MIPS Research Scientists
Srboljub Mijailovich
Senior Research Scientist
Environmental Health
Physiology Program
Building I, Room 1306B
665 Huntington Avenue 02115
Education:
BSME, 1975, and MSME, 1982, University of Belgrade;
Ph.D., 1991, Massachusetts Institute of Technology (MIT)
Research
My current research focuses on the development of quantitative approaches to study biological systems at multiple levels of organization (i.e. multiscale modeling). In particular I am interested in developing a theoretical framework that will advance our understanding of how cellular and subcellular phenomena integrate to impact structure-function and dynamic relations of whole physiological systems, based on the kinetics of underlying molecular processes. Our laboratory, established in fall 2003, focuses on the interplay between mechanical forces, cell biology, and integrated organ physiology. The central issues are: (1) how a cell actively develops mechanical forces, and how these forces affect chemical transitions (for example in the actomyosin ATPase cycle); (2) how a cell senses and responds to mechanical forces; and (3) how changes in protein-protein interactions of the cytoskeletal elements and accessory proteins inside the cell can affect cell or organ properties and their function. We bring to this research area an interdisciplinary approach that spans engineering science, computational science, biology, biochemistry, and biophysics. We combine molecular, cellular, and whole organ approaches in order to understand cell and tissue biology, muscle physiology, and whole organ physiology. Pulmonary physiology and smooth muscle biology remain the core of our research experience, however, the interdisciplinary approach described in a recently awarded grant, can be expanded to the studies of the cardiovascular system and musculoskeletal disorders. Principal topics of our research include: (1) Quantitative System Analysis of Muscle Mechanics and Metabolism; (2) In Vitro Test of a Critical Phenomenon Causing Airway Closure in Normals and Asthmatics; (3) "Virtual Smooth Muscle" Project; and (4) the Development of a "Virtual Lung".
Publications
S.M. Mijailovich, J.P. Butler, and J.J. Fredberg, "Perturbed Equilibria of Myosin Binding Airway Smooth Muscle: Bond-Length Distributions, Mechanics and ATP Metabolism", Biophys. J. 79, 2667-2681, 2000.
S.M. Mijailovich, J.J. Fredberg, and J.P. Butler, "On the Theory of Muscle Contraction: Filament Extensibility and the Development of Isometric Force and Stiffness", Biophys. J. 71: 1475-1484, 1996.
S.M. Mijailovich, D. Stamenovic, and J.J. Fredberg, "Toward a Kinetic Theory of Connective Tissue Micro Mechanics", J. Appl. Physiol.: 74(2): 665-681,1993.
S.M. Mijailovich, D. Stamenovic, R. Brown, D. Leith, and J.J. Fredberg, "Dynamic Moduli of Rabbit Lung Parenchyma and Pigeon Ligamentum Propatagiale Undergoing Uniaxial Cyclic Loading", J. Appl. Physiol.: 75(2): 773-782, 1994.
S.M. Mijailovich, M. Kojic, M. Zivkovic, B. Fabry, and J. Fredberg, "A finite elment model of cell deformation during magnetic bead twisting", J. Appl. Physiol., Vol. 93, pp. 1429-1436, 2002.
S.M. Mijailovich, S. Treppo, and J.G. Venegas, "Effects of Lung Motion and Tracer Kinetics Corrections on PET Imaging of Pulmonary Function", J. Appl. Physiol. 82(4): 1154-1162, 1997.
J.J. Fredberg, D.S. Inouye, S.M. Mijailovich, and J.P. Butler, "Perturbed Equilibrium of Myosin Binding in Bovine Airway Smooth Muscle and its Implications on Bronchospasm", Am. J. Respir. Crit. Care Med. 159: 959-967, 1999.
N. Wang, K. Naruse, D. Stamenovic, J.J. Fredberg, S.M. Mijailovich, T. Polte, and E. Ingber, "Complex Mechanical Behavior in Living Cells", Proc. Natl. Acad. Sci. 98: 7765-7770, 2001
A. Tsuda, B.K. Stringer, S.M. Mijailovich, R.A. Rogers, K. Hamada, and M.L. Gray, "Alveolar Cell Stretching in the Presence of Fibrous Particles Induces IL-8 Responses", Am. J. Respir. Cell Molec. Biol. 21(4): 455-462, 1999.
N. Wang, I.M. Tolic-N?rrelykke, J. Chen, S.M. Mijailovich, J.P. Butler, J.J. Fredberg, and D. Stamenovic, "Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells", Am. J. Physiol. Cell Physiol. 282(3): C606-16, 2002.
D. Stamenovic, S.M. Mijailovich, I.M. Tolic-N?rrelykke, J. Chen, and N. Wang, "Cell prestress. II. Contribution of microtubules", Am. J. Physiol. Cell Physiol. 282(3): C617-24, 2002.
