Leonard Guarente

In 2000, Guarente discovered a specific link in yeast between eating less and living longer. He identified a cellular mechanism in which calorie restriction activates a gene called SIR2, apparently slowing aging for the duration of the low-calorie diet. Later, Guarente demonstrated that SIR2 serves a similar function in roundworms. His group is now investigating the role of the gene in mice. Humans possess a gene similar to SIR2.

"There have been a number of very exciting developments in investigating the genetics and molecular biology of aging," said Dean Barry Bloom. "Dr. Guarente’s approach to this research will likely prove more and more powerful as we look at the basis for premature aging and longevity. Work in this field should be of interest not only from a bench science perspective, but also from epidemiological and social science perspectives."

The Dean’s Distinguished Lecture Series draws scientific leaders to HSPH to address crosscutting research. The inaugural lecture in December, held jointly with the Department of Epidemiology’s Cutter Lecture, featured noted economist Jeffrey Sachs, who spoke on reducing global poverty.

Most recently, Guarente co-authored a paper in the January 1 issue of Genes & Development that further elucidated how SIR2 is activated in yeast. Calorie restriction appears to inhibit the activity of a specific enzyme, allowing a series of biochemical steps that increases stimulation of Sir2, the protein made by the gene SIR2.