Childhood Dioxin Exposure and Energy Homeostasis Dysregulation


Principal Investigator:
Jane Burns, Research Associate

EH-Environmental+Occupational Medicine+Epi

Dates of Research:
August 1, 2009 — July 31, 2012


This project aims to incorporate measurements of metabolic abnormalities into an ongoing longitudinal cohort study evaluating the associates of serum dioxins and PCBS with growth and pubertal development in 499 boys in Chapaevsk, Russia. The study is in its fourth year in which the boys, enrolled at 8 to 9 years old, and is evaluated yearly and will be followed through puberty to adulthood. At enrollment, the boys provided blood samples for dioxin and PCB analyses, in order to measure peri-pubertal exposure. The boys receive annual physical examinations that include anthropomorphic measurements, and detailed family medical, dietary, and residential information is collected. This project is to extend the original aims of the this study to evaluate whether higher peri-pubertal serum dioxins and PCB levels are associated dysregulation of energy homeostasis, with a specific focus on glucose, lipid, and adipocyte metabolism, and adiposity. The proposal’s prospective design will permit us to evaluate whether exposure to elevated dioxins and PCBS during the peri-pubertal period is associated with subsequent glucose dysregulation, altered fat and adipokine metabolism, and increased adiposity.