Publications

Chagas Disease

1) Campos, M.A., Closel, M., Valente, E.P., Cardoso, J.E., Akira, S., Alvarez-Leite, J.I., Ropert, C., Gazzinelli, R.T. (2004). Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.  Journal of Immunology 172: 1711-1718.

2) Bartholomeu, D.C., Ropert, C., Melo, M.B., Parroche, P.,  Junqueira, C.F., Teixeira, S.M., Sirois, C., Kasperkovitz, P.,  Knetter, C.F., Lien, E., Latz, E., Golenbock, D.T., Gazzinelli, R.T. (2008).  Recruitment and Endo-Lysosomal activation of TLR9 in Dendritic cells infected with Trypanosoma cruzi. Journal of Immunology 181:1333-1344.

3) Caetano, B.C., Carmo, B.B., Melo, M.B., Cerny, A., dos Santos, S.L., Bartholomeu, D.C., Golenbock, D.T., Gazzinelli, R.T. (2011) Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. Journal of Immunology 187:1903-1911.

4) Junqueira, C., Santos, L.I., Galvão-Filho, B., Teixeira, S.M., Rodrigues, F.G., DaRocha, W.D., Chiari, E., Jungbluth, A.A., Ritter, G., Gnjatic, S., Old, L.J., Gazzinelli, R.T.  (2011). Trypanosoma cruzi as an effective cancer antigen delivery vector. Proceeding of the National Academy of Sciences USA 108:19695-19700.

 

Malaria

             1) Parroche, P., Lauwn, F.N., Goutagny, N., Latz, E., Monks, B.G., Visintin, A., Halmen, K.A., Lamphier, M., Olivier, M., Bartholomeu, D.C., Gazzinelli, R.T., Golenbock, D.T. (2007). Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting DNA to Toll-Like receptor 9. Proceedings of the National Academy of Sciences USA 104:1919-1924..

2) Franklin, B.S., Parroche, P., Lauw, F., Ropert, C., Ataide, M. A., de Oliveira, R., Pereira, D., Tada, M.S., Nogueira, P., Pereira da Silva, L.H. Björkbacka, H., Golenbock, D.T., Gazzinelli, R.T.  (2009) Malaria primes the innate immune response due to interferon- induced enhancement of toll-like receptor expression and function. Proceedings of the National Academy of Sciences USA 106:5789-5794.

3) Sharma, S., DeOliveira, R.B., Kalantari, P., Parroche, P., Goutagny, N., Jiang, Z., Chan, J., Bartholomeu, D.C., Lauw, F., Hall, J.P., Barber, G.N., Gazzinelli, R.T., Fitzgerald, K.A., Golenbock, D.T. (2011)Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity 35:194-207.

4) Franklin, B.S., Ishizaka, S.T., Lamphier, M., Gusovsky, F., Hansen, H., Rose, J., Zheng, W., Ataíde, M.A., de Oliveira, R.B., Golenbock, D.T., Gazzinelli, R.T. (2011). Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proceedings of the National Academy of Sciences USA 108:3689-3694.

5) Kalantari, P., Deoliveira, R.B., Chan, J., Corbett , Y., Rathinam, V., Stutz, A., Latz, E., Gazzinelli, R.T., Golenbock, D.T., Fitzgerald, K.A. (2013) Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria. Cell Reports. pii: S2211-1247(13)00759-6.

6) Ataide, M.A., Andrade, W.A., Zamboni, D.S., Wang, D., Souza, M.C., Franklin, B.S., Elian, S., Martins, F.S., Pereira, D., Reed, G., Fitzgerald, K.A., Golenbock, D.T., Gazzinelli, R.T. (2014) Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection. PLoS Pathog 10 (1): e1003885.

 

Toxoplasmosis

1) Melo, M.B., Kasperkovitz, P., Cerny, A., Könen-Waisman ,S., Kurt-Jones, E.A., Lien, E., Beutler, B., Howard, J.C., Golenbock, D.T., Gazzinelli, R.T. (2010). UNC93B1 mediates host resistance to infection with Toxoplasma gondii. PLoS Pathogens 6:e1001071.

2) Béla, S.R., Dutra, M.S., Mui, E., Montpetit, A., Oliveira, F.S., Oliveira, S.C., Arantes, R.M., Antonelli, L.R., McLeod, R., Gazzinelli, R.T. (2012). Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii. Infection and Immunity 80:4298-4308.

3) Dutra, M.S., Béla, S.R., Peixoto-Rangel, A.L., Fakiola, M., Cruz, A.G., Gazzinelli, A., Quites, H.F., Bahia-Oliveira, L.M., Peixe, R.G., Campos, W.R., Higino-Rocha, A.C., Miller, N.E., Blackwell, J.M., Antonelli, L.R., Gazzinelli, R.T. (2013) Association of a NOD2 gene polymorphism and T-Helper 17 cells with presumed ocular toxoplasmosis. Journal of Infectious Diseases 207:152-163.

4) Andrade, W.A., Souza, M.C., Ramos-Martinez, E., Nagpal, K., Dutra, M.S., Melo, M.B., Bartholomeu, D.C., Ghosh, S., Golenbock, D.T., Gazzinelli, R.T. (2013) Combined action of nucleic acid-sensing Toll-like Receptors and TLR11/TLR12 imparts resistance to Toxoplasma gondii in mice. Cell Host and Microbe 13:42-53.

  

Visceral Leishmaniasis

1) Resende, D.M., Caetano, B.C., Dutra, M., Penido, M., Abrantes, C., Verly, R., Resende, J., Piloveloso, D., Rezende, S., Bruna-Romero, O., Fernandes, A.P., Gazzinelli, R.T. (2008).  Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen: Correlation with IFN-g and cytolytic activity by CD8+ T cells. Vaccine 26:4585-4593.

2) Fernandes, A., Costa, M., Coelho, E., Michalick, M., Defreitas, E., Melo, M., Luiztafuri, W., Resende, D., Hermont, V., Abrantes, C., Gazzinelli, R.T. (2008).  Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein. Vaccine 26: 5888-5895.

3) Costa, M.M., Andrade, H.M., Bartholomeu, D.C., Freitas, L.M., Pires, S.F., Chapeaurouge, A.D., Perales, J., Ferreira, A.T., Giusta, M.S., Melo, M.N., Gazzinelli, R.T. (2011). Analysis of Leishmania chagasi by 2-D difference gel electrophoresis (2-D DIGE) and immunoproteomic: identification of novel candidate antigens for diagnostic test and vaccine. Journal of Proteome Research 10:2172-2184.

Critical Reviews                 

1) Gazzinelli R.T., Denkers, E.Y. (2006). Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism. Nature Reviews Immunology 6:895-906.

2) Junqueira, C., Caetano, B., Bartholomeu, D.C., Melo, M.B., Ropert, C., Rodrigues, M.M., Gazzinelli, R.T. (2010). The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease. Expert Review of Molecular Medicine 12:e29.

             3) Fernandes, A.P., Coelho, E.A., Machado-Coelho, G.L., Grimaldi, G.Jr., Gazzinelli, R.T. (2012). Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives.Current Opinion in Microbiology 15:476-485.

            4) Gazzinelli, R.T., Mendonça-Neto, R., Howard, J., Lilue, J., Sher, A. (2014) Innate sensing of Toxoplasma gondii: an evolutionary tale of mice, cats and men. Cell Host & Microbe 15:132-138.