PQG Seminar Series

The PQG will host another monthly seminar series for the 2014-2015 school year. Please see the full list of dates and speakers below, as they continue to be updated.

The goal of the PQG Seminar Series is to encourage the exchanging of ideas, promote interaction, collaboration, and research in quantitative genomics. It also aims to promote the mission of the PQG which is to improve health through an interdisciplinary study of genetics, behavior, environment and medicine. The seminar series looks to include the development and application of quantitative methods, especially for high dimensional data, as well as a focus on the training of quantitative genomic scientists.

Please direct any logistical questions to Shaina Andelman at sandelma@hsph.harvard.edu

Upcoming Seminar


Tuesday, May 5, 2015
12:30-2:00 PM
FXB G12

a pizza lunch will be provided

Steve Horvath
Professor, Human Genetics & Biostatistics
University of California, Los Angeles

The Epigenetic Clock and Biological Age

I recently developed a DNA methylation based biomarker of aging known as the "epigenetic clock", which can be used to measure the DNA methylation (DNAm) age of any human (or chimpanzee) tissue, cell type, or fluid that contains DNA (with the exception of sperm). DNA methylation age of blood has been shown to predict all-cause mortality in later life, even after adjusting for known risk factors, which suggests that it relates to the biological aging process. Similarly, markers of physical and mental fitness are also found to be associated with the epigenetic clock (lower abilities associated with age acceleration). These results suggest that we may be close to achieving a long standing milestone in aging research: the development of an accurate measure of tissue age or even biological age. I will present several applications of this measure of tissue age, e.g. obesity and trisomy 21.

References:
1) Horvath S (2013) DNA methylation age of human tissues and cell types. Genome Biology.2013, 14:R115. DOI: 10.1186/10.1186/gb-2013-14-10-r115 PMID 24138928
2) Marioni R, Shah S, McRae A, Chen B, Colicino E, Harris S, Gibson J, Henders A, Redmond P, Cox S, Pattie A, Corley J, Murphy L, Martin N, Montgomery G, Feinberg A, Fallin M, Multhaup M, Jaffe A, Joehanes R, Schwartz J, Just A, Lunetta K, Murabito JM, Starr J, Horvath S, Baccarelli A, Levy D, Visscher P, Wray N, Deary I (2015) DNA methylation age of blood predicts all-cause mortality in later life. Genome Biology 16:25 doi:10.1186/s13059-015-0584-6
3) Horvath S, Erhart W, Brosch M, Ammerpohl O, von Schoenfels W, Ahrens M, Heits N, Bell JT, Tsai PC, Spector TD, Deloukas P, Siebert R, Sipos B, Becker T, Roecken C, Schafmayer C, Hampe J (2014) Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci U S A [6]. pii: 201412759. doi: 10.1073/pnas.1412759111 PMID 25313081
4 Horvath S, Garagnani P, Bacalini MG, Pirazzini C, Salvioli S, Gentilini D, DiBlasio AM, Giuliani C, Tung S, Vinters HV, Franceschi C (2015) Accelerated Epigenetic Aging in Down Syndrome. Aging Cell. 9 FEB 2015 DOI: 10.1111/acel.12325 PMID: 25678027



2014-2015 Seminar Schedule


  • Tuesday, September 16, 2014
    12:30-2:00 PM
    Kresge G2
    Soumya Raychaudhuri, Harvard Medical School
  • Tuesday, October 14, 2014
    12:30-2:00 PM
    Kresge G2
    Hongzhe Li, University of Pennsylvania

  • Tuesday, November 4, 2014
    12:30-2:00 PM
    Kresge G2
    Molly Przeworski, Columbia University

  • Tuesday, December 9, 2014
    12:30-2:00 PM
    Kresge G2
    Brian Browning, University of Washington

  • Tuesday, April 14, 2015
    12:30-2:00 PM
    FXB G12
    Hua Tang, Stanford University

  • Tuesday, May 5, 2015
    12:30-2:00 PM
    FXB G12
    Steve Horvath, UCLA

  • FRIDAY, May 15, 2015
    12:30-2:00 PM
    KRESGE G2
    Christopher Amos, Dartmouth Medical School




Seminar Archive