort.  He lives in Brookline, MA, with his wife and son.

Natalia (Morozova) Palacios, Sc.D.

Natalia received her doctorate in Nutritional Epidemiology from HSPH in 2008. She obtained her undergraduate degree from Rice University, where she majored in Biochemistry. She is currently a post-doctoral research fellow in Environmental Epidemiology.

Natalia is interested in the epidemiology of ALS and Parkinson’s disease. Her projects have included Analyses of Diet and ALS in the CPS II cohort, Study of Trends in Male to Female ratios of smoking and Parkinson’s disease, and ALS follow-up in the Nurses’ Health Study. She has also studied interactions between caffeine and estrogen metabolizing genes and caffeine intake in the Nurses’ Health Study and the Health Professionals Follow-up Study. Natasha is currently working on environmental and genetic risk factors of Parkinson’s disease.

Natalia also has a strong interest in Nutrition policy and is co-instructor of Nut 226 – Seminar of Nutrition Policy, at HSPH.

Her hobbies include tennis, running, yoga, and reading, and she speaks fluent French and Russian.

Kassandra Munger, Sc.D.

After receiving her masters degree in epidemiology from the University of Massachusetts, Amherst, in 2001, Kassandra came to the Harvard School of Public Health as the project coordinator/director of the multiple sclerosis studies in the neuroepidemiology group. In 2004, she enrolled in the doctoral program in nutritional epidemiology, which she completed in 2009, and she continues to serve as the MS project director.  Her main research area of interest is how diet, especially vitamin D, may affect the risk and progression of MS and type 1 diabetes.  She has also been actively involved in studies examining whether infection with Epstein-Barr virus or Chlamydia pneumonia increase MS risk.

Éilis O’Reilly, Sc.D.

Éilis is a post-doctoral research associate in the neuroepi group. Her substantive research areas include the long-term effects of diet, other life-style habits, and environmental exposures on the incidence of neurological disease. Her methodological interest is in methods for drawing causal inferences from longitudinal data with time-varying exposures. She also has a keen interest in the implementation of public health initiatives and policy following epidemiological discovery.

Leslie Unger

Leslie joined our team as a staff assistant in the fall of 2005.  She received her B.A. from UC Berkeley with a major in Spanish and a minor in music.  Leslie studied abroad in Barcelona, Spain, and also spent time in Seoul, South Korea.  She speaks fluent Spanish and intermediate Korean.  She is currently taking classes in psychology.

Lauren Borchardt, MPH

Lauren joined the neuroepi group as a project coordinator in May 2005, after receiving her masters in public health with a concentration in chronic disease epidemiology from Yale University. While at Yale, her research interests included dietary risk factors for esophageal cancer, and measurement techniques for assessing carotenoid intake. Prior to that, she worked at the Dana Farber Cancer Institute as a data manager for a study focused on women at high risk of breast and/or ovarian cancer.