An HIV Prevention Program for Mochudi, Botswana

Country/Countries:
,

Principal Investigator:
Myron Essex, Mary Woodard Lasker Professor of Health Sciences

Department:
Immunology+Infectious Diseases Prime

Sponsors:
NIH/NIAID

Dates of Research:
September 29, 2009 — August 31, 2012

Description:

The Specific Aims of this project are (1) to characterize the HIV epidemic in Mochudi by estimating incidence and prevalence of HIV and of behavioral risk factors at 3 time points over a 2½-year period; (2) to determine uptakes of voluntary counseling and testing, condom use, acceptability of partner notification with contact tracing, and male circumcision; (3) to identify transmission associations with genome signature tracing to evaluate associations between transmissions and high VL; (4) to estimate the rate of acceptance of HAART offered upon detection to HIV-infected individuals with acute infection and/or VL 100,000 who do not otherwise qualify for treatment based on national guidelines (AIDS-defining illness or CD4 < 250), and to assess adherence to drug schedules and rates of baseline and new drug resistance; and (5) to develop model-based projections and assessments of the potential for epidemic control, and to use these models to evaluate the cost effectiveness of combinations of preventive interventions.

Website: http://www.hsph.harvard.edu/bhp/