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Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. IDENTIFICATION OF A LIPOKINE, A LIPID HORMONE LINKING ADIPOSE TISSUE TO SYSTEMIC METABOLISM. Cell, 2008, 134(6):933-44. Abstract | PDF
Furuhashi M, Fucho R, Gorgun CZ, Tuncman G, Cao H, Hotamisligil GS. ADIPOCYTE/MACROPHAGE FATTY ACID-BINDING PROTEINS CONTRIBUTE TO METABOLIC DETERIORATION THROUGH ACTIONS IN BOTH MACROPHAGES AND ADIPOCYTES IN MICE J Clin Invest, 2008, doi:10. 1172/JCI34750. Abstract | PDF
Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, Manning BD, Hotamisligil GS. LOSS OF THE TUBEROUS SCLEROSIS COMPLEX TUMOR SUPPRESSORS TRIGGERS THE UNFOLDED PROTEIN RESPONSE TO REGULATE INSULIN SIGNALING AND APOPTOSIS Molecular Cell, 2008, 29:541-551. Abstract | PDF
Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, MacRae FL, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. TREATMENT OF DIABETES AND ATHEROSCLEROSIS BY INHIBITING FATTY-ACID-BINDING PROTEIN aP2 Nature, 2007, 447:959-965. Abstract | PDF
Wellen K, Fucho R, Gregor M, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun C, Saatcioglu F, Hotamisligil GS. COORDINATED REGULATION OF NUTRIENT AND INFLAMMATORY RESPONSES BY STAMP2 IS ESSENTIAL FOR METABOLIC HOMEOSTASIS. Cell, 2007, 129(3):537-48. Abstract | PDF
Hotamisligil GS. INFLAMMATION AND METABOLIC DISORDERS. Nature, 2006, 444(7121):860-7. Abstract | PDF
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS. CHEMICAL CHAPERONES REDUCE ER STRESS AND RESTORE GLUCOSE HOMEOSTASIS IN A MOUSE MODEL OF TYPE 2 DIABETES. Science, 2006, 313(5790):1137-40. Abstract | PDF
Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil, GS. REGULATION OF METABOLIC RESPONSES BY ADIPOCYTE/MACROPHAGE FATTY ACID-BINDING PROTEINS IN LEPTIN-DEFICIENT MICE. Diabetes, 2006, 55(7):1915-22. Abstract | PDF
Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. FUNCTIONAL IN VIVO INTERACTIONS BETWEEN JNK1 AND JNK2 ISOFORMS IN OBESITY AND INSULIN RESISTANCE. Proc Natl Acad Sci USA, 2006, 103(28):10741-46. Abstract | PDF
Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A GENETIC VARIANT AT THE FATTY ACID BINDING PROTEIN AP2 LOCUS REDUCES THE RISK FOR HYPERTRIGLYCERIDEMIA, TYPE 2 DIABETES AND CARDIOVASCULAR DISEASE. Proc Natl Acad Sci USA, 2006, 103(18):6970-5. Abstract | PDF
Hotamisligil, GS. ROLE OF ENDOPLASMIC RETICULUM STRESS AND C-JUN NH2-TERMINAL KINASE PATHWAYS IN INFLAMMATION AND ORIGIN OF OBESITY AND DIABETES. Diabetes, 2005, 54:Suppl2:S73-78. Abstract | PDF
Tsai J, Tong Q, Tan G, Chang A, Orkin S, Hotamisligil, GS. THE TRANSCRIPTION FACTOR GATA2 REGULATES DIFFERENTIATION OF BROWN ADIPOCYTES EMBO Reports, 2005, 6(9):879-884. Abstract | PDF
Wellen KE, Hotamisligil, GS. INFLAMMATION, STRESS, AND DIABETES J Clin Invest, 2005, 115:1111-1119. Abstract | PDF
Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS. INTERACTION BETWEEN GATA AND C/EBP FAMILY OF TRANSCRIPTION FACTORS IS CRITICAL IN GATA-MEDIATED SUPRESSION OF ADIPOCYTE DIFFERENTIATION. Mol Cell Bio 2005, 25(2): 706-715. Abstract | PDF
Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil, GS. ADIPOCYTE/MACROPHAGE FATTY ACID BINDING PROTEINS CONTROL INTEGRATED METABOLIC RESPONSES IN OBESITY AND DIABETES. Cell Metabolism, 2005, 1:107-119. Abstract | PDF
Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. THE FATTY ACID BINDING PROTEIN, AP2, COORDINATES MACROPHAGE CHOLESTEROL TRAFFICKING AND INFLAMMATORY ACTIVITY. J Biol Chem, 2005, epublication. Abstract | PDF
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS. ENDOPLASMIC RETICULUM STRESS LINKS OBESITY, INSULIN ACTION AND TYPE 2 DIABITIES. Science, 2004, 306:457-61. Abstract | PDF
Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. COMBINED FATTY ACID-BINDING PROTEIN DEFICIENCY IMPROVES METABOLISM, REDUCES ATHEROSCLEROSIS, AND INCREASES SURVIVAL IN APOLIPOPROTEIN E-DEFICIENT MICE. Circulation, 2004, 110(11):1492-1498. Abstract | PDF
Makowski L and Hotamisligil GS. FATTY ACID BINDING PROTEINS-THE EVOLUTIONARY CROSSROADS OF INFLAMMATORY AND METABOLIC RESPONSES. J of Nutrition, 2004, 134(9):2464S-2468S. Abstract | PDF
Wellen KE, Uysal KT. Wiesbrock S. Yang Q, Chen H. Hotamisligil GS. INTERACTION OF TUMOR NECROSIS FACTOR-ALPHA- AND THIAZOLIDINEDIONE-REGULATED PATHWAYS IN OBESITY. Endocrinology. 2004, 145(5):2214-20. Abstract | PDF
Hotamisligil GS. INFLAMMATION, TUMOR NECROSIS FACTOR, AND INSULIN RESISTANCE. IN LEROITH, D, TAYLOR SI, OLEFSKY, JM, EDS. IN DIABITIES MELLITUS: A FUNDAMENTAL AND CLINICAL TEXT. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2003, Chapter 64:953-962. PDF
Tong, Q, Sankalé, J-L, Hadigan, CM, Tan, G, Rosenberg, ES, Kanki, PJ, Grinspoon, SK, Hotamisligil, GS. REGULATION OF ADIPONECTIN IN HUMAN IMMUNODEFICINCY VIRUS INFECTED PATIENTS: RELATIONSHIP TO BODY COMPOSITION AND METABOLIC INDICES. J Clin Endocrinol Metabol, 2003, 88:1559-1564. Abstract | PDF
Hotamisligil GS. THE IRRESISTIBLE BIOLOGY OF RESISTIN. Journal of Clinical Investigation, 2003, 111:173-174. PDF
Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Bruning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. ROLE OF THE FATTY ACID BINDING PROTEIN MAL1 IN OBESITY AND INSULIN RESISTANCE. Diabetes, 2003, 52: 300-307. Abstract | PDF
Xu, H, Uysal, KT, Becherer, D, Arner, P, Hotamisligil, GS. ALTERED TNF a PROCESSING IN ADIPOCYTES AND INCREASED EXPRESSION OF TRANSMEMBRANE TNF a IN OBESITY. Diabetes, 2002, 51:1876-1883. Abstract | PDF
Boord, JB, Maeda, K, Makowski, L, Babaev, VR, Fazio, S, Linton, MF, Hotamisligil, GS. ADIPOCYTE FATTY ACID BINDING PROTEIN, AP2, ALTERS LATER ATHEROSCLEROTIC LESION FORMATION IN SEVERE HYPERCHOLESTEROLEMIA. Art, Thro, Vasc Bio, 2002, 22:1686-1691. Abstract | PDF
Hirosumi, J, Tuncman, G, Chang, L, Gorgun, CZ, Uysal, KT, Maeda, K, Karin, M, Hotamisligil, GS. A CENTRAL ROLE FOR JNK IN OBESITY AND INSULIN RESISTANCE. Nature, 2002,420:333-336. Abstract | PDF
Xu H, Hotamisligil GS. SIGNALING PATHWAYS UTILIZED BY TUMOR NECROSIS FACTOR RECEPTOR 1 IN ADIPOCYTES TO SUPPRESS DIFFERENTIATION. FEBS Lett. 506(2):97-102, 2001. Abstract | PDF
