An article published in Nature by Gökhan S. Hotamisligil, chair of HSPH’s Department of Genetics and Complex Diseases and James S. Simmons Professor Genetics and Metabolism, has been selected by Essential Science Indicators, a compilation of science performance statistics and science trends data based on journal article publication counts and citation data, as one of the most-cited papers in the research area of clinical medicine. The article, “Inflammation and metabolic disorders,” appeared in the December 2006 issue of Nature.
Hotamisligil discusses the paper and his views on the future of his research in an October 2010 interview posted on thewebsite ScienceWatch. The cited paper represents the culmination of Hotamisligil’s life’s work on the interactions between metabolic homeostasis and immune response. “I have tried to provide the framework on how metabolic alterations and a unique form of chronic inflammatory response are so intimately related and so important for health,” Hotamisligil tellsScienceWatch. “I believe the recognition of this paper reflects the excitement in the field about inflammation and our contributions to that field.” He adds, “Chronic metabolic diseases are now the leading cause of mortality and morbidity around the world. The burden they place on human health and cost of health care is enormous.”
The Mystery of the Metabolic Supermice (Harvard Public Health Review, Winter 2007)