Publications

Publications

1.     Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, and Ernst JD. Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms.  J Immunol. 2004 May 15;172(10):6272-80. PMID: 15128816.

2.     Fortune SM, Jaeger A, Sarracino DA, Chase MR, Sassetti CM, Sherman DR, Bloom BR and Rubin EJ.  Mutually-dependent secretion of proteins required for mycobacterial virulence.   PNAS, 2005 Jul 26;102(30):10676-81.  PMCID: PMC1176248.

3.     Joshi S, Pandey AK, Capite N, Fortune SM, Rubin EJ, Sassetti CM.   Characterization of Mycobacterial Virulence Genes through Genetic Interaction Mapping.   PNAS, 2006 Aug 1;103(31):11760-5.  PMCID: PMC1544243.

4.     Hett EC, Chao MC, Steyn AJ, Fortune SM, Deng LL and Rubin EJ.  A partner for the resuscitation promoting factors of Mycobacterium tuberculosis.  Mol Micro., 2007, Oct 6(3); 66:658-668. PMID: 17919286.

5.     Woodworth, JS, Fortune SM and Behar SM.  Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10.  Infect Immun, 2008, Jul 7; 76(9) 4199-4205. PMCID: PMC2519428.

6.     Pandey AK, Yang Y, Jiang Z, Fortune SM, Coulombe F, Behr MA, Fitzgerald KA, Sassetti CM and Kelliher MA.  NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis.  PLOSPathogens, 2009, Jul;5(7):e1000500. PMCID: PMC269812.

7.     Divangahi M, Chen M, Gan H, Desjardins D, Hickman TT, Lee DM, Fortune S, Behar SM, Remold HG.  Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair.  Nat Immunol. 2009 Aug;10(8):899-906.  PMCID: PMC2730354.

8.     Siegrist MS, Unnikrishnan M, McConnell MJ, Borowsky M, Cheng TY, Siddiqi N, Fortune SM, Moody DB, Rubin EJ.  Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition.  PNAS, 2009 Nov 3;106(44):18792-7. Epub 2009 Oct 21.  PMCID: PMC2774023.

9.     Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR Jr, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. J Bacteriol. 2010 Jul;192(14):3645-53. Epub 2010 May 14. PMCID: PMC2897344.

10.  Garces A, Atmakuri K, Chase MR, Woodworth JS, Krastins B, Rothchild AC, Ramsdell TL, Lopez MF, Behar SM, Sarracino DA, Fortune SMEspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity.  PLoSPathogens. 2010 Jun 24;6(6):e1000957. PMCID: PMC2891827

11.  Woodworth JS, Shin D, Volman M, Nunes-Alves C, Fortune SM, Behar SM.   Mycobacterium tuberculosis Directs Immunofocusing of CD8+ T Cell Responses Despite Vaccination. J Immunol. 2011 Feb 1:186(3):1627-37. Epub 2010 Dec 22.

12. Millington KA, Fortune SM, Low J, Garces A, Hingley-Wilson SM, Wickremasignhe M, Kon OM, Lalvani A. EspC is a highly immunodominant ESX-1-dependent secreted antigen specific for M. tuberculosis infection.   PNAS, 2011 Apr 5;108(14):5730-5. PMCID: PMC3078386

13.  Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan JE, Ioerger TR, Mohaideen N, Sacchettini J, Lipsitch M, Flynn JL and Fortune SM. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nat Genet. 2011 May;43(5):482-6. Epub 2011 Apr 24.  PMID: 21516081 [PubMed – in process].

14.  Sille F, Martin C, Jayaraman P, Rothchild A, Fortune S, Besra G, Behar S, Boes M.  Requirement for Invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation. Infect Immun. 2011 Aug;79(8):3053-63. Epub 2011 May 16. PMCID: PMC3147586.

15. Liong M, Fernandez-Suarez M, Issadore D, Min C, Tassa C, Reiner T, Fortune SM, Toner M, Lee H, Weissleder R. Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjug Chem. 2011 Dec 21;22(12):2390-4. Epub 2011 Nov 7. PMCID: PMC3263317.

16. Millington KA, Fortune SM, Low J, Garces A, Hingley-Wilson SM, Wickremasinghe M, Kon OM, Lalvani A. Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5730-5. Epub 2011 Mar 22. PMCID:PMC3078386.