Way JM. Gorgun CZ. Tong Q. Uysal KT. Brown KK. Harrington WW. Oliver WR Jr. Willson TM. Kliewer SA. Hotamisligil GS. ADIPOSE TISSUE RESISTIN EXPRESSION IS SEVERELY SUPPRESSED IN OBESITY AND STIMULATED BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AGONISTS. Journal of Biological Chemistry. 276(28):25651-3, 2001. Abstract | PDF
Makowski L. Boord JB. Maeda K. Babaev VR. Uysal KT. Morgan MA. Parker RA. Suttles J. Fazio S. Hotamisligil GS. Linton MF. LACK OF MACROPHAGE FATTY-ACID-BINDING PROTEIN AP2 PROTECTS MICE DEFICIENT IN APOLIPOPROTEIN E AGAINST ATHEROSCLEROSIS. Nature Medicine. 7(6):699-705, 2001. Abstract | PDF
Tong Q. Dalgin G. Xu H. Ting CN. Leiden JM. Hotamisligil GS. FUNCTION OF GATA TRANSCRIPTION FACTORS IN PREADIPOCYTE-ADIPOCYTE TRANSITION. Science. 290(5489):134-138, 2000. Abstract | PDF
Uysal KT. Scheja L.Wiesbrock SM. Bonner-Weir S. Hotamisligil GS. IMPROVED GLUCOSE AND LIPID METABOLISM IN GENETICALLY OBESE MICE LACKING AP2. Endocrinology. 141(9):3388-96, 2000. Abstract | PDF
Nisoli E. Briscini L. Giordano A. Tonello C. Wiesbrock SM. Uysal KT. Cinti S. Carruba MO. Hotamisligil GS. TUMOR NECROSIS FACTOR ALPHA MEDIATES APOPTOSIS OF BROWN ADIPOCYTES AND DEFECTIVE BROWN ADIPOCYTE FUNCTION IN OBESITY. Proceedings of the National Academy of Sciences of the United States of America. 97(14):8033-8, 2000. Abstract | PDF
Sethi JK. Xu H. Uysal KT. Wiesbrock SM. Scheja L. Hotamisligil GS. CHARACTERISATION OF RECEPTOR-SPECIFIC TNFa FUNCTIONS IN ADIPOCYTE CELL LINES LACKING TYPE 1 AND 2 TNF RECEPTORS. FEBS Letters. 469(1):77-82, 2000. Abstract | PDF
Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA and Hotamisligil GS. ALTERED INSULIN SECRETION ASSOCIATED WITH REDUCED LIPOLYTIC EFFICIENCY IN aP2-/- MICE. Diabetes, 1999 Oct; 48:1987-1994. Abstract | PDF
Xu H, Sethi JK, Uysal KT, Wiesbrock SM, Scheja L and Hotamisligil GS. THE TRANSMEMBRANE FORM OF TUMOR NECROSIS FACTOR ALPHA INHIBITS ADIPOGENESIS VIA TNFR1. J. Biol. Chem. 1999. 274(37):26287-26295. Abstract | PDF
Samad F, Uysal KT, Wiesbrock SM, Hotamisligil GS, and Loskutoff DJ. TUMOR NECROSIS FACTOR ALPHA: A KEY COMPONENT IN THE OBESITY-LINKED ELEVATION OF PLASMINOGEN ACTIVATOR INHIBITOR-1. Proceedings of The National Academy of Sciences 1999 ; 96:6902-6907. Abstract | PDF
Sethi JK and Hotamisligil GS THE ROLE OF TUMOR NECROSIS FACTOR ALPHA IN ADIPOSE METABOLISM. Seminars in Cell and Developmental Biology 1999 Apr ; 10(2):19-29. Abstract | PDF
Uysal KT, Wiesbrock SM, and Hotamisligil GS. FUNCTIONAL ANAYLSIS OF TNFa RECEPTORS IN TNFa-MEDIATED INSULIN RESISTANCE IN GENETIC OBESITY. Endocrinology 1998 Dec;139(12):4832-4838. Abstract | PDF
Kirchgessner T, Uysal KT, Wiesbrock SM, Marino MW and Hotamisligil GS. TUMOR NECROSIS FACTOR ALPHA CONTRIBUTES TO OBESITY-RELATED HYPERLEPTINEMIA BY REGULATING LEPTIN RELEASE FROM ADIPOCYTES. Journal of Clinical Investigation 1997 Dec 1; 100(11): 2777-2782. Abstract | PDF
Uysal KT, Wiesbrock SM, Marino MW and Hotamisligil GS. PROTECTION FROM OBESITY-INDUCED INSULIN RESISTANCE IN MICE LACKING TNFa FUNCTION. Nature. 1997 Oct 9; 389(6651): 610-614. Abstract | PDF