Publications

Publications

Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T.  The TSC-mTOR pathway regulates macrophage polarization.  Nat Comm. 2013;4:2834.

Kagan JC, Horng T.  NLRP3 inflammasome activation:  CD36 serves double duty.  Nat Immunol. 2013 Aug;14(8):772-4.

Covarrubias A, Byles V, Horng T.  ROS sets the stage for macrophage differentiation.  Cell Res. 2013 Aug;23(8):984-5.

Murakami T, Ockinger J, Yu J, Byles V, Mccoll A, Hofer A and Horng T.  A critical role for calcium mobilization in activation of the NLRP3 inflammasome.  PNAS. 2012 Jul 10;109(28):11282-7.

Horng T and Hotamisligil GS. Linking the inflammasome to obesity-related diseases.  Nature Medicine 2011.  Feb;17(2):164-5.  PMID:21297609.

Medzhitov R and Horng T.  Transcriptional control of the inflammatory response.  Nature Reviews Immunology 2009 Oct;9(10):692-703.  PMID:19859064.

Hargreaves DC, Horng T*, Medzhitov R*. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell. 2009 Jul 10;138(1):129-45. PMC2828818. *co-corresponding authors

Horng, T, Oberdoerffer, S and Rao, A.  Gene regulation and signal transduction in the immune system. Genome Biology 2008, Jul 10; 9(7):315.  PMID: 18644102, PMC2530879 

Kagan J, Su T, Horng T, Chow A, and Medzhitov R.  Tram functions as a sorting adaptor that couples TLR4 internalization with IFN-β induction.  Nature Immunology 2008, Apr.,9(4):361-8.  PMID: 18297073

Horng T*, Bezbradica J, and Medzhitov R*.  NKG2D signaling is coupled with the interleukin 15 receptor signaling pathway.  Nature Immunology 2007, Dec 8(12):1345-1352. PMID: 17952078  *co-corresponding authors

Schwab SR, Shugart JA, Horng T, Malarkannan S, and Shastri N.  Unanticipated antigens: translation initiation at CUG with leucine. PLos biol 2004,Nov;2(11):e366.  PMID: 15510226, PMC524250

Horng T, Barton GM, Flavell RA, and Medzhitov, R.  The adaptor molecule TIRAP provides signaling specificity for Toll-like receptors. Nature 2002, Nov 21;420(6913):329-33. PMID: 12447442

Lauvau G, Vijh S, Kong P, Horng T, Kerksiek K, Serbina N, Tuma RA, and Pamer EG.  Priming of memory but not effector CD8 T cells by a killed bacterial vaccine.  Science 2001,Nov 23;294(5547):1735-9.

Horng T and Medzhitov R. Drosophila MyD88 is an adapter in the Toll signaling pathway.  PNAS2001, Oct 23;98(22):12654-8.

Horng T, Barton GM and Medzhitov R.  TIRAP:  an adapter molecule in the Toll signalingpathway.  Nat. Immuol 2001, Sep;2(9):835-41.

Xu Y, Tao X, Shen B, HorngT, Medzhitov R, Manley JL and Tong L.  Nature 2000, Nov 2;408(6808):111-5. 

Malarkannan S, Horng T, Eden P, Gonzalez F, Shih P, Brouwenstijn N, Klinge H, Christianson G, Roopenian D and Shastri N. Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens.  Immunity 2000, Sep;13(3):333-44.

Malarkannan S, Horng T, Shih PP, Schwab S and Shastri N.  Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism.  Immunity1999, Jun;10(6):681-90.

Malarkannan S, Shih PP, Eden PA, Horng T, Zuberi AR, Christianson G, Roopenian D and Shastri N.  The molecular and functional characterization of a dominant minor H antigen, H60. J Immunol 1998, Oct 1;161(7):3501-9.