Secondary Faculty

Sengwee Darren Toh

Professor in the Department of Epidemiology

Epidemiology

darren_toh@hphci.harvard.edu

Other Positions

Professor of Population Medicine

Population Medicine

Harvard Medical School

Links

Department Google Scholar Catalyst Profile Twitter

Overview

Darren Toh, ScD is Professor in the Department of Population Medicine at Harvard Medical School and Harvard Pilgrim Health Care Institute. He is a pharmacoepidemiologist with an interest in the comparative safety and effectiveness research of medical products. His research focuses on 1) assessing the risks and benefits of medical products using electronic data collected as part of routine healthcare delivery, and 2) developing and applying privacy-protecting analytic methods to conduct multi-center studies in distributed data networks.

Darren is Chief Scientist at the Operations Center of the FDA-funded Sentinel System, a congressionally mandated national medical product safety surveillance system. He is Principal Investigator of projects funded by the National Institutes of Health (U01EB023683), the Agency for Healthcare Research and Quality (R01HS026214), the Patient-Centered Outcomes Research Institute (ME-1403-11305), and the Food and Drug Administration. Darren received his doctoral degree in Epidemiology from the Harvard School of Public Health.

Bibliography

Real-world Evidence Comparing Tofacitinib and Vedolizumab in Anti-TNF-experienced Patients With Ulcerative Colitis.

Adimadhyam S, Lewis JD, Simon AL, Wolfe AE, Smith S, Hou L, Moyneur É, Reynolds JS, Toh S, Dobes A, Parlett L, Haynes K, Burris J, Dorand JE, Long MD, Kappelman MD.

Inflamm Bowel Dis. 2024 Apr 03. 30(4):554-562. PMID: 37358904

Using Claims Data to Predict Pre-Operative BMI Among Bariatric Surgery Patients: Development of the BMI Before Bariatric Surgery Scoring System (B3S3).

Wong J, Li X, Arterburn DE, Li D, Messenger-Jones E, Wang R, Toh S.

Pragmat Obs Res. 2024. 15:65-78. PMID: 38559704

Targeted Learning with an Undersmoothed Lasso Propensity Score Model for Large-Scale Covariate Adjustment in Healthcare Database Studies.

Wyss R, van der Laan M, Gruber S, Shi X, Lee H, Dutcher SK, Nelson JC, Toh S, Russo M, Wang SV, Desai RJ, Lin KJ.

Am J Epidemiol. 2024 Mar 21. PMID: 38517025

Data-driven automated classification algorithms for acute health conditions: applying PheNorm to COVID-19 disease.

Smith JC, Williamson BD, Cronkite DJ, Park D, Whitaker JM, McLemore MF, Osmanski JT, Winter R, Ramaprasan A, Kelley A, Shea M, Wittayanukorn S, Stojanovic D, Zhao Y, Toh S, Johnson KB, Aronoff DM, Carrell DS.

J Am Med Inform Assoc. 2024 Feb 16. 31(3):574-582. PMID: 38109888

Process guide for inferential studies using healthcare data from routine clinical practice to evaluate causal effects of drugs (PRINCIPLED): considerations from the FDA Sentinel Innovation Center.

Desai RJ, Wang SV, Sreedhara SK, Zabotka L, Khosrow-Khavar F, Nelson JC, Shi X, Toh S, Wyss R, Patorno E, Dutcher S, Li J, Lee H, Ball R, Dal Pan G, Segal JB, Suissa S, Rothman KJ, Greenland S, Hernán MA, Heagerty PJ, Schneeweiss S.

BMJ. 2024 02 12. 384:e076460. PMID: 38346815