LEAD INVESTIGATOR Professor of Epidemiology Megan Murray aims to find
out just how virulent extensively drug-resistant TB strains might be in
healthy people.
TB Super Strains
Few outsiders had ever heard of the rural district of Tugela Ferry, 200 square kilometers of arid scrubland in South Africa’s
KwaZulu-Natal Province, before a frightening
outbreak began unfolding there in 2005: At the Church of Scotland
hospital, a group of patients suddenly began dying—succumbing, as it
turned out, to a tuberculosis “super-bug.”
Similar scattered cases had been recorded by the U.S. Centers for
Disease Control and Prevention (CDC) but Tegula
Ferry’s outbreak had no precedent. Of 53 people identified
as carrying this strain, most of them HIV positive, 52 died. Alarmed,
the CDC sped up one multinational TB survey and released the results in
March of 2006. Officials christened the deadly disease “extensively”
drug-resistant tuberculosis, or XDR-TB. News reports encircling the
globe called it “virtually untreatable.” No one knows precisely how virulent XDR-TB might be among healthy
people whose immune systems aren’t already enfeebled. But researchers at the Harvard School of Public Health (HSPH) aim to find
out. Driving the School’s effort is Principal Investigator Megan
Murray, an assistant professor at Harvard Medical School and an
associate professor of epidemiology at HSPH. more
On May 2, Cyclone Nargis hit the coast of Myanmar. Ten days later, an
earthquake struck China's mountainous Sichuan Province. Both events
left thousands dead, missing, injured, and homeless, and focused the
world's attention on the actions of China's and Myanmar's governments. more
A new checklist unveiled on June 25 by the World Health Organization
(WHO) and collaborators at the Harvard School of Public Health should
help prevent avoidable deaths and disability in operating rooms
worldwide. more
To make health insurance more affordable and accessible, reform the
federal tax code, says HSPH Professor of Health Economics Katherine
Baicker. more
Monica Ter-Minassian is scouring the genome for time bombs. Using
gene-reading technology and analytic techniques, this HSPH doctoral
student is on the hunt for subtle variations in human DNA that might
help identify the causes of rare neuroendocrine and esophageal tumors,
or provide a deeper understanding of why smoking provokes lung cancer
in some people but not in others. more