Symposium on Advances in Endometrial Cancer Epidemiology and Biology at HSPH
On March 17-18th Immaculata De Vivo hosted the Advances in Endometrial Cancer Epidemiology and Biology Symposium. The overall goal of the symposium was to identify priorities for future research that will have a strong impact on risk of and outcomes from endometrial cancer. Dr. De Vivo gave the opening and closing remarks, and also gave a presentation of her work on GWAS and XWAS results. Other notable speakers included Drs. David Hunter, Peter Kraft, and Jennifer Prescott, all members of PGSG. Many other researchers from multiple disciplines (epidemiologists, clinicians, and medical doctors) traveled from all over the country to attend the symposium. Karen Lu from MD Anderson Cancer Center, Sara Olson of Memorial Sloan-Kettering Cancer Center, and Wendy Setiawan from the University of Southern California were all co-organizers. The event was a huge success, and there is already talk of planning the next one!
PGSG Deputy Director to Co-Direct AACR workshop
For the second year in a row, Peter Kraft will be Co-Director of an exciting workshop this summer in Boston, MA. The AACR’s Integrative Molecular Epidemiology Workshop is designed to accelerate the training of the next generation of cancer researchers. The workshop is primarily targeted toward molecular epidemiologists, but will also be a valuable experience for geneticists, statisticians, bioinformaticians, molecular biologists, physician scientists and others who have done basic course work in epidemiology. As Co-Director and member of the planning committee, Dr. Kraft has been very closely involved in organizing this event; Dr. Lorelei Mucci, Associate Professor of Epidemiology at HSPH, is also a workshop faculty member and member of the planning committee. The workshop was a great success when it was first held last year, and the organizers are working hard to put together another exciting learning experience for attendees.
The workshop is from August 11-15, 2014, in Boston. Applications will be accepted until April 14th. For more details visit the event website.
Epi in Space
An exciting new study led by NASA’s Human Research Program and the National Space Biomedical Research Institute will fund several investigations into the molecular, physiological and psychological effects of spaceflight in an effort to better understand the health impacts of human space exploration. Identical twins Scott and Mark Kelly, both veteran astronauts, will be the focus of this study. Scott Kelly will live aboard the International Space Station for one year while his twin brother, Mark Kelly, remains on Earth as a control. PI Immaculata De Vivo and lab manager Pati Soule are collaborating with researchers at Colorado State University to analyze the effect of spaceflight on telomeres. Telomeres are stretches of DNA found at the end of chromosomes; they shorten over time as cells divide and are associated with aging, cancer, and a higher risk of death. The project, “Differential effects on telomeres and telomerase in twin astronauts associated with spaceflight” will study astronaut Scott Kelly’s telomeres during his year in space and compare them to his twin. The researchers are excited to be a part of this first-of-its-kind investigation.
PGSG is the new PMAGE
The Program in Molecular and Genetic Epidemiology has changed its name to the Program in Genetic Epidemiology and Statistical Genetics (PGSG). The new name reflects the Program’s expanded interest in statistical methods for genetic epidemiology, ranging from new methods to estimate the genetic contribution to disease risk (here, here, and here), integrate germline genetic variation, gene expression and methylation (here and here), and identify and interpret gene-environment interactions (here and here).
Program faculty, fellows and students continue to pursue research to understand the molecular mechanisms underlying complex diseases, using a wide range of biomarkers (here and here).
Dr. Jiali Han has accepted an exciting new opportunity- effective September 1st, he is Professor and Department Chair of Epidemiology at the Richard M. Fairbanks School of Public Health, Efroymson Professor of Oncology, Simon Cancer Center, at Indiana University at Indianapolis. Dr. Han will also remain affiliated with HSPH as an adjunct professor in the Department of Epidemiology.
Alexis Carere has received a Doctoral Foreign Study Award from the Canadian Institutes of Health Research. Dr. Peter Kraft and Dr. Robert Green co-supervise her project, titled, “A prospective cohort of direct-to-consumer genetic testing customers: Consumer motivations, behavioral responses, and their impact on the health care system.”
Recent PMAGE graduate Linda Hiraki received postdoctoral fellowship awards from the Canadian Institutes of Health Research and STAGE (Strategic Training for Advanced Genetic Epidemiology). She will be working with Dr. Andrew Paterson at the Hospital for Sick Children and the University of Toronto.
Liming Liang was lead author on a Genome Research paper describing new methods for analyzing expression quantitative trait loci (eQTLs) and a new freely available data base containing over 14,000 high-confidence eQTLs. This database can help define the function of disease-associated variants.
Rulla Tamimi published several papers on the links between obesity, mammographic density, and molecularly-defined breast cancer subtypes.
Hugo Aschard, a Research Associate in the PGSG, published a paper on non-parametric methods for genetic association in Genetic Epidemiology.
Alkes Price is senior author of papers published or in press at Nature Genetics, Genome Research, Bioinformatics, and two papers in PLoS Genetics.
Rulla Tamimi is Co-PI on a new grant funded by Susan G. Komen for the Cure. The study, “Environmental exposures, early proliferative changes and breast cancer risk,” will evaluate if environmental exposures and geographic variation over the life course are related to mammographic density, proliferative BBD and breast cancer risk, independent of individual level risk factors. In addition, it also examines the associations of air pollution and UV-B with gene expression in normal (benign) breast tissue. Dr. Tamimi will be working with Co-PI Francince Laden, Associate Professor of Epidemiology and Environmental Health at HSPH.
Postdoctoral Fellow Bjarni Vilhjalmsson received a DFF-Individual postdoctoral grant to support his research.
Alkes Price and Peter Kraft, in collaboration with Ben Neale and Shamil Sunyaev of the Broad Institute, received an R01 to develop statistical methods for studies of rare variants.
Jennifer Prescott, who has worked with Dr. De Vivo for several years as a research fellow and now an instructor, was awarded a new grant from the Harvard Transdisciplinary Research on Energetics and Cancer (TREC) Center. The title of the project is “Influence of a family history of Type 2 Diabetes on colorectal cancer risk and mortality, and on biomarkers of glycemic control, plasma lipids, and inflammatory biomarkers.” The researchers hypothesize that increased insulin signaling increases the risk of colorectal cancer, based on previous studies that have shown healthy first-degree relatives of type 2 diabetics to have reduced insulin secretion due to impaired beta-cell function. The project will explore whether a family history of type 2 diabetes is associated with reduced risk of colorectal cancer incidence and mortality, and/or alters biomarkers associated with insulin action in the NHS and HPFS cohorts. Dr. Prescott will also explore whether a genetic risk score for type 2 diabetes is associated with colorectal cancer risk.
Postdoctoral fellow Amit Joshi also received grant funding from the TREC Center. Dr. Joshi’s research project is entitled “Effect modification of association of GWAS-identified susceptibility SNPs for body mass index with post-menopausal breast cancer risk by physical activity.” He will use data from the Nurses’ Health Study, which is one of the largest and longest running investigations of factors that influence women’s health.
Dr. Hugues Aschard, postdoctoral fellow under Dr. Kraft, was recently awarded grant 1R03HG006720-01A1, “Relaxing genetic models to identify genetic variants involved in gene-gene and gene-environment interactions.” Dr. Aschard and his colleagues developed a non-parametric test of association that compares phenotypic distribution by genotypic classes, which aims to identify quantitative trait loci involved in interactions. The aims of his grant are to identify potential technical improvements of the proposed method and to conduct real data application to identify genetic variants that have been missed by standard genome-wide association screening.