The Environmental Genomics Core assists in conducting human genome-wide association studies and candidate gene studies, and in preparation of DNA for genetic and epigenetic studies. We provide services in two main ways: by supporting mini-projects that help the Center investigator to become more competitive for applying for grants that involve, for them, a new area of investigation (genetics/ gene-environment interactions); and as a consultative and training service for Center investigators and their trainees to acquire basic skills in environmental genetics.
Services
- DNA and RNA extraction and quality testing
- Choice of genotyping platforms
- Gene expression analyses
- Genome and epigenome-wide analyses
- Consultation on study design for gene-environment research
- Biorepository for DNA samples
Equipment
- ABI Taqman 7900HT Fast Real time PCR system
- Gentra AutoPure DNA extraction machine
- Promega Maxwell 16 Auto Tissue sample RNA /DNA extraction machine
- Spectra Max M5 384-well DNA/RNA/protein/Elisa Quantitator (Pico Green)
- Beckman Coulter Biomek 2000 Laboratory Automation System (96/384 wells)
- 5 Geneamp PCR 9700 Machines
- 5 DNA Engine 2 x 384-well PCR Peltier Thermal Cyclers
- Pharmacia Biotech DNA/RNA Quantitainer
- Base Runner 200 Nucleic Acid Sequencer (Dual Capacity)
- Illumina Beadexpress Instrument
How to Apply for Services
To obtain services from either internal HSPH or external collaborating facilities, NIEHS Center investigators may apply for facility use or funds by completing as simple, single page application that details the service, cost, and relevance to the NIEHS Center research mission. Applications should be returned to Ms. Li Su, Research Specialist and Service Coordinator, or Dr. David Christiani, Environmental Genomics Core Director. Applications are reviewed by Dr. Christiani, and two other Center Executive Committee members.
Funds for services are distributed through billing codes for internal facilities or purchase orders for external facilities. For more information and to engage the service of the facility, please contact Li Su.
People
- Director: David Christiani, Professor of Occupational Medicine and Epidemiology, Department of Environmental Health and Department of Epidemiology; Professor of Medicine, Harvard Medical School
- Administrator: John Yong
- Service Coordinator: Li Su
