Publications

Publications

Horng, T. mTOR trains heightened macrophage responses. Trends in Immunology, 2014, in press.

Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman H, and Horng, T. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. PNAS, 2014, Oct 28;111(43):15514-9.

Covarrubias AJ and Horng T. IL-6 strikes a balance during metabolic inflammation. Cell Metabolism, 2014 Jun 3;19(6)898-9.

Horng, T. Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome. Trends in Immunology, epub Mar 16, 2014.

Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T.  The TSC-mTOR pathway regulates macrophage polarization.  Nat Comm. 2013;4:2834.

Kagan JC, Horng T.  NLRP3 inflammasome activation:  CD36 serves double duty.  Nat Immunol. 2013 Aug;14(8):772-4.

Covarrubias A, Byles V, Horng T.  ROS sets the stage for macrophage differentiation.  Cell Res. 2013 Aug;23(8):984-5.

Murakami T, Ockinger J, Yu J, Byles V, Mccoll A, Hofer A and Horng T.  A critical role for calcium mobilization in activation of the NLRP3 inflammasome.  PNAS. 2012 Jul 10;109(28):11282-7.

Horng T and Hotamisligil. Linking the inflammasome to obesity-related disease. Nature Medicine. 2011, Feb;17(2)164-5.

Medzhitov R and Horng T.  Transcriptional control of the inflammatory response.  Nature Reviews Immunology 2009 Oct;9(10):692-703.  PMID:19859064.

Hargreaves DC, Horng T*, Medzhitov R*. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell. 2009 Jul 10;138(1):129-45. PMC2828818. *co-corresponding authors