20130622-20130622-KRS_5680-2

Sara Lindstroem

Research Scientist

Department of Epidemiology

(Sara Lindstrom)

Department of Epidemiology

655 Huntington Avenue
Building 2, Room 249B
Boston, Massachusetts 02115
Phone: 617.432.7681

Research Interests

I am a Research Scientist in the Program of Molecular and Genetic Epidemiology. My research focuses on identifying genetic and environmental risk factors for common diseases, specifically breast and prostate cancer. I am also interested in statistical methods used in genetic epidemiology, mainly in population-based case-control studies.

My current projects include genome-wide association studies (GWAS), next-generation sequencing, genetic risk prediction and detection of gene x gene and gene x environment interactions. I am also deeply involved in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3), the Marker of Density (MODE) Consortium and coordinate the post-GWAS “Discovery, Biology, and Risk of Inherited Variants in Breast Cancer” (DRIVE) study.

Education

Post-doctoral training, 2008-2010, Harvard School of Public Health, Boston, MA.

Ph.D., 2007, Umeå Universitet, Umeå, Sweden. Thesis Title: “Genetic variation and prostate cancer”

M.Sc. in Engineering Physics, 2004, Umeå Universitet, Umeå, Sweden

Selected Publications

Garcia-Closas M*, Couch, FJ*, Lindström S*, Michailidou K*, Schmidt MK*, (261 other authors), Pharoah P, Vachon C, Easton DF, Haiman CA, Kraft P. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013 Apr;45(4):392-8. *These authors contributed equally to this work.

Zaitlen N, Lindström S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeböller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, Landi MT, Langefeld CD, Le Marchand L, Meister M, Morgan AW, Raji OY, Risch A, Rosenberger A, Scherf D, Steer S, Walshaw M, Waters KM, Wilson AG, Wordsworth P, Zienolddiny S, Tchetgen ET, Haiman C, Hunter DJ, Plenge RM, Worthington J, Christiani DC, Schaumberg DA, Chasman DI, Altshuler D, Voight B, Kraft P, Patterson N, Price AL. Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet. 2012 Nov;8(11):e1003032.

Stevens KN, Lindström S, Scott CG, Thompson D, Sellers TA, Wang X, Wang A, Atkinson E, Rider DN, Eckel-Passow JE, Varghese JS, Audley T, Brown J, Leyland J, Luben RN, Warren RM, Loos RJ, Wareham NJ, Li J, Hall P, Liu J, Eriksson L, Czene K, Olson JE, Pankratz VS, Fredericksen Z, Diasio RB, Lee AM, Heit JA, Deandrade M, Goode EL, Vierkant RA, Cunningham JM, Armasu SM, Weinshilboum R, Fridley BL, Batzler A, Ingle JN, Boyd NF, Paterson AD, Rommens J, Martin LJ, Hopper JL, Southey MC, Stone J, Apicella C, Kraft P, Hankinson SE, Hazra A, Hunter DJ, Easton DF, Couch FJ, Tamimi RM, Vachon CM. Identification of a novel percent mammographic density locus at 12q24. Hum Mol Genet. 2012 Jul 15;21(14):3299-305.

Lindström S, Schumacher FR, Cox D, Travis RC, Albanes D, Allen NE, Andriole G, Berndt SI, Boeing H, Bueno-de-Mesquita HB, Crawford ED, Diver WR, Gaziano JM, Giles GG, Giovannucci E, Gonzalez CA, Henderson B, Hunter DJ, Johansson M, Kolonel LN, Ma J, Le Marchand L, Pala V, Stampfer M, Stram DO, Thun MJ, Tjonneland A, Trichopoulos D, Virtamo J, Weinstein SJ, Willett WC, Yeager M, Hayes RB, Severi G, Haiman CA, Chanock SJ, Kraft P. Common genetic variants in prostate cancer risk prediction–results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). Cancer Epidemiol Biomarkers Prev. 2012 Mar;21(3):437-44.

Campa D, Kaaks R, Le Marchand L, Haiman CA, Travis RC, Berg CD, Buring JE, Chanock SJ, Diver WR, Dostal L, Fournier A, Hankinson SE, Henderson BE, Hoover RN, Isaacs C, Johansson M, Kolonel LN, Kraft P, Lee IM, McCarty CA, Overvad K, Panico S, Peeters PH, Riboli E, Sanchez MJ, Schumacher FR, Skeie G, Stram DO, Thun MJ, Trichopoulos D, Zhang S, Ziegler RG, Hunter DJ, Lindström S, Canzian F. Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. J Natl Cancer Inst. 2011 Aug 17;103(16):1252-63.

Lindström S, Vachon CM, Li J, Varghese J, Thompson D, Warren R, Brown J, Leyland J, Audley T, Wareham NJ, Loos RJ, Paterson AD, Rommens J, Waggott D, Martin LJ, Scott CG, Pankratz VS, Hankinson SE, Hazra A, Hunter DJ, Hopper JL, Southey MC, Chanock SJ, Silva ID, Liu J, Eriksson L, Couch FJ, Stone J, Apicella C, Czene K, Kraft P, Hall P, Easton DF, Boyd NF, Tamimi RM. Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nat Genet. 2011 Mar;43(3):185-7.

Lindström S, Ma J, AltshulerD, Giovannucci E, RiboliE, Albanes D, AllenN, BerndtS, BoeingH, Bueno-de-MesquitaH, Chanock S, DunningA, FeigelsonH, GazianoJ, HaimanC, HayesR, HenderssonB, HunterD, KaaksR, KolonelL, Le MarchandL, MartínezC, Overvad K, SiddiqA, StampferM, StattinP, StramD, ThunM, TrichoupolosD, TuminoR, WeinsteinS, YeagerM, KraftP,Freedman M. A large study of Androgen Receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). J Clin Endocrinol Metab. 2010 Sep;95(9):E121-7.

Lindström S, Adami HO, Adolfsson J, Wiklund F. Y chromosome haplotypes and prostate cancer in Sweden. Clin Cancer Res. 2008 Oct 15;14(20):6712-6.

Lindström S, Adami HO, Balter KA, Xu J, Zheng SL, Sun J, Stattin P, Gronberg H, Wiklund F. Inherited genetic variation in hormone regulating genes and prostate cancer survival. Clin Cancer Res. 2007 Sep 1;13(17):5156-6

Lindström S, Wiklund F, Adami HO, Balter KA, Adolfsson J, Gronberg H. Germ-Line Genetic Variation in the Key Androgen-Regulating Genes Androgen Receptor, Cytochrome P450, and Steroid-5-{alpha}-Reductase Type 2 Is Important for Prostate Cancer Development. Cancer Res. 2006 Nov 15;66(22):11077-83 Dec;118(3-4):339-47