Philippe Grandjean

Philippe Grandjean

Adjunct Professor of Environmental Health

Department of Environmental Health

401 Park Drive
Landmark Center Room 3-110 East
Boston, Massachusetts 02215
Phone: 617.384.8907

Research

Philippe Grandjean was born in Denmark in 1950. He graduated with his MD from the University of Copenhagen at age 23, and six years later he defended his doctoral thesis on the ‘Widening perspectives of lead toxicity’. He became Professor of Environmental Medicine at the University of Southern Denmark in 1982. A Fulbright Senior Scholarship award brought him to Mt.Sinai Hospital in New York, and he later served as Adjunct Professor of Neurology and Environmental Health at Boston University. In 2003, he became Adjunct Professor of Environmental Health at Harvard University. In 2004, he received an unusual recognition – the Mercury Madness Award for excellence in science in the public interest, from eight US environmental organizations. He lives in Copenhagen, Denmark and in Cambridge, MA, and travels widely to study environmental problems and to examine children whose lives have been affected by pollution, more specifically, the delayed effects of developmental exposure to environmental chemicals.

His most recent projects  examine general development and immunotoxicity in regard to organic pollutants, such as PCBs and PFCs. The results have inspired downward revisions of methylmercury exposure limits internationally. Other recent studies have targeted age-related functional deficits and degenerative diseases, such as Parkinson’s disease, cardiovascular disease, and type 2 diabetes in regard to life-time exposure to methylmercury, arsenic, persistent lipophilic contaminants, and perfluorinated compounds. Other efforts relate to biomarker development and validation, endocrine disruption caused by organochlorine substances. adverse effects of fluoride exposure, and the neurotoxicity of lead. Dr. Grandjean has also published on research ethics, genetic susceptibility, the setting of exposure limits, and the impact of the precautionary principle on prevention and research.

Recent News

Consensus on early origins (2012)

New Web Site: Chemical Brain Drain

New Book: Only One Chance

Publications

(Selected articles from 2011-2014)

Grandjean P, Ozonoff D. Transparency and translation of science in a modern world. Environ Health 2013; 12: 70.

Balbus JM, Barouki R, Birnbaum LS, Etzel RA, Gluckman PD, Grandjean P, Hancock C, Hanson MA, Heindel JJ, Hoffman K, Jensen GK, Keeling A, Neira M, Rabadán-Diehl C, Ralston J, Tang KC. Early-life prevention of non-communicable diseases (Comment). Lancet 2013; 381: 3-4.

Bellanger M, …(25 co-authors)…, and Grandjean P. Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention. Environ Health 2013; 12: 3.

Budtz-Jørgensen E, Bellinger D, Lanphear B, Grandjean P, International Pooled Lead Study Investigators. An international pooled analysis for obtaining a Benchmark dose for environmental lead exposure in children. Risk Anal 2013; 33: 450-61.

Grandjean P, Andersen EW, Budtz-Jørgensen E, Nielsen F, Mølbak K, Weihe P, Heilmann C. Decreased serum vaccine antibody concentrations in children exposed to perfluorinated compounds. JAMA 2012; 307: 391-7.

Wohlfahrt-Veje C, Andersen HR, Jensen TK, Grandjean P, Skakkebaek NE, Main KM. Smaller genitals at school age in boys whose mothers were exposed to non-persistent pesticides in early pregnancy. Int J Androl 2012; 35: 265-72.

Grandjean P, Grønlund C, Kjær IM, Jensen TK, Sørensen N, Andersson AM, Juul A, Skakkebæk NE, Budtz-Jørgensen E, Weihe P. Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls. Reprod Toxicol 2012; 34: 498-503.

Færch K, Højlund K, Vind BF, Vaag A, Dalgård C, Nielsen F, Grandjean P. Increased serum concentrations of persistent organic pollutants among prediabetic individuals: potential role of altered substrate oxidation patterns. J Clin Endocrinol Metab 2012; 97: E1705-13.

Choi AL, Sun G, Zhang Y, Grandjean P. Developmental fluoride neurotoxicity: A systematic review and meta-analysis. Environ Health Perspect 2012; 120: 1362-8.

Grandjean P, Eriksen ML, Ellegaard O, Wallin JA. The Matthew effect in environmental science publication: A bibliometric analysis of chemical substances in journal articles. Environ Health 2011; 10: 96.