Selected Publications

Hwang, A. B., Ryu, E., Artan, M., Chang, H., Kabir, M. H., Nam, H., Lee, D., Yang, J., Kim, S., Mair, W. B., Lee, C., Lee, S. S., and Lee, S. 2014. Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C. elegans. PNAS. In Press.

Burkewitz, K., Zhang, Y., and Mair, W. B. (2014). AMPK at the nexus of energetics and aging. Cell Metabolism. Jul 1;20(1):10-25.

Heintz, C. and Mair, W. (2014). You Are What You Host: Microbiome Modulation of the Aging Process. Cell 156. 408-411

Mair, W.  (2013). Tipping the energy balance toward longevity. Cell Metabolism. 17(1):5-6.

Mair, W., Morantte, I., Rodrigues, A. P. C., Manning, G., Montminy, M., Shaw, R. J., and Dillin, A. (2011). Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature 470, 404–U179.

Mair W, Steffen KK, Dillin A. (2011). SIP-ing the elixir of youth. Cell. 16;146(6):859-60.

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., Asara, J.M., Fitzpatrick, J., Dillin, A., Viollet, B., Kundru, M., Hansen, M., Shaw, R. J. (2011). Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331, 456–461.

Mair, W., McLeod, C. J., Wang, L., and Jones, D. L. (2010). Dietary restriction enhances germline stem cell maintenance. Aging Cell 9, 916–918.

Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U, and Hetzer, M.W. (2010). Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes. Cell. 140 (3) 372-383.

Mair, W., Panowski, S., Shaw, R.J. and Dillin, A. (2009). Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans. PLoS ONE 4:e4535.

Mair, W., and Dillin, A. (2008). Aging and survival: the genetics of life span extension by dietary restriction. Annu. Rev. Biochem. 77, 727–754.

Magwere, T., Goodhall, S., Skepper, J., Mair, W., Brand, M.D. and Partridge,L. (2006) The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila. J Gerontol A Biol Sci. 61:36-47.

Mair, W., Piper, M. D. W., and Partridge, L. (2005). Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol 3, e223.

Piper, M.D., Mair, W. and Partridge, L. (2005) Counting the calories: the role of specific nutrients in extension of lifespan by food restriction. J Gerontol A Biol Sci. 60:549-555.

Partridge, L., Piper, M.D. and Mair, W. (2005). Dietary Restriction in Drosophila. Mech Ageing Dev. 126:938-950.

Partridge, L., Pletcher, S.D. and Mair, W. (2005) Dietary restriction, mortality trajectories, risk and damage. Mech Ageing Dev. 126:35-41.

Mair, W., Sgro, C.M., Johnson, A.P., Chapman, T. and Partridge, L. (2004). Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogensis or ovarian activity. Exp Geron 39:1011-1019.

Hulbert, A.J., Clancy, D.J., Mair, W., Braeckman, B.P., Gems, D. and Partridge, L. (2004) Metabolic rate is not reduced by dietary restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exp Geron 39:1137-1143.

Mair, W., Goymer, P., Pletcher, S. D., and Partridge, L. (2003). Demography of dietary restriction and death in Drosophila. Science 301, 1731–1733.