Bioinformatics Forum
Tuesday, May 13, 2008
12:30-1:20pm
Kresge 502
(Pizza Lunch will be provided)
Robert C. Elston, PhD
Director, Division of Genetic and Molecular Epidemiology
Professor, Department of Epidemiology and Biostatistics
Case Western Reserve University (CWRU)
CWRU Dept. of Epi. & Biostat. Web site: http://epbiwww.case.edu/
Robert Elston's Web site: http://darwin.cwru.edu/rce/
"Using the Results of Genome Wide Association Studies to Form Predictive Genetic Tests"
Abstract
"Current extensive genetic research into common complex diseases, especially with the completion of genome-wide association studies, is bringing to light many novel genetic risk loci. These new discoveries, along with previously known genetic risk variants, offer an important opportunity to improve health care. We describe a method of quickly evaluating these new findings for potential clinical practice by designing a new predictive genetic test, estimating its classification accuracy, and determining the sample size required to verify this accuracy. The proposed predictive test is asymptotically more powerful than tests built on any other existing method and can be extended to scenarios where loci are linked or interact. We illustrate the approach or the case of Type 2 diabetes. We incorporate recently discovered risk factors into the proposed test and find a potentially better predictive genetic test. The area under the ROC curve (AUC) of the proposed test is estimated to be higher (AUC=0.671) than for the existing test (AUC=0.580)."
Speaker's Biography:
Robert C. Elston is Professor in the Department of Epidemiology and Biostatistics at Case Western Reserve University in Cleveland, Ohio and the Principle Investigator of a Human Genetic Analysis Resource grant from the National Center for Research Resources, which facilitates the detection, mapping and ultimate identification of genes that cause multifactorial diseases in man. He did his undergraduate work at Cambridge University in Natural Sciences and received his Ph.D. in Animal Breeding from Cornell University in Ithaca. Except for an interlude of two years from 1962 to 1964, during which time he was Senior Fellow in Biometric Medicine at the University of Aberdeen, Scotland, Dr. Elston was in the School of Public Health at the University of North Carolina, Chapel Hill, from 1959-1979, eventually becoming full Professor of Biostatistics and Genetics. From 1979 to 1995 he was Head of the Department of Biometry and Genetics at the Louisiana State Medical Center in New Orleans. Since 1995 he has been the Professor Director of the Division of Genetic and Molecular Epidemiology in the Department of Epidemiology and Biostatistics at Case Western Reserve University.
Past Forums:
Date:April 1, 2008
Speaker: Joshua LaBaer, PhD
Title:Functional Proteomics for Biomarker and Target Discovery
Date: March 18, 2008
Speaker: Collin M. Stultz, MD, PhD
Title: Identifying Long Range Correlations in Proteins Using a Combination of Statistical Models and Physical Energy Functions
Date: February 5, 2008
Speaker: Frederick Roth, PhD
Title: Systematic Analysis of Mouse Gene Function
Date: January 8, 2008
Speaker: Martin W. McIntosh, PhD
Title: Analysis Methods and Platform for Combining Tandem MS/MS and High Resolution LC-MS Data for Quantitative Proteomics
More past activities in archive.