Since 2010, I have created a number of new integrative concepts and paradigms, which are listed below.
Molecular pathological epidemiology (MPE). MPE was first described in S Ogino, M Stampfer. J Natl Cancer Inst 2010.
http://jnci.oxfordjournals.org/content/102/6/365.full
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841039/
http://en.wikipedia.org/wiki/Molecular_pathological_epidemiology
Immunology-MPE (including immuno-genomics)
M Song et al. Gut 2016, “Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status”). gut.bmj.com/content/early/2015/01/13/gutjnl-2014-308852.abstract
M Song et al. (JAMA Oncology 2016) have shown that marine omega-3 polyunsaturated fatty acid intake is associated with lower risk of colorectal cancer that contains abundant FOXP3+ Treg cells. www.ncbi.nlm.nih.gov/pubmed/27148825
Y Cao et al. (Gastroenterology 2016) have shown that regular aspirin use is associated with lower risk of colorectal cancer with low-level tumor-infiltrating lymphocytes (TILs). www.ncbi.nlm.nih.gov/pubmed/27475305
M Giannakis et al. (Cell Reports 2016) have shown a positive correlation between neoantigen load (derived from whole exome sequencing data) and T lymphocytic infiltrates. www.ncbi.nlm.nih.gov/pubmed/27149842
Y Masugi et al. (Gut 2016 online) have shown an inverse association between tumor CD274 (PD-L1) expression and FOXP3+ Treg cell density in colorectal cancer, implying mutually alternative mechanisms of immunosuppression. This is one of the largest study on CD274 (PD-L1) expression in colorectal carcinoma. www.ncbi.nlm.nih.gov/pubmed/27196573
R Mehta et al. (JAMA Oncology online) have shown the association of prudent diets with a lower risk of colorectal cancer subtype with PCR-detectable Fusobacterium nucleatum. https://www.ncbi.nlm.nih.gov/pubmed/28125762
Pharmaco-MPE
See https://www.hsph.harvard.edu/shuji-ogino/pharmaco-mpe/
The GWAS-MPE approach. GWAS-MPE, which stands for genome-wide association study-MPE, was first described in S Ogino et al. Gut 2011 (published online in 2010).
http://gut.bmj.com/content/60/3/397.abstract
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040598/
The colorectal continuum model. This model was first described in M Yamauchi et al. Gut 2012.
http://gut.bmj.com/content/early/2012/04/04/gutjnl-2012-302014.extract (the short concept paper which introduced the term “colorectal continuum”.)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345045/ (full text in Pubmed Central.)
http://gut.bmj.com/content/61/6/847.long (this is the original article by M Yamauchi et al. Gut 2012, which tested the colorectal continuum hypothesis.)
The Unique Tumor Principle (UTP). This principle was first described in S Ogino et al. Expert Rev Mol Diagn 2012, and S Ogino, E Giovannucci. Int J Epidemiol 2012.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492839/ (the concept paper which introduced the unique tumor principle)
http://ije.oxfordjournals.org/content/41/4/1072.full (this editorial first appeared in the literature with the unique tumour principle in its title)
The Unique Disease Principle (UDP). This principle was first described in S Ogino et al. Mod Pathol 2013.
http://www.nature.com/modpathol/journal/v26/n4/full/modpathol2012214a.html
The Etiologic Field Effect model. This model was first described in P Lochhead et al. Mod Pathol 2015 (published online in 2014).
http://www.nature.com/modpathol/journal/v28/n1/full/modpathol201481a.html
The lifecourse MPE model. This model was first described in A Nishi et al. Am J Prev Med 2015 (published online in 2014).
http://www.ajpmonline.org/article/S0749-3797(14)00568-6/abstract
The integrative field of Social MPE. This was first described in A Nishi et al. Expert Rev Mol Diagn 2016 (published online in 2015).
http://www.tandfonline.com/doi/full/10.1586/14737159.2016.1115346
