Bioengineering Analysis of Muscle Mechanics and Metabolism


Principal Investigator:
Srboljub Mijailovich

Molecular and Integrative Physiological Sciences Program

Dates of Research:
September 1, 2003 — April 30, 2009


Using the methods of engineering analysis, this study will develop a computational platform that incorporates current knowledge of molecular structure, biochemical energetics, and contraction kinetics to describe muscle contraction. The goal of this research project is to develop a comprehensive model that can be used to (1) generate new mechanistic hypotheses concerning the functions of the contractile proteins myosin and actin and (2) quantitatively evaluate the roles of accessory and regulatory proteins in contraction. Once developed, this model will be a powerful analytical and predictive tool in studies of muscle contraction.