PQG Seminar Series

The PQG will host another monthly seminar series for the 2014-2015 school year. Please see the full list of dates and speakers below, as they continue to be updated.

The goal of the PQG Seminar Series is to encourage the exchanging of ideas, promote interaction, collaboration, and research in quantitative genomics. It also aims to promote the mission of the PQG which is to improve health through an interdisciplinary study of genetics, behavior, environment and medicine. The seminar series looks to include the development and application of quantitative methods, especially for high dimensional data, as well as a focus on the training of quantitative genomic scientists.

Please direct any logistical questions to Shaina Andelman at sandelma@hsph.harvard.edu

Upcoming Seminar


Tuesday, October 14, 2014
12:30-2:00 PM
Kresge G2

a pizza lunch will be provided

Hongzhe Li
Professor
Departments of Biostatistics & Epidemiology
University of Pennsylvania - Perelman School of Medicine

“Microbiome, Metagenomics and High-Dimensional Compositional Data Analysis”

Next-generation sequencing technologies allow 16S ribosomal RNA gene surveys or whole metagenome shotgun sequencing in order to characterize taxonomic and functional compositions of gut microbiomes. The outputs from such studies are short sequence reads derived from a mixture of genomes of different species in a given microbial community. We first present a brief overview of the statistical methods we used for 16S rRNA data analysis. We then introduce a multi-sample model-based method to quantify the bacterial compositions based on shotgun metagenomics data using species-specific marker genes. The resulting data are high-dimensional compositional data, which complicate many of the downstream analyses. We introduce the GLMs with linear constraint on regression parameters in order to identify the bacterial taxa that are associated clinical outcomes and a composition-adjusted thresholding procedure to estimate correlation network from compositional data. We demonstrate the methods using two on-going gut microbiome studies at the University of Pennsylvania.

2014-2015 Seminar Schedule


  • Tuesday, September 16, 2014
    12:30-2:00 PM
    Kresge G2
    Soumya Raychaudhuri, Harvard Medical School
  • Tuesday, October 14, 2014
    12:30-2:00 PM
    Kresge G2
    Hongzhe Li, University of Pennsylvania


  • Tuesday, November 4, 2014
    12:30-2:00 PM
    Kresge G2
    Molly Przeworski, Columbia University

  • Tuesday, December 9, 2014
    12:30-2:00 PM
    Kresge G2
    Brian Browning, University of Washington

  • Tuesday, January 27, 2015
    12:30-2:00 PM
    Kresge G2
    Christopher Amos, Dartmouth Medical School

  • Tuesday, February 10, 2015
    12:30-2:00 PM
    Kresge G2
    Daniel MacArthur, Massachusetts General Hospital

  • WEDNESDAY, March 11, 2015
    12:30-1:30 PM
    FXB G13

    Gad Getz, The Broad Institute

  • Tuesday, March 31, 2015
    12:30-2:00 PM
    FXB G12
    David Altshuler, The Broad Institute

  • Tuesday, April 14, 2015
    12:30-2:00 PM
    FXB G12
    Hua Tang, Stanford University

  • Tuesday, May 5, 2015
    12:30-2:00 PM
    FXB G12
    Steve Horvath, UCLA




Seminar Archive