20130622-20130622-KRS_5680-2

Sara Lindstroem

Research Scientist

Department of Epidemiology

(Sara Lindstrom)

Department of Epidemiology

655 Huntington Avenue
Building 2, Room 249B
Boston, Massachusetts 02115
Phone: 617.432.7681

Research Interests

I am a Research Scientist in the Program of Genetic Epidemiology and Statistical Genetics. My research focuses on identifying genetic and environmental risk factors for common diseases, specifically breast and prostate cancer. I am also interested in statistical methods used in genetic epidemiology, mainly in population-based case-control studies.

My current projects include genome-wide association studies (GWAS), next-generation sequencing, shared heritability between correlated traits and gene-environment interactions. I am also deeply involved in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3), the Marker of Density (MODE) Consortium and coordinate the post-GWAS “Discovery, Biology, and Risk of Inherited Variants in Breast Cancer” (DRIVE) study.

Education

Post-doctoral training, 2008-2010, Harvard School of Public Health, Boston, MA.

Ph.D., 2007, Umeå Universitet, Umeå, Sweden. Thesis Title: “Genetic variation and prostate cancer”

M.Sc. in Engineering Physics, 2004, Umeå Universitet, Umeå, Sweden

Selected Publications

Lindström S, Thompson DJ, Paterson AD, (39 other authors), Boyd NF, Vachon CM, Tamimi RM. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Nature Commun. 2014 Oct 24;5:5303.

Cao Y, Lindström S, Schumacher F, (28 other authors), Pollak M, Lin X, Ma J. Insulin-like Growth Factor Pathway Genetic Polymorphisms, Circulating IGF1 and IGFBP3, and Prostate Cancer Survival. J Natl Cancer Inst. 2014 May 13;106(6)

Garcia-Closas M*, Couch, FJ*, Lindström S*, Michailidou K*, Schmidt MK*, (261 other authors), Pharoah P, Vachon C, Easton DF, Haiman CA, Kraft P. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013 Apr;45(4):392-8. *These authors contributed equally to this work.

Zaitlen N, Lindström S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeböller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, Landi MT, Langefeld CD, Le Marchand L, Meister M, Morgan AW, Raji OY, Risch A, Rosenberger A, Scherf D, Steer S, Walshaw M, Waters KM, Wilson AG, Wordsworth P, Zienolddiny S, Tchetgen ET, Haiman C, Hunter DJ, Plenge RM, Worthington J, Christiani DC, Schaumberg DA, Chasman DI, Altshuler D, Voight B, Kraft P, Patterson N, Price AL. Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet. 2012 Nov;8(11):e1003032.

Lindström S, Schumacher FR, Cox D, Travis RC, Albanes D, Allen NE, Andriole G, Berndt SI, Boeing H, Bueno-de-Mesquita HB, Crawford ED, Diver WR, Gaziano JM, Giles GG, Giovannucci E, Gonzalez CA, Henderson B, Hunter DJ, Johansson M, Kolonel LN, Ma J, Le Marchand L, Pala V, Stampfer M, Stram DO, Thun MJ, Tjonneland A, Trichopoulos D, Virtamo J, Weinstein SJ, Willett WC, Yeager M, Hayes RB, Severi G, Haiman CA, Chanock SJ, Kraft P. Common genetic variants in prostate cancer risk prediction–results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). Cancer Epidemiol Biomarkers Prev. 2012 Mar;21(3):437-44.

Campa D, Kaaks R, Le Marchand L, Haiman CA, Travis RC, Berg CD, Buring JE, Chanock SJ, Diver WR, Dostal L, Fournier A, Hankinson SE, Henderson BE, Hoover RN, Isaacs C, Johansson M, Kolonel LN, Kraft P, Lee IM, McCarty CA, Overvad K, Panico S, Peeters PH, Riboli E, Sanchez MJ, Schumacher FR, Skeie G, Stram DO, Thun MJ, Trichopoulos D, Zhang S, Ziegler RG, Hunter DJ, Lindström S, Canzian F. Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. J Natl Cancer Inst. 2011 Aug 17;103(16):1252-63.

Lindström S, Vachon CM, Li J, Varghese J, Thompson D, Warren R, Brown J, Leyland J, Audley T, Wareham NJ, Loos RJ, Paterson AD, Rommens J, Waggott D, Martin LJ, Scott CG, Pankratz VS, Hankinson SE, Hazra A, Hunter DJ, Hopper JL, Southey MC, Chanock SJ, Silva ID, Liu J, Eriksson L, Couch FJ, Stone J, Apicella C, Czene K, Kraft P, Hall P, Easton DF, Boyd NF, Tamimi RM. Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nat Genet. 2011 Mar;43(3):185-7.

Lindström S, Adami HO, Adolfsson J, Wiklund F. Y chromosome haplotypes and prostate cancer in Sweden. Clin Cancer Res. 2008 Oct 15;14(20):6712-6.

Lindström S, Adami HO, Balter KA, Xu J, Zheng SL, Sun J, Stattin P, Gronberg H, Wiklund F. Inherited genetic variation in hormone regulating genes and prostate cancer survival. Clin Cancer Res. 2007 Sep 1;13(17):5156-6

Lindström S, Wiklund F, Adami HO, Balter KA, Adolfsson J, Gronberg H. Germ-Line Genetic Variation in the Key Androgen-Regulating Genes Androgen Receptor, Cytochrome P450, and Steroid-5-{alpha}-Reductase Type 2 Is Important for Prostate Cancer Development. Cancer Res. 2006 Nov 15;66(22):11077-83 Dec;118(3-4):339-47