Publications

Publications

Horng, T. mTOR trains heightened macrophage responses. Trends in Immunology, 2015, Jan;36(1):1-2.

Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman H, and Horng, T. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. PNAS, 2014, Oct 28;111(43):15514-9.

Covarrubias AJ and Horng T. IL-6 strikes a balance during metabolic inflammation. Cell Metabolism, 2014 Jun 3;19(6)898-9.

Horng, T. Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome. Trends in Immunology, epub Mar 16, 2014.

Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T.  The TSC-mTOR pathway regulates macrophage polarization.  Nat Comm. 2013;4:2834.

Kagan JC, Horng T.  NLRP3 inflammasome activation:  CD36 serves double duty.  Nat Immunol. 2013 Aug;14(8):772-4.

Covarrubias A, Byles V, Horng T.  ROS sets the stage for macrophage differentiation.  Cell Res. 2013 Aug;23(8):984-5.

Murakami T, Ockinger J, Yu J, Byles V, Mccoll A, Hofer A and Horng T.  A critical role for calcium mobilization in activation of the NLRP3 inflammasome.  PNAS. 2012 Jul 10;109(28):11282-7.

Horng T and Hotamisligil. Linking the inflammasome to obesity-related disease. Nature Medicine. 2011, Feb;17(2)164-5.

Medzhitov R and Horng T.  Transcriptional control of the inflammatory response.  Nature Reviews Immunology 2009 Oct;9(10):692-703.  PMID:19859064.

Hargreaves DC, Horng T*, Medzhitov R*. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell. 2009 Jul 10;138(1):129-45. PMC2828818. *co-corresponding authors