International Research Projects
Quantitative Bioengineering Analysis of Muscle Mechanics and Metabolism (UK, Australia)
Website
Computational Mechanobiology Lab Web Site
BSME, 1975, and MSME, 1982, University of Belgrade;
Ph.D., 1991, Massachusetts Institute of Technology (MIT)
Research
My current research focuses on the development of quantitative approaches to study biological systems at multiple levels of organization (i.e. multiscale modeling). In particular I am interested in developing a theoretical framework that will advance our understanding of how cellular and subcellular phenomena integrate to impact structure-function and dynamic relations of whole physiological systems, based on the kinetics of underlying molecular processes. Our laboratory, established in fall 2003, focuses on the interplay between mechanical forces, cell biology, and integrated organ physiology. The central issues are: (1) how a cell actively develops mechanical forces, and how these forces affect chemical transitions (for example in the actomyosin ATPase cycle); (2) how a cell senses and responds to mechanical forces; and (3) how changes in protein-protein interactions of the cytoskeletal elements and accessory proteins inside the cell can affect cell or organ properties and their function. We bring to this research area an interdisciplinary approach that spans engineering science, computational science, biology, biochemistry, and biophysics. We combine molecular, cellular, and whole organ approaches in order to understand cell and tissue biology, muscle physiology, and whole organ physiology. Pulmonary physiology and smooth muscle biology remain the core of our research experience, however, the interdisciplinary approach described in a recently awarded grant, can be expanded to the studies of the cardiovascular system and musculoskeletal disorders. Principal topics of our research include: (1) Quantitative System Analysis of Muscle Mechanics and Metabolism; (2) In Vitro Test of a Critical Phenomenon Causing Airway Closure in Normals and Asthmatics; (3) "Virtual Smooth Muscle" Project; and (4) the Development of a "Virtual Lung".
Publications
S.M. Mijailovich, J.P. Butler, and J.J. Fredberg, "Perturbed Equilibria of Myosin Binding Airway Smooth Muscle: Bond-Length Distributions, Mechanics and ATP Metabolism", Biophys. J. 79, 2667-2681, 2000.
S.M. Mijailovich, J.J. Fredberg, and J.P. Butler, "On the Theory of Muscle Contraction: Filament Extensibility and the Development of Isometric Force and Stiffness", Biophys. J. 71: 1475-1484, 1996.
S.M. Mijailovich, D. Stamenovic, and J.J. Fredberg, "Toward a Kinetic Theory of Connective Tissue Micro Mechanics", J. Appl. Physiol.: 74(2): 665-681,1993.
S.M. Mijailovich, D. Stamenovic, R. Brown, D. Leith, and J.J. Fredberg, "Dynamic Moduli of Rabbit Lung Parenchyma and Pigeon Ligamentum Propatagiale Undergoing Uniaxial Cyclic Loading", J. Appl. Physiol.: 75(2): 773-782, 1994.
S.M. Mijailovich, M. Kojic, M. Zivkovic, B. Fabry, and J. Fredberg, "A finite elment model of cell deformation during magnetic bead twisting", J. Appl. Physiol., Vol. 93, pp. 1429-1436, 2002.
S.M. Mijailovich, S. Treppo, and J.G. Venegas, "Effects of Lung Motion and Tracer Kinetics Corrections on PET Imaging of Pulmonary Function", J. Appl. Physiol. 82(4): 1154-1162, 1997.
J.J. Fredberg, D.S. Inouye, S.M. Mijailovich, and J.P. Butler, "Perturbed Equilibrium of Myosin Binding in Bovine Airway Smooth Muscle and its Implications on Bronchospasm", Am. J. Respir. Crit. Care Med. 159: 959-967, 1999.
N. Wang, K. Naruse, D. Stamenovic, J.J. Fredberg, S.M. Mijailovich, T. Polte, and E. Ingber, "Complex Mechanical Behavior in Living Cells", Proc. Natl. Acad. Sci. 98: 7765-7770, 2001
A. Tsuda, B.K. Stringer, S.M. Mijailovich, R.A. Rogers, K. Hamada, and M.L. Gray, "Alveolar Cell Stretching in the Presence of Fibrous Particles Induces IL-8 Responses", Am. J. Respir. Cell Molec. Biol. 21(4): 455-462, 1999.
N. Wang, I.M. Tolic-N?rrelykke, J. Chen, S.M. Mijailovich, J.P. Butler, J.J. Fredberg, and D. Stamenovic, "Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells", Am. J. Physiol. Cell Physiol. 282(3): C606-16, 2002.
D. Stamenovic, S.M. Mijailovich, I.M. Tolic-N?rrelykke, J. Chen, and N. Wang, "Cell prestress. II. Contribution of microtubules", Am. J. Physiol. Cell Physiol. 282(3): C617-24, 2002.
International Research Projects
Quantitative Bioengineering Analysis of Muscle Mechanics and Metabolism (UK, Australia)
Website
Computational Mechanobiology Lab Web Site
