COURSE INFORMATION
Genetics and Complex Diseases

GCD211 Metabolic Processes Underlying Complex Diseases
Fall
Dr. B Manning, Dr. C. H. Lee
5 Credits
Lectures. Two 2-hour sessions each week.

This course will cover key cellular metabolic processes and discuss how deregulation of these processes leads to complex human diseases, such as cancer, insulin resistance, dyslipidemia and atherosclerosis. An emphasis will be placed on how cellular signaling pathways impinge on cell metabolism under both normal and disease states. The course will be divided into two sections: Part 1: tumor cell metabolism and Part 2: metabolic diseases. The class will meet twice a week. For the most part, lectures will be given on Mondays and critical discussion of classical and current primary literature will take place on Fridays. Part 1 will focus on cellular metabolic pathways and signaling networks in normal and tumor cells. Part 2 will emphasize organismal metabolism and inter-tissue communication in metabolic homeostasis at physiological and pathological states. This course is limited to 15 doctoral students from the BPH program or other Harvard Integrated Life Sciences (HILS) programs. A firm knowledge of basic biochemistry is a prerequisite.

Course Objectives
At the end of the course, the student will be able to
Part 1:
- describe how cellular metabolism differs between normal and cancer cells
- describe the genetic events underlying these changes.
- distinguish potential areas of therapeutic intervention.

Part 2:
- describe energy substrate metabolism in major metabolic tissues
- summarize the pathophysiology of metabolic diseases
- critically analyze current research in metabolic control

Course Note: Ordinal grading option only.
Course Evaluations

GCD300 Independent Study/Tutorial
Fall 1
Department Members
Time and credit to be arranged

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.
Course Evaluations

GCD300 Independent Study/Tutorial
Fall
Department Members
Time and credit to be arranged

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.
Course Evaluations

GCD300 Independent Study/Tutorial
Fall 2
Department Members
Time and credit to be arranged

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.
Course Evaluations

GCD300 Independent Study/Tutorial
Spring 1
Department Members
Time and credit to be arranged

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.
Course Evaluations

GCD300 Independent Study/Tutorial
Spring
Department Members
Time and credit to be arranged

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.
Course Evaluations

GCD300 Independent Study/Tutorial
Spring 2
Department Members
Time and credit to be arranged

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.
Course Evaluations

GCD300 Independent Study/Tutorial
WinterSession
Department Members
Time and credit to be arranged

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.
Course Evaluations

GCD350 Research
Fall 1
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

Course Evaluations

GCD350 Research
Fall
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

Course Evaluations

GCD350 Research
Fall 2
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

Course Evaluations

GCD350 Research
Spring 1
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

Course Evaluations

GCD350 Research
Spring
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

Course Evaluations

GCD350 Research
Spring 2
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

Course Evaluations

GCD350 Research
WinterSession
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

Course Evaluations

GCD400 Non-Resident Research
Fall 1
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/fail only; maximum of 20 credits, signature of instructor required.

Course Evaluations

GCD400 Non-Resident Research
Fall
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/fail only; maximum of 20 credits, signature of instructor required.

Course Evaluations

GCD400 Non-Resident Research
Fall 2
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/fail only; maximum of 20 credits, signature of instructor required.

Course Evaluations

GCD400 Non-Resident Research
Spring 1
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/fail only; maximum of 20 credits, signature of instructor required.

Course Evaluations

GCD400 Non-Resident Research
Spring
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/fail only; maximum of 20 credits, signature of instructor required.

Course Evaluations

GCD400 Non-Resident Research
Spring 2
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/fail only; maximum of 20 credits, signature of instructor required.

Course Evaluations

GCD400 Non-Resident Research
Spring 2
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/fail only; maximum of 20 credits, signature of instructor required.

Course Evaluations

GCD400 Non-Resident Research
WinterSession
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/fail only; maximum of 20 credits, signature of instructor required.

Course Evaluations

ID512 Molecular Basis of Nutritional and Metabolic Diseases
Spring
Department of Genetics and Complex Diseases and Department of Nutrition
Dr. G. Hotamisligil, Dr. C. H. Lee
2.5 credits
Seminars. One 2-hour session and one 1-hour seminar each week.

Students have an opportunity to review and analyze key papers that provide physiological and molecular evidence that bears on a topic of current interest in human nutrition and related disorders. Additionally, students learn skills necessary for critical thinking, and oral and written presentations.
Course Note: HSPH degree candidates only; signature of instructor required.


Course evaluations are an important method for feedback on the quality of course offerings. The submission of a course evaluation is a requirement for this course. Your grade for the course will be made available only after you have submitted responses to at least the first three questions of the on-line evaluation for this course.
Course Evaluations

ID518 Integrated Cancer Biology
WinterSession
Department of Environmental Health and Department of Genetics and Complex Diseases
Dr. H. Nelson, Dr. K. Kelsey
2.5 Credits
Course not offered 2006-2007. Will be offered in Spring, 2007-2008.
Case Studies. Four 2-hour sessions each week during WinterSession.

This course will use case-based and problem-based approaches to Cancer Biology. The course will meet four times per week and will involve a mix of case presentations/discussions, and problem-based classes with small group work followed by group presentations. Each case/problem will be chosen based on a unique exposure event; elements of exposure assessment, epidemiology, and molecular clinical biology will be presented. The end of each case presentation will be devoted to discussion of study design and how the integrated elements of the malignancy (i.e. exposure, molecular biology, and clinical presentation) should be considered and addressed. Problem-based sessions will include small group work and class presentations.
Course Note: GCD210 required. Enrollment limited, instructor's signature required; priority will be given to doctoral candidates. Minimum enrollment required. Course offered January 3 - 25, from 10 am to 12 pm, during WinterSession.


Course evaluations are an important method for feedback on the quality of course offerings. The submission of a course evaluation is a requirement for this course. Your grade for the course will be made available only after you have submitted responses to at least the first three questions of the on-line evaluation for this course.
Course Evaluations

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