17.  Aldridge BB, Fernandez-Suarez M, Heller D, Ambravaneswaran V, Irimia D, Toner M, Fortune SM. Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science. 2012 Jan 6;335(6064):100-4. Epub 2011 Dec 15.  PMCID:PMC3397429.

18. Wirth SE, Krywy JA, Aldridge BB, Fortune SM, Fernandez-Suarez M, Gray TA, Derbyshire KM.  Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria. Mol Microbiol. 2012 Feb;83(3):654-64. Epub 2012 Jan 11.PMCID:PMC3277861.

19. Lee HJ, Lang PT, Fortune SM, Sassetti CM, Alber T. Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis.  Nat Struct Mol Biol. 2012 Aug;19(8):811-8. Epub 2012 Jul 8.PMCID:PMC3414669.

20. Martin CJ, Booty MG, Rosebrock TR, Nunes-Alves C, Desjardins DM, Keren I, Fortune SM, Remold HG, Behar SM. Efferocytosis is an innate antibacterial mechanism. Cell Host Microbe. 2012 Sep 13;12(3):289-300. PMCID:PMC3517204.

21. Fortune SMThe surprising diversity of Mycobacterium tuberculosis: change you can believe in.  J Infect Dis. 2012 Dec 1;206(11):1642-4. Epub 2012 Sep 14. PMID:22984117.

22. Shell SS, Prestwich EG, Baek SH, Shah RR, Sassetti CM, Dedon PC, Fortune SM. DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. PLoS Pathog. 2013;9(7):e1003419. Epub 2013 Jul 4.PMCID:PMC3701705.

23. Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C, Shah RR, Ahmad R, Fernandez-Suarez M, Fortune SM, Toner M, Lee H, Weissleder R. Magnetic barcode assay for genetic detection of pathogens. Nat Commun. 2013;4:1752. PMCID:PMC3635151.

24. Chao MC, Kieser KJ, Minami S, Mavrici D, Aldridge BB, Fortune SM, Alber T, Rubin EJ. Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria. PLoS Pathog. 2013 Feb;9(2):e1003197.PMCID:PMC3585148.

25. Ragheb MN, Ford CB, Chase MR, Lin PL, Flynn JL, Fortune SM. The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection. BMC Genomics. 2013 Mar 5;14:145.PMCID:PMC3635867.

26. Fong EJ, Sharma Y, Fallica B, Tierney DB, Fortune SM, Zaman MH.  Decoupling directed and passive motion in dynamic systems: particle tracking microrheology of sputum. Ann Biomed Eng. 2013 Apr;41(4):837-46. Epub 2012 Dec 28.PMCID:PMC3763957.

27. Ford CB, Shah RR, Maeda MK, Gagneux S, Murray MB, Cohen T, Johnston JC, Gardy J, Lipsitch M, Fortune SM. Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis. Nat Genet. 2013 Jul;45(7):784-90. Epub 2013 Jun 9.PMCID:PMC3777616.

28. Huppert LA, Ramsdell TL, Chase MR, Sarracino DA, Fortune SM, Burton BM. The ESX system in Bacillus subtilis mediates protein secretion. PLoS One. 2014 May 5;9(5):e96267. eCollection 2014.PMCID:PMC4010439.

29. Lin PL, Ford CB, Coleman MT, Myers AJ, Gawande R, Ioerger T, Sacchettini J, Fortune SM, Flynn JL. Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing. Nat Med. 2014 Jan;20(1):75-9. Epub 2013 Dec 15.PMCID:PMC3947310.

30.  Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB. Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2978-83. Epub 2014 Feb 10.PMCID:PMC3939896.

31.  Kester JC, Fortune SM. Persisters and beyond: mechanisms of phenotypic drug resistance and drug tolerance in bacteria. Crit Rev Biochem Mol Biol. 2014 Mar-Apr;49(2):91-101. Epub 2013 Dec 13. PMID:24328927.

32. Ramsdell TL, Huppert LA, Sysoeva TA, Fortune SM, Burton BM. Linked Domain Architectures Allow for Specialization of Function in the FtsK/SpoIIIE ATPases of ESX Secretion Systems.  J Mol Biol. 2014 Jun 27. pii: S0022-2836(14)00306-4.  [Epub ahead of print]. PMID:24979678