Lu Qi

Research Scientist

Department of Nutrition

Building II, Room 310
luqi@hsph.harvard.edu

Research

Dr. Qi's major research interests include:

  1. Genetic/molecular Epidemiology of type 2 diabetes, cardiovascular complications, and obesity.
  2. Gene-environment interactions in relation to type 2 diabetes and cardiovascular complications.
  3. Epidemiology of diet and lifestyle on type 2 diabetes and cardiovascular disease.

Dr. Qi's research has focused on the genetic determinants and gene-environment interactions in relation to obesity, type 2 diabetes and the cardiovascular complications in diabetic patients. He has also concentrated the biochemical markers especially adipokines and inflammatory cytokines in predicting diabetes and cardiovascular complications. Dr. Qi is the Principal Investigator of the American Heart Association Scientist Development Grant on the biochemical and genetic predictors for cardiovascular disease in diabetes.

Education

MD, 1993, Beijing Medical University (Currently as Peking University Health Science Center), China

MS, 1996, Chinese Center for Disease Prevention, China

PhD, 2004. Tufts University, Boston, MA

Publications

Ordovas JM, Qi L, Shen H, Mayer J. Is IL12B a potential genetic target for the prevention of type 1 diabetes through dietary intervention? Nutr Rev. 2002 Jun;60(6):182-6.

 

Qi L and Chen Junshi. Diet and Genome: the New Frontier for Nutrition Science. Acta Nutrimenta Sinica. 2003; 25(1):1-6

 

Qi L, Shen H, Ordovas JM. Hearts and bones. Nutr Metab Cardiovasc Dis. 2003;13(3):165-74

 

Qi L, Shen H, Larson I, Barnard JR, Schaefer EJ, Ordovas JM. Hormone sensitive lipase gene LIPE 14672C>G (HSL –60C>G) substitution and a novel intron polymorphism LIPE 17948C>T associated with cholesterol and fasting glucose levels in American overweight population: the modification by alcohol consumption. Clin Genet. 2004 Feb;65(2):93-100.

 

Qi L, Corella D, Sorlí J, Portolés O, Shen H, Greenberg A, Coltell O, Godoy D, Ordovás JM. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clin Genet. 2004 Oct;66(4):299-310.

 

Qi L, Shen H, Larson I, Schaefer E, Greenberg A, Corella D, Tregouet D, and Ordovas J. Gender-specific association of a perilipin gene haplotype with obesity risk in a white population. Obes Res. 2004 Nov;12(11):1758-65.

 

Qi L, Shen H, Tai S, Tan C, Chew S, Greenberg A, Corella D, and Ordovas J. Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multi-ethnic Asian population. J Mol Med. 2005 Jun;83(6):448-56.

 

Qi L, Rimm E, Liu S, Rifai N, and Hu F. Dietary glycemic index, glycemic load, cereal fiber and plasma adiponectin concentration in diabetic men. Diabetes Care. 2005 May;28(5):1022-8.

 

Qi L, Li T, Rimm E, Zhang C, Rifai N, Hunter D, Doria A, and Hu F. The +276 polymorphism of the APM1 gene and plasma adiponectin concentration and cardiovascular risk in diabetic men. Diabetes. 2005 May;54(5):1607-10.

 

Corella D, Qi L, Sorli JV, Godoy D, Portoles O, Coltell O, Greenberg AS, Ordovas JM. Obese subjects carrying the 11482G>A polymorphism at the perilipin (PLIN) locus are resistant to weight loss following dietary energy restriction. J Clin Endocrinol Metab. 2005 Jun 28

 

Qi L, Meigs J, Manson J, Ma J, Hunter D, Rifai N, and Hu F. HFE genetic variability, dietary iron intake, body iron stores and the risk of type 2 diabetes in US women. Diabetes. 2005 Dec;54(12):3567-72.

 

Qi L, van Dam R, Mantzoros C, and Hu F. The Association between Whole Grain, Bran, and Cereal Fiber Intakes and Markers of Systemic Inflammation in Diabetic Women. Diabetes Care. 2006 Feb;29(2):207-11.

 

Qi L, Manson J, Meigs J, Doria A, Hunter D, Mantzoros C, and Hu F. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes, 2006, 55(5):1512-6

 

Corella D, Qi L, Tai ES, Deurenberg-Yap M, Tan CE, Chew SK, Ordovas JM. Perilipin Gene Variation Determines Higher Susceptibility to Insulin Resistance in Asian Women When Consuming a High-Saturated Fat, Low-Carbohydrate Diet.
Diabetes Care. 2006 Jun;29(6):1313-1319.

 

Qi L, van Dam R, Meigs J, Manson J, Hunter D, and Hu F. IL-6 genetic variability and type 2 diabetes: Large-scale case-control study and meta-analysis. Hum Mol Genet. 2006 Jun 1;15(11):1914-20.

 

Shen H, Qi L, Tai E, Chew S, Tan C, Ordovas J. Uncoupling Protein 2 Promoter Polymorphism -866G/A, Central Adiposity, and Metabolic Syndrome in Asians. Obesity (Silver Spring). 2006 Apr;14(4):656-61.

 

Qi L, Meigs J, Liu S, Manson J, Mantzoros C, and Hu F. Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes. Diabetes Care, 2006 Jul;29(7):1501-5. 

 

Qi L, Liu S, Rifai N, Hunter D, and Hu F. Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL levels in women with type 2 diabetes. Atherosclerosis. 2006 Jun 15

 

Zhang C, Qi L, Hunter D, Manson J, van Dam R, Hu F. Variant of transcription factor 7-like 2 (TCF7L2) and the risk of type 2 diabetes mellitus in large cohorts of U.S. men and women. Diabetes. 2006 Sep;55(9):2645-8.

 

Lopez-Garcia E, van Dam R, Qi L, Hu F. Coffee consumption and markers of inflammation and endothelial dysfunction among healthy and diabetic women. Am J Clin Nutr. 2006 Oct;84(4):888-93.

 

Qi L, van Dam R, Rexrode K, Hu F. Heme iron from diet as a risk factor for coronary heart disease in women with type 2 diabetes. Diabetes Care. 2007 Jan;30(1):101-6.

 

Qi L and Hu F. Influence of Dietary Glycemic Load and Whole Grain Intakes on Systemic Inflammation in Diabetic Patients. Curr Opin Lipidol. 2007 Feb;18(1):3-8.

 

Qi L, Doria A, Giorgi E, and Hu F. Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in US women: A tagging-SNP haplotype analysis. Diabetes. 2007 Jun;56(6):1586-91.

 

Gao X, Qi L, Qiao N, Hyon C, Curhan G, Tucker K, and Ascherio A. Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women. Hypertension, 2007 Aug;50(2):306-12.

 

Qi L, van Dam R, Asselbergs F, and Hu F. Gene-gene interactions between HNF4A and KCNJ11 in predicting type 2 diabetes among women. Diabet Med. 2007, (in press)

 

Qi L, Zhang C, van Dam R, and Hu F. Interleukin-6 gene and adiposity: associations in two independent cohorts and systematic review in 26,944 individuals. J Clin Endocrinol Metab., 2007 (in press)