Short Courses and Tutorials


Short Course For Analyzing Quantitative 'Omic Data

The PQG will host another monthly short course series for the 2013-2014 school year. Please see the full list of dates and speakers below, as they continue to be updated.

The PQG offers the short course series on statistical and computational methods for analyzing genomic and 'omic data, genomic databases and resources, and data processing and analysis software, throughout the school year.

Organizer: Han Chen

Please direct any logistical questions to Shaina Andelman


Upcoming Short Course



Tuesday, March 10, 2015
12:30-2:00 PM
Building 2, Room 426 - Biostatistics Conference Room
a pizza lunch will be provided

Edoardo Airoldi
Associate Professor of Statistics
Director of Graduate Studies
Department of Statistics
Harvard University


Valid statistical analyses and reproducible science in the era of high-throughput biology

High-throughput technology (eg, sequencing, mass spec) allows us to quantify biological mechanisms at a resolution that array technology and small scale experiments cannot. In the next 5-10 years, a substantial portion of biological research is expected to leverage some of these technologies. This flexibility comes with a price, however. Modern high-throughput instrumentation relies on built-in data collection protocols that are often biased. For instance, a mass spec selects the most abundant ions, at an early stage of the measurement process, for further analysis. The major unexpected consequence of such protocols is that they carry information about those quantities we are interested in estimating, e.g., absolute protein abundance, in the mass spec example. Scientists that do not account for this information in the analysis, whether by counting or estimation using a statistical model, will likely base their scientific conclusions on misleading numbers, even in simple experimental conditions. This statistical issue is poorly understood by practitioners and amateur statisticians alike. It is arguably the main challenge we need to tackle to produce valid scientific conclusions in the era of high-throughput technology. I'll provide two illustrations in mass spectrometry and genomics.

 

2014-2015 Short Courses


  • Tuesday, September 23, 2014
    12:30-2:00 PM
    Building 2, Room 426 - Biostatistics Conference Room
    Chunyu Liu, Ph.D., NHLBI’s Framingham Heart Study

  • Tuesday, November 18, 2014
    12:30-2:00 PM
    Building 2, Room 426 - Biostatistics Conference Room
    Allan Just, Harvard School of Public Health

  • Tuesday, December 16, 2014
    12:30-2:00 PM
    Building 2, Room 426 - Biostatistics Conference Room
    Honghuang Lin, Boston University School of Medicine

  • Tuesday, February 17, 2015
    12:30-2:00 PM
    Building 2, Room 426 - Biostatistics Conference Room
    Andrea Baccarelli, Harvard School of Public Health

  • Tuesday, March 10, 2015
    12:30-2:00 PM
    Building 2, Room 426 - Biostatistics Conference Room
    Edoardo Airoldi, Harvard University

  • Tuesday, April 28, 2015
    12:30-2:00 PM
    Building 2, Room 426 - Biostatistics Conference Room
    Huanyu Zhou, Pfizer

 



Short Course and Tutorial Archive