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John B. Little Center for Radiation Sciences and Environmental Health

JBL Symposium

12th Annual JBL Symposium October 23-24, 2009

               Twelfth Annual John B. Little Symposium

                "Cellular Reponses to Molecular Damage:                        Genetic Stability, Radioresistance and Aging"

Friday, 23 October 2009

1:00-1:10pm: Welcome and Introduction                                      John B. Little, Department of Genetics & Complex Diseases, Harvard School of Public Health

1:10–2:00 pm: JBL Award Lecture

Matthew Meselson, Thomas Dudley Cabot Professor of the Natural Sciences, Department of Molecular and Cellular Biology, Harvard University

"How does ionizing radiation kill cells: early clues from bystander effects"
 

2:00–5:30 pm: Session I
Discussion leader: Bruce Demple, Professor of Pharmacological Sciences, Stony Brook University Medical School

2:00–2:45 pm: Michael J. Daly, Professor of Pathology, Department of Pathology, Uniformed Service University of the Health Sciences
"Small molecule proteome-shields in Deinococcus radiodurans"

2:45–3:30 pm: Ursula Jakob, Associate Professor, Department of Molecular, Cellular, and Developmental Biology, University of Michigan
"Oxidative stress and redox regulation"

3:30–4:00 pm: Break

4:00–4:45 pm: Anindya Dutta, Harry F. Byrd Professor, Department of Biochemistry and Molecular Genetics, University of Virginia
"Mechanisms by which the human cell restricts DNA replication to once per cell cycle"

4:45–5:30 pm: Stephen P. Bell, Professor of Biology, Massachusetts Institute of Technology, Investigator, Howard Hughes Medical Institute
"Triggering replication initiation: a cascade of kinases at the origin"

5:30–7:00 pm: Reception in the Harvard School of Public Health Cafeteria

Saturday, October 24, 2009

8:00–9:00 am: Breakfast in the Harvard School of Public Health Cafeteria

9:00–12:25 pm: Session II
Discussion leader: Alan D’Andrea, Chief, Division of Radiation and Cancer Biology, Dana-Farber Cancer Institute, Fuller-American Cancer Society Professor, Department of Radiation Oncology, Harvard Medical School

9:00–9:05 am: Introduction

9:05–9:50 am: Junjie Chen, Professor, M.D. Anderson Cancer Center, Department of Experimental Radiation Oncology, University of Texas
"Chromatin structure and DNA damage response"
 
9:50–10:35 am: Penny Jeggo, Professor, Genome Damage and Stability Centre, University of Sussex
"ATM, higher order chromatin structure and DNA double strand break repair: how they link"
 

10:35–10:55 am: Break

10:55–11:40 am: Lee Zou, Assistant Professor of Pathology, Harvard Medical School / Massachusetts General Hospital Cancer Center
"Sensing and signaling DNA damage through the ATM and ATR checkpoints"
 
11:40–12:25 pm: Wade Harper, Professor of Pathology, Department of Pathology, Harvard Medical School
"The SLX4 complex, a tool kit for DNA repair"
 

12:25–1:45 pm: Lunch in the Harvard School of Public Health Cafeteria

1:45–4:30 pm: Session III
Discussion leader: Gökhan S. Hotamisligil, J.S. Simmons Professor of Genetics and Metabolism, Chair, Department of Genetics and Complex Diseases, Harvard School of Public Health

1:45–1:50 pm: Introduction

1:50–2:35 pm: Toren Finkel, Chief, Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
"Mitochondrial function and oxidative stress in stem and progenitor cell function"
2:35–3:20 pm: Marcia Haigis, Assistant Professor, Department of Pathology, Harvard Medical School
"Roles of sirtuins in mitochondrial metabolism"
 
3:20–4:05 pm: Laura Niedernhofer, Associate Professor, Department of Microbiology and Molecular Genetics, University of Pittsburgh
"Therapeutic strategies for delaying aging"
 
4:05–4:30 pm: General Discussion and Closing Remarks