Results of some large prospective studies of alcohol consumption and cardiovascular disease
| Name, participants (date of publication) | Duration |
Association with moderate alcohol consumption* |
| Japan Collaborative Cohort Study for Evaluation of Cancer Risk cohort: 97,432 men and women aged 40 to 79 (2005) | 10 years | 12%-20% decreased risk of all-cause mortality in men and women who consumed less than 23 grams per day of alcohol; heavy drinking increased the risk of all-cause mortality (1) |
| Health Professionals Follow-up Study: 38,077 male health professionals aged 40-75 (2003) | 12 years | 35% reduced risk of myocardial infarction (2) |
| Eastern France cohort: 34,014 men and women (1999) |
10–15 years |
25-30% reduced risk of cardiovascular death (3) |
| Cancer Prevention Study II: 489,626 men and women aged 30-104 (1997) | 9 years | 30-40% reduced risk of cardiovascular death; mortality from all causes increased with heavier drinking, particularly among adults under age 60 (4) |
| Physicians' Health Study: 22,071 male physicians aged 40-84 (1997) | 11 years | 30-35% reduced risk of angina and myocardial infarction, 20-30% reduced risk of cardiovascular death (5, 6) |
| Kaiser Permanente cohort: 123,840 men and women aged 30+ (1990) | 10 years | 40% reduction in fatal myocardial infarction, 20% reduction in cardiovascular mortality; 80% increase in fatal hemorrhagic stroke (7) |
| Nurses' Health Study: 85,709 female nurses aged 34-59 (1988) | 12 years | 17% lower risk of all-cause mortality; an earlier report showed a 40% reduction in risk of CHD and 70% reduction in risk of ischemic stroke (8) |
* compared with non-drinkers
References
1. Lin Y, Kikuchi S, Tamakoshi A, et al. Alcohol consumption and mortality among middle-aged and elderly Japanese men and women. Ann Epidemiol. 2005; 15:590-97.
2. Mukamal KJ, Conigrave KM, Mittleman MA, et al. Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med. 2003; 348:109-18.
3. Renaud SC, Gueguen R, Siest G, Salamon R. Wine, beer, and mortality in middle-aged men from eastern France. Arch Intern Med. 1999; 159:1865-70.
4. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med. 1997; 337:1705-14.
5. Camargo CA, Jr., Hennekens CH, Gaziano JM, Glynn RJ, Manson JE, Stampfer MJ. Prospective study of moderate alcohol consumption and mortality in US male physicians. Arch Intern Med. 1997; 157:79-85.
6. Camargo CA, Jr., Stampfer MJ, Glynn RJ, et al. Prospective study of moderate alcohol consumption and risk of peripheral arterial disease in US male physicians. Circulation. 1997; 95:577-80.
7. Klatsky AL, Armstrong MA, Friedman GD. Risk of cardiovascular mortality in alcohol drinkers, ex-drinkers and nondrinkers. Am J Cardiol. 1990; 66:1237-42.
8. Stampfer MJ, Colditz GA, Willett WC, Speizer FE, Hennekens CH. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med. 1988; 319:267-73.