MIPS Faculty

John Godleski

Associate Professor in the Department of Environmental Health
Department of Environmental Health

Building II
2nd Floor
655 Huntington Avenue
Boston MA 02115
phone: 617-432-1252
fax: 617-432-4528
Email: jgodlesk@hsph.harvard.edu
Other Affiliations:

    Associate Professor of Pathology, HMS

Education

    M.D., 1969, University of Pittsburgh

Research Interests:

    Dr. Godleski's research focuses upon the pulmonary and systemic responses to inhaled ambient air particles. His studies use cardiac and pulmonary mechanical measurements as well as cell and molecular biologic approaches with inhalation exposure to concentrated ambient air particles. The overall hypothesis is being tested in his laboratory is: Ambient urban air particles are complex mixtures with intrinsic toxicity; particulate exposure results in stimulation of lung receptors, release of reactive oxygen species, and induction of pro-inflammatory mediators that lead to local and systemic effects especially on the cardiovascular system, which ultimately account for epidemiologic associations between adverse health effects and particulate air pollution.

Publications:

    Wellenius GA, Saldiva PHN, Batalha JRF, Krishna Murthy GG, Coull BA, Verrier RL, Godleski JJ. Electrocardiographic Changes During Exposure to Residual Oil Fly Ash (ROFA) Particles in a Rat Model of Myocardial Infarction. Toxicol Sci. 2002, 66:327-335.

    Saldiva PHN, Clarke RW, Coull BA, Stearns R, Lawrence J, Koutrakis P, Suh H, Tsuda A, Godleski JJ. Acute Pulmonary Inflammation Induced by Concentrated Ambient Air Particles is Related to Particle Composition. Amer J Respir Crit Care Med. 2002, 165:1610-1617.

    Batalha JRF, Saldiva PHN, Clarke RW, Coull BA, Stearns RC, Lawrence J, Krishna Murthy GG, Koutrakis P, Godleski JJ. Concentrated Ambient Air Particles Induce Vasoconstriction of Small Pulmonary Arteries in Rats. Env. Health Perspectives. 2002; 110:1191-1197.

    Godleski JJ, Clarke RW, Coull BA, Saldiva PHN, Jiang NF, Lawrence J, and Koutrakis, P. Composition of Inhaled Urban Air Particles determines Acute Pulmonary Responses. Ann Occupational Hygiene. 2002; 46 (Supplement 1) 419-424.

    Wellenius GA, Coull BA, Godleski JJ, Koutrakis P, Okabe K, Savage ST, Lawrence JE, Krishna Murthy GG, Verrier RL. Inhalation of Concentrated Ambient Air Particles Exacerbates Myocardial Ischemia in Conscious Dogs. Env Health Perspectives. 2003; 111:402-408.

    Rhoden CR, Lawrence J, Godleski JJ, Gonzalez-Flecha B. N-acetylcysteine prevents lung inflammation after short-term inhalation exposure to concentrated ambient particles. Toxicologic Sciences. 2004: 79: 296-303.

    Wellenius GA, Batalha JRF, Diaz EA, Lawrence J, Coull BA, Katz T, Verrier RL, Godleski JJ. Cardiac effects of carbon monoxide and ambient particles in a rat model of myocardial infarction. Toxicologic Sciences. 2004: 80: 367-376.

    Pope CA, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, and Godleski JJ. Cardiovascular Mortality and Long-term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease. Circulation. 2004: 109:71-77.

    Godleski JJ. Role of asbestos in the etiology of malignant pleural mesothelioma. Chest Surgery Clinics of North America. 2004: 14: 479-487.